{"id":8130,"date":"2025-08-27T10:20:49","date_gmt":"2025-08-27T14:20:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/bric\/?page_id=8130"},"modified":"2025-08-27T14:53:27","modified_gmt":"2025-08-27T18:53:27","slug":"pet","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bric\/preclinical-molecular-imaging\/pmi-equipment\/pet\/","title":{"rendered":"PET Imaging"},"content":{"rendered":"
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Instruments<\/strong><\/h3>\n
\n\n\n\n\n
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Super Argus 4R PET\/CT<\/em><\/h4>\n

The SuperArgus-4R system (Sedecal, Inc) offers multimodal PET\/CT imaging in small animals including rodents, rabbits, ferrets, etc.\u00a0 It incorporates a dual layer detector with LYSO and GSO crystals to provide PET imaging with high sensitivity and high resolution.\u00a0 The integrated CT unit provides high resolution CT images for anatomical registration and cobined diagnosis.<\/p>\n

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Main Imaging Features<\/p>\n<\/div>\n

\n
    \n
  • High Sensitivity: 11% at Center Point<\/li>\n
  • High Resolution: 1mm at Center Point using 3D-OSEM reconstruction<\/li>\n
  • Large PET field of view (FOV):\u00a0 150mm bore size; 100mm axial FOV<\/li>\n
  • Fast CT acquisition: ~2 min CT acquisition depending on the protocol<\/li>\n<\/ul>\n<\/div>\n<\/td>\n


\n\"image2\"<\/span><\/td>\n<\/tr>\n
\n

SuperArgus Compact PET<\/em><\/h4>\n

The SuperArgus Compact PET system is a portable PET system with a small footprint.\u00a0 It can conduct PET imaging on one mouse for each imaging session.\u00a0 This PET system is featured with high sensitivity (>15%), which allows imaging with a very low dose of radioactivity.\u00a0 The compact size enables the system to be placed on a mobile table for any imaging needs.<\/td>\n

\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/header>\n<\/div>\n
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\n<\/div>\n
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Sample Images and Study Examples<\/strong><\/h3>\n

To see sample images from our optical imaging systems please follow this\u00a0link<\/a>.<\/p>\n

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PET Imaging Probes<\/strong><\/h3>\n


\n<\/strong>Pet probes can be obtained either fro commercial vendors or from the BRIC Cyclotron and Radiochemistry facility.\u00a0 The following are some common PET probes available upon request:<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Probe<\/strong><\/td>\nTarget molecule <\/strong><\/td>\nFunctionality\/Pathology<\/strong><\/td>\n<\/tr>\n
18<\/sup>F-FDG<\/td>\nGlucose<\/td>\nTumor\/inflammation<\/td>\n<\/tr>\n
18<\/sup>F -FLT<\/td>\nThymidine kinase<\/td>\nCell proliferation<\/td>\n<\/tr>\n
18<\/sup>F -FMISO<\/td>\nNitroimidazole<\/td>\nTumor hypoxia<\/td>\n<\/tr>\n
18<\/sup>F -FES<\/td>\nEstrogen<\/td>\nBreast cancer<\/td>\n<\/tr>\n
18<\/sup>F-Fallypride<\/td>\nD2\/D3 Dopamine receptor<\/td>\nDopamine receptor imaging<\/td>\n<\/tr>\n
18<\/sup>F-FDOPA<\/td>\nL-DOPA<\/td>\nDopamine synthesis<\/td>\n<\/tr>\n
18<\/sup>F -T807<\/td>\nTau protein<\/td>\nAlzheimer<\/td>\n<\/tr>\n
18<\/sup>F-PBR111<\/td>\nTSPO protein<\/td>\nNeuroinflammation<\/td>\n<\/tr>\n
11<\/sup>C-S1PR1<\/td>\nSphingosine-1-phosphate receptor<\/td>\nNeuroinflammation<\/td>\n<\/tr>\n
11<\/sup>C-Choline<\/td>\nPhospholipid synthesis<\/td>\nCancer (prostate, brain)<\/td>\n<\/tr>\n
11<\/sup>C-Acetate<\/td>\nAcetate<\/td>\nLipid metabolism<\/td>\n<\/tr>\n
11<\/sup>C -Raclopride<\/td>\nD2 dopamine receptor<\/td>\nDopamine receptor imaging<\/td>\n<\/tr>\n
11<\/sup>C-PIB<\/td>\nb-Amyloid<\/td>\nAlzheimer<\/td>\n<\/tr>\n
11<\/sup>C -CB1R<\/td>\nCannabinoid Receptor<\/td>\nNeuropsychiatric disorders<\/td>\n<\/tr>\n
11<\/sup>C -UCB-J<\/td>\nSynaptic vesicle glycoprotein 2A<\/td>\nSynaptic density imaging<\/td>\n<\/tr>\n
11<\/sup>C -AMT<\/td>\nIndoleamine 2,3-dioxygenase-1 (IOD1)<\/td>\nImmune response; Serotonin system<\/td>\n<\/tr>\n
64<\/sup>Cu<\/td>\nLabeling for various compound<\/td>\n<\/td>\n<\/tr>\n
89<\/sup>Zr<\/td>\nLabeling for various compound<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n<\/div>\n

\n

Study Initiation, Training and Scheduling<\/strong><\/p>\n

\n

The majority of PET\/CT imaging studies are conducted with PMI staff support.\u00a0 To initate a PET\/CT imaging study, please send an email to\u00a0<\/span>bricpmi@med.unc.edu<\/a> to schedule a meeting and register your project by following the study initiation link<\/a>.\u00a0 You can also see our <\/span>study initiation page<\/a> for more details.
\n<\/span><\/p>\n

\n

Cost<\/strong><\/h3>\n

The current internal rate for PET\/CT imaging and staff support is $160\/hr and $53\/hr.\u00a0 Imaging time is highly dependent upon the study protocol so please contact the PMI for budget information.\u00a0 You can also see our rates at this link<\/a>.<\/p>\n<\/div>\n

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 <\/p>\n

\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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