{"id":6797,"date":"2025-09-11T11:35:18","date_gmt":"2025-09-11T15:35:18","guid":{"rendered":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/?p=6797"},"modified":"2025-11-13T14:23:08","modified_gmt":"2025-11-13T19:23:08","slug":"dougald-monroe-phd-allen-ma-phd-and-maureane-hoffman-phd-md-published-in-blood-vessels-thrombosis-hemostasis","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bloodresearchcenter\/2025\/09\/dougald-monroe-phd-allen-ma-phd-and-maureane-hoffman-phd-md-published-in-blood-vessels-thrombosis-hemostasis\/","title":{"rendered":"Dougald Monroe, PhD, Allen Ma, and Maureane Hoffman, PhD MD, published in Blood Vessels, Thrombosis, & Hemostasis."},"content":{"rendered":"

Dr Monroe and colleagues published a study on the role of plasma inhibitors in regulating thrombin levels.<\/p>\n

Dougald Monroe, professor in the UNC Division of Hematology, and colleagues Allen Ma and Maureane Hoffman published their study on the contribution of four plasma inhibitors in regulating thrombin generation. The work was published in Blood Vessels, Thrombosis, & Hemostasis.<\/p>\n

Study findings:
\nMultiple inhibitors, including antithrombin (AT), heparin cofactor II, \u03b12-macroglobulin, and \u03b11-antitrypsin, contribute to thrombin inhibition in plasma. As AT is lowered, the roles of the other inhibitors become more significant. These inhibitors can completely inhibit thrombin even in the absence of AT. These findings may be relevant for novel therapies that reduce AT levels to rebalance hemostasis in people with hemophilia A or B.<\/p>\n

Paper is available:
\nhttps:\/\/doi.org\/10.1016\/j.bvth.2025.100088<\/a><\/p>\n

 <\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Dr Monroe and colleagues published a study on the role of plasma inhibitors in regulating thrombin levels. Dougald Monroe, professor in the UNC Division of Hematology, and colleagues Allen Ma and Maureane Hoffman published their study on the contribution of four plasma inhibitors in regulating thrombin generation. 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