{"id":6579,"date":"2025-03-21T15:24:50","date_gmt":"2025-03-21T19:24:50","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=6579"},"modified":"2025-06-05T15:49:49","modified_gmt":"2025-06-05T19:49:49","slug":"three-brc-labs-collaborate-to-study-sickle-cell-trait","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/03\/three-brc-labs-collaborate-to-study-sickle-cell-trait\/","title":{"rendered":"Three BRC Labs Collaborate to Study Sickle Cell Trait"},"content":{"rendered":"<p>Three BRC Labs Collaborate to study Sickle Cell Trait:<\/p>\n<p>In a recently published study, three BRC groups (Key, Pawlinski and Kasztan labs) performed an in-depth study of venous thrombosis and chronic kidney disease in heterozygous Townes sickle mice as a model of human sickle cell trait. The authors suggest that the mouse model can be used to further understand the mechanisms of these complications. Notably, it is estimated that about 300 million people worldwide, who are mostly asymptomatic, carry the sickle gene, such that even modest risk of these complications may have significant implications for public health.<\/p>\n<p>The publication may be viewed at the following link:<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2473952925001582\">Addressing the pathophysiology of venous thrombosis and chronic kidney disease in sickle cell trait using a mouse model &#8211; ScienceDirect<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Three BRC Labs Collaborate to study Sickle Cell Trait: In a recently published study, three BRC groups (Key, Pawlinski and Kasztan labs) performed an in-depth study of venous thrombosis and chronic kidney disease in heterozygous Townes sickle mice as a model of human sickle cell trait. The authors suggest that the mouse model can be &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/03\/three-brc-labs-collaborate-to-study-sickle-cell-trait\/\" aria-label=\"Read more about Three BRC Labs Collaborate to Study Sickle Cell Trait\">Read more<\/a><\/p>\n","protected":false},"author":117184,"featured_media":3317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-6579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Three BRC Labs Collaborate to Study Sickle Cell Trait | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/03\/three-brc-labs-collaborate-to-study-sickle-cell-trait\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Three BRC Labs Collaborate to Study Sickle Cell Trait | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"Three BRC Labs Collaborate to study Sickle Cell Trait: In a recently published study, three BRC groups (Key, Pawlinski and Kasztan labs) performed an in-depth study of venous thrombosis and chronic kidney disease in heterozygous Townes sickle mice as a model of human sickle cell trait. The authors suggest that the mouse model can be &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/03\/three-brc-labs-collaborate-to-study-sickle-cell-trait\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2025-03-21T19:24:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-05T19:49:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2020\/07\/Key-UNC-photo-731x1024.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"731\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"martimic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta 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