{"id":6530,"date":"2019-08-29T09:22:39","date_gmt":"2019-08-29T13:22:39","guid":{"rendered":"https:\/\/www.med.unc.edu\/bric\/?page_id=6530"},"modified":"2019-08-29T10:20:17","modified_gmt":"2019-08-29T14:20:17","slug":"analysis-service","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bric\/camri\/analysis-service\/","title":{"rendered":"Analysis Service"},"content":{"rendered":"

fMRI-Standard Preprocessing<\/h2>\n
\n
\n

1<\/span> Slice timing problem correction<\/p>\n

\"\"<\/p>\n<\/div>\n

\n

2<\/span> Head motion correction<\/p>\n

\"\"<\/p>\n<\/div>\n<\/div>\n

\n
\n

3<\/span> Skull stripping<\/p>\n

\"\"<\/p>\n<\/div>\n

\n

4<\/span> Coregistration<\/p>\n

\"\"<\/p>\n<\/div>\n<\/div>\n

 <\/p>\n

\n
\n

5<\/span> Spatial Normalization<\/p>\n

\"\"<\/p>\n<\/div>\n

\n

 <\/p>\n<\/div>\n<\/div>\n

\n

fMRI-Evoked<\/h2>\n

Overview of Pipeline<\/h3>\n
\n
\n1<\/span><\/div>\n
\n

Estimate the task-driven BOLD response model<\/p>\n<\/div>\n<\/div>\n

\n
\n2<\/span><\/div>\n
\n

Create subject evoked response map using General Linear Model (GLM) analysis<\/p>\n<\/div>\n<\/div>\n

\n
\n3<\/span><\/div>\n
\n

Group-level statistics<\/p>\n<\/div>\n<\/div>\n

Sample Figures<\/h3>\n

Group evoked response map of optogenetic stimulation on Striatum<\/p>\n

\"\"<\/p>\n

\n

fMRI-Resting State<\/h2>\n
\n
\n1<\/span><\/div>\n
\n

Nuisance signal regression (6 degrees of motion parameter)<\/p>\n<\/div>\n<\/div>\n

\n
\n2<\/span><\/div>\n
\n

Frequency filtering (Typical range of band-pass filter: 0.01 ~ 0.1Hz)<\/p>\n<\/div>\n<\/div>\n

\n
\n3<\/span><\/div>\n
\n

Calculate resting state parameters: ALFF, ReHo, Seed-based connectivity, etc.<\/p>\n<\/div>\n<\/div>\n

\n
\n4<\/span><\/div>\n
\n

Group-level statistics<\/p>\n<\/div>\n<\/div>\n

Sample Figures<\/h3>\n

Seed-based voxel-wise connectivity map from single subject (Wistar rat P80)<\/p>\n

\n
\n

Default mode network<\/strong><\/p>\n

\"\"<\/p>\n

Seed location: CG<\/p>\n<\/div>\n

\n

Primary Somatosensory<\/strong><\/p>\n

\"\"<\/p>\n

Seed location: S1<\/p>\n<\/div>\n<\/div>\n

\n

DTI<\/h2>\n

Overview of Pipeline<\/h3>\n
\n
\n1<\/span><\/div>\n
\n\"\"<\/p>\n

Rigid Registration<\/h4>\n

Individual cases are aligned to an external template atlas and the DTI metrics are computed from the raw DWI image<\/p>\n<\/div>\n<\/div>\n

\n
\n
\n2<\/span><\/div>\n
\n\"\"<\/p>\n

Skull Stripping<\/h4>\n

All non-brain tissue is removed from the image<\/p>\n<\/div>\n<\/div>\n

\n
\n
\n3<\/span><\/div>\n
\n

Population Average Creation<\/h4>\n

The registered images are averaged together to create an image that is representative of the population of data.<\/p>\n<\/div>\n<\/div>\n

\n
\n
\n4<\/span><\/div>\n
\n

\"\"Population Average Segmentation<\/h4>\n

The segmentation from the external template atlas is applied to the population atlas<\/p>\n<\/div>\n<\/div>\n

\n
\n
\n5<\/span><\/div>\n
\n

Segmentation Propagation<\/h4>\n

The segmentation from the population average image is propagated, or warped back to the individual subjects.<\/p>\n<\/div>\n<\/div>\n

\n
\n
\n6<\/span><\/div>\n
\n

Region Based Statistics<\/h4>\n

Both volume and diffusion based-metrics (FA, MD, AD, RD) can be gathered from the indvidual cases\u2019 warped segmentation.<\/div>\n<\/div>\n

\n

Sample Figures<\/h3>\n

Average Image of Colored FA<\/p>\n

\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n<\/div>\n

 <\/p>\n

Average Image of MD, AD, RD<\/p>\n

\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n<\/div>\n

 <\/p>\n

3D Images with ROIs<\/p>\n

\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n<\/div>\n

 <\/p>\n

Average Image with 20 ROIs \/ Bar graphs and correlation plots<\/p>\n

\n
\n\"\"<\/div>\n
\n\"\"<\/div>\n
\n<\/div>\n
\n<\/div>\n<\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

fMRI-Standard Preprocessing   fMRI-Evoked Overview of Pipeline Sample Figures Group evoked response map of optogenetic stimulation on Striatum fMRI-Resting State Sample Figures Seed-based voxel-wise connectivity map from single subject (Wistar rat P80) DTI Overview of Pipeline Sample Figures Average Image of Colored FA   Average Image of MD, AD, RD   3D Images with ROIs … Read more<\/a><\/p>\n","protected":false},"author":3206,"featured_media":0,"parent":3444,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-6530","page","type-page","status-publish","hentry","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"\nAnalysis Service - Biomedical Research Imaging Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bric\/camri\/analysis-service\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analysis Service - Biomedical Research Imaging Center\" \/>\n<meta property=\"og:description\" content=\"fMRI-Standard Preprocessing   fMRI-Evoked Overview of Pipeline Sample Figures Group evoked response map of optogenetic stimulation on Striatum fMRI-Resting State Sample Figures Seed-based voxel-wise connectivity map from single subject (Wistar rat P80) DTI Overview of Pipeline Sample Figures Average Image of Colored FA   Average Image of MD, AD, RD   3D Images with ROIs … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bric\/camri\/analysis-service\/\" \/>\n<meta property=\"og:site_name\" content=\"Biomedical Research Imaging Center\" \/>\n<meta property=\"article:modified_time\" content=\"2019-08-29T14:20:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bric\/wp-content\/uploads\/sites\/843\/2019\/08\/fmri_standard01.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/camri\/analysis-service\/\",\"url\":\"https:\/\/www.med.unc.edu\/bric\/camri\/analysis-service\/\",\"name\":\"Analysis Service - 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