{"id":6170,"date":"2024-07-18T13:22:03","date_gmt":"2024-07-18T17:22:03","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=6170"},"modified":"2024-07-29T12:39:57","modified_gmt":"2024-07-29T16:39:57","slug":"dougald-monroe-phd-has-a-review-article-published-in-blood","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/07\/dougald-monroe-phd-has-a-review-article-published-in-blood\/","title":{"rendered":"Dougald Monroe, PhD review article published in Blood"},"content":{"rendered":"<p>&#8220;Blood coagulation factor IX: structural insights impacting hemophilia B therapy&#8221; was recently accepted for publication in the journal Blood. The work is a collaboration between BRC Center member Dougald Monroe and Leiden University Medical Center investigators Rianne Elaine van Diest and Mettine H A Bos. This review focuses on analyzing the structure of factor IX with respect to molecular mechanisms that are at the basis of factor IX function. The manuscript also examines how changes in factor IX structure can lead to enhanced activity that might provide for better therapeutics. This review is part of a series that also looks at structure\/function of factor VIII and von Willebrand factor.\u00a0 \u00a0<strong><a href=\"https:\/\/ashpublications.org\/blood\/article-abstract\/doi\/10.1182\/blood.2023023276\/517006\/Blood-coagulation-factor-IX-structural-insights?redirectedFrom=fulltext\">Read full text here<\/a><\/strong><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2024\/07\/Monroe_paper_visual_abstract.pdf\">Monroe_paper_visual_abstract<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6194 alignleft\" src=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2024\/07\/Monroe_paper_visual_abstract-1-300x225.jpg\" alt=\"\" width=\"315\" height=\"236\" srcset=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2024\/07\/Monroe_paper_visual_abstract-1-300x225.jpg 300w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2024\/07\/Monroe_paper_visual_abstract-1-768x576.jpg 768w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2024\/07\/Monroe_paper_visual_abstract-1-280x210.jpg 280w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2024\/07\/Monroe_paper_visual_abstract-1-600x450.jpg 600w, https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2024\/07\/Monroe_paper_visual_abstract-1.jpg 960w\" sizes=\"auto, (max-width: 315px) 100vw, 315px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Blood coagulation factor IX: structural insights impacting hemophilia B therapy&#8221; was recently accepted for publication in the journal Blood. The work is a collaboration between BRC Center member Dougald Monroe and Leiden University Medical Center investigators Rianne Elaine van Diest and Mettine H A Bos. This review focuses on analyzing the structure of factor IX &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/07\/dougald-monroe-phd-has-a-review-article-published-in-blood\/\" aria-label=\"Read more about Dougald Monroe, PhD review article published in Blood\">Read more<\/a><\/p>\n","protected":false},"author":116232,"featured_media":5149,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-6170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dougald Monroe, PhD review article published in Blood | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/07\/dougald-monroe-phd-has-a-review-article-published-in-blood\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dougald Monroe, PhD review article published in Blood | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"&#8220;Blood coagulation factor IX: structural insights impacting hemophilia B therapy&#8221; was recently accepted for publication in the journal Blood. 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This review focuses on analyzing the structure of factor IX &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2024\/07\/dougald-monroe-phd-has-a-review-article-published-in-blood\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-18T17:22:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-29T16:39:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/01\/2022-09-30_Monroe_2_headshot_small.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1093\" \/>\n\t<meta property=\"og:image:height\" content=\"1063\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"mavakian\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" 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