{"id":6741,"date":"2025-08-07T16:03:48","date_gmt":"2025-08-07T20:03:48","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=6741"},"modified":"2025-08-12T10:28:22","modified_gmt":"2025-08-12T14:28:22","slug":"matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/","title":{"rendered":"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI."},"content":{"rendered":"<p class=\"x_MsoNormal\"><span data-olk-copy-source=\"MessageBody\">Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI.<\/span><\/p>\n<p class=\"x_MsoNormal\">Authors:\u00a0<b>Matthew S. Karafin<\/b>, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang,\u00a0Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A.\u00a0Reisz, Nigel S. Key, Joshua J. Field, Jane A. Little, Steven L. Spitanik, Angelo D\u2019Alessandro.<\/p>\n<p class=\"x_MsoNormal\">Citation:\u00a0<b>Karafin MS<\/b>, Grier AL, Fasano RM, Ilich A, Wichlan D, Chang A, James SM, Butler HE, Kolupaev O, Caughey MC, Stephenson DJ, Reisz JA, Key NS, Field JJ, Little JA, Spitalnik SL, D&#8217;Alessandro A. Blood-storage duration affects hematological and metabolic profiles in patients with sickle cell disease receiving transfusions. J Clin Invest. 2025 Jul 3:e192920. doi: 10.1172\/JCI192920. Epub ahead of print. PMID: 40608427.<\/p>\n<p class=\"x_MsoNormal\"><b>Summary of findings:<\/b><\/p>\n<p class=\"x_MsoNormal\">Patients with sickle cell disease (SCD) frequently receive red blood cell (RBC) units stored near the end of their permissible storage life. To evaluate whether storage duration influences recipient\u00a0metabolism, clinical chemistry and hematological parameters, we conducted a prospective, randomized, blinded trial comparing transfusions of RBC units stored for \u226410 days versus \u226530 days.\u00a0\u00a0Chronically transfused adults with SCD (N=24) received three consecutive outpatient transfusions with randomized-age RBCs, and blood samples from units and recipients were analyzed by\u00a0metabolomics and clinical chemistry. Transfusion of short-stored units resulted in significantly higher circulating levels of 2,3-bisphosphoglycerate, an essential regulator of oxygen unloading, up to two\u00a0weeks post-transfusion. Conversely, transfusions of long-stored RBCs were associated with lower hemoglobin and RBC increments, higher iron and transferrin saturation, pro-inflammatory cytokines\u00a0and metabolites, oxidative stress and markers of renal dysfunction. Plasma and RBC metabolomic profiles revealed time- and storage-age-dependent alterations, particularly affecting glycolysis,\u00a0purine, and sphingolipid metabolism. Transfusion of long-stored RBCs consistently worsened laboratory surrogates of oxygen delivery and RBC efficacy, and increased the circulating levels of\u00a0immunomodulatory metabolites and pro-inflammatory cytokines. These findings highlight metabolic and hematologic advantages associated with transfusing fresher RBCs in adults with SCD.\u00a0 The additional relationships between storage duration and key clinical outcomes from this same clinical trial has just been accepted for publication in\u00a0<b>Blood RCI<\/b>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI. Authors:\u00a0Matthew S. Karafin, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang,\u00a0Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A.\u00a0Reisz, Nigel S. Key, Joshua J. Field, Jane A. Little, Steven L. Spitanik, &hellip; <a href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\" aria-label=\"Read more about Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI.\">Read more<\/a><\/p>\n","protected":false},"author":117184,"featured_media":3954,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-6741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI. | UNC Blood Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI. | UNC Blood Research Center\" \/>\n<meta property=\"og:description\" content=\"Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI. Authors:\u00a0Matthew S. Karafin, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang,\u00a0Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A.\u00a0Reisz, Nigel S. Key, Joshua J. Field, Jane A. Little, Steven L. Spitanik, &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Blood Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2025-08-07T20:03:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-12T14:28:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1050\" \/>\n\t<meta property=\"og:image:height\" content=\"1500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"martimic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"martimic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\"},\"author\":{\"name\":\"martimic\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/34aa2e69041ab767074ddc2afa2e672d\"},\"headline\":\"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI.\",\"datePublished\":\"2025-08-07T20:03:48+00:00\",\"dateModified\":\"2025-08-12T14:28:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\"},\"wordCount\":357,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\",\"name\":\"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI. | UNC Blood Research Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg\",\"datePublished\":\"2025-08-07T20:03:48+00:00\",\"dateModified\":\"2025-08-12T14:28:22+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/34aa2e69041ab767074ddc2afa2e672d\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg\",\"width\":1050,\"height\":1500,\"caption\":\"photo of matthew karafin, smiling in a suit\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/\",\"name\":\"UNC Blood Research Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/34aa2e69041ab767074ddc2afa2e672d\",\"name\":\"martimic\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/cf0386d60ba440da0e2453decd8535f25cd6d42b52d95ccae93a7d89f7097176?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/cf0386d60ba440da0e2453decd8535f25cd6d42b52d95ccae93a7d89f7097176?s=96&d=mm&r=g\",\"caption\":\"martimic\"},\"url\":\"https:\/\/www.med.unc.edu\/bloodresearchcenter\/author\/martimic\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI. | UNC Blood Research Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/","og_locale":"en_US","og_type":"article","og_title":"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI. | UNC Blood Research Center","og_description":"Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI. Authors:\u00a0Matthew S. Karafin, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang,\u00a0Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A.\u00a0Reisz, Nigel S. Key, Joshua J. Field, Jane A. Little, Steven L. Spitanik, &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/","og_site_name":"UNC Blood Research Center","article_published_time":"2025-08-07T20:03:48+00:00","article_modified_time":"2025-08-12T14:28:22+00:00","og_image":[{"width":1050,"height":1500,"url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg","type":"image\/jpeg"}],"author":"martimic","twitter_card":"summary_large_image","twitter_misc":{"Written by":"martimic","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/"},"author":{"name":"martimic","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/34aa2e69041ab767074ddc2afa2e672d"},"headline":"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI.","datePublished":"2025-08-07T20:03:48+00:00","dateModified":"2025-08-12T14:28:22+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/"},"wordCount":357,"image":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/","name":"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI. | UNC Blood Research Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg","datePublished":"2025-08-07T20:03:48+00:00","dateModified":"2025-08-12T14:28:22+00:00","author":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/34aa2e69041ab767074ddc2afa2e672d"},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#primaryimage","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg","contentUrl":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg","width":1050,"height":1500,"caption":"photo of matthew karafin, smiling in a suit"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/08\/matthew-karafin-md-ms-published-the-initial-results-of-his-prospective-randomized-clinical-trial-in-jci\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/"},{"@type":"ListItem","position":2,"name":"Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI."}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#website","url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/","name":"UNC Blood Research Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/34aa2e69041ab767074ddc2afa2e672d","name":"martimic","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/cf0386d60ba440da0e2453decd8535f25cd6d42b52d95ccae93a7d89f7097176?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/cf0386d60ba440da0e2453decd8535f25cd6d42b52d95ccae93a7d89f7097176?s=96&d=mm&r=g","caption":"martimic"},"url":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/author\/martimic\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color-210x300.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color-768x1097.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color-717x1024.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-content\/uploads\/sites\/1089\/2021\/07\/51523-005-matthew_karafin_large_color-150x150.jpg","featured_image_alt":"photo of matthew karafin, smiling in a suit","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/posts\/6741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/users\/117184"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/comments?post=6741"}],"version-history":[{"count":4,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/posts\/6741\/revisions"}],"predecessor-version":[{"id":6747,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/posts\/6741\/revisions\/6747"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/media\/3954"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/media?parent=6741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/categories?post=6741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/wp-json\/wp\/v2\/tags?post=6741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}