{"id":7682,"date":"2023-05-23T08:56:33","date_gmt":"2023-05-23T12:56:33","guid":{"rendered":"https:\/\/www.med.unc.edu\/bric\/?p=7682"},"modified":"2023-05-31T09:09:50","modified_gmt":"2023-05-31T13:09:50","slug":"breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/","title":{"rendered":"Breaking Through Bacterial Barriers in Chronic Treatment-Resistant Wounds"},"content":{"rendered":"
\"The
The cover art illustrates ultrasound-mediated drug delivery into a biofilm-infected wound. Illustration by Ella Marushchenko.<\/figcaption><\/figure>\n

Researchers at the\u00a0UNC School of Medicine<\/a>\u00a0and the\u00a0UNC-NC State Joint Department of Biomedical Engineering, <\/a>have developed a new method that combines palmitoleic acid, gentamicin, and non-invasive ultrasound to help improve drug delivery in chronic wounds that have been infected with\u00a0S. aureus<\/em>.<\/p>\n

Using their new strategy, researchers including BRIC faculty member Dr. Paul Dayton, and Dr. Sarah Rowe-Conlon of the Department of Microbiology and Immunology, were able to reduce the challenging MRSA infection in the wounds of diabetic mice by 94%. They were able to completely sterilize the wounds in several of the mice, and the rest had significantly reduced bacterial burden. Their results were published<\/a>\u00a0in\u00a0Cell Chemical Biology<\/em>.<\/p>\n

https:\/\/news.unchealthcare.org\/2023\/05\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds?utm_source=Vital+Signs&utm_campaign=Vital+Signs+5-25-23&utm_medium=email<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at the\u00a0UNC School of Medicine\u00a0and the\u00a0UNC-NC State Joint Department of Biomedical Engineering, have developed a new method that combines palmitoleic acid, gentamicin, and non-invasive ultrasound to help improve drug delivery in chronic wounds that have been infected with\u00a0S. aureus. Using their new strategy, researchers including BRIC faculty member Dr. Paul Dayton, and Dr. Sarah … Read more<\/a><\/p>\n","protected":false},"author":53245,"featured_media":7684,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[46,2,61,54],"tags":[65,53,31],"class_list":["post-7682","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bric","category-news","category-research","category-small-animal-imaging","tag-news","tag-publications","tag-research","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"\nBreaking Through Bacterial Barriers in Chronic Treatment-Resistant Wounds - Biomedical Research Imaging Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Breaking Through Bacterial Barriers in Chronic Treatment-Resistant Wounds - Biomedical Research Imaging Center\" \/>\n<meta property=\"og:description\" content=\"Researchers at the\u00a0UNC School of Medicine\u00a0and the\u00a0UNC-NC State Joint Department of Biomedical Engineering, have developed a new method that combines palmitoleic acid, gentamicin, and non-invasive ultrasound to help improve drug delivery in chronic wounds that have been infected with\u00a0S. aureus. Using their new strategy, researchers including BRIC faculty member Dr. Paul Dayton, and Dr. Sarah … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/\" \/>\n<meta property=\"og:site_name\" content=\"Biomedical Research Imaging Center\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-23T12:56:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-31T13:09:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bric\/wp-content\/uploads\/sites\/843\/2023\/05\/Cell_Chemical_Biology_Cover_Illustration-MAY23.png\" \/>\n\t<meta property=\"og:image:width\" content=\"751\" \/>\n\t<meta property=\"og:image:height\" content=\"697\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Emily Page\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Emily Page\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/\"},\"author\":{\"name\":\"Emily Page\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/#\/schema\/person\/77188a11e4610ca55a320dcbb7a4e019\"},\"headline\":\"Breaking Through Bacterial Barriers in Chronic Treatment-Resistant Wounds\",\"datePublished\":\"2023-05-23T12:56:33+00:00\",\"dateModified\":\"2023-05-31T13:09:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/\"},\"wordCount\":161,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/bric\/wp-content\/uploads\/sites\/843\/2023\/05\/Cell_Chemical_Biology_Cover_Illustration-MAY23.png\",\"keywords\":[\"News\",\"Publications\",\"Research\"],\"articleSection\":[\"Biomedical Research Imaging Center\",\"News\",\"Research\",\"Small Animal Imaging\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/\",\"url\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/\",\"name\":\"Breaking Through Bacterial Barriers in Chronic Treatment-Resistant Wounds - Biomedical Research Imaging Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/bric\/wp-content\/uploads\/sites\/843\/2023\/05\/Cell_Chemical_Biology_Cover_Illustration-MAY23.png\",\"datePublished\":\"2023-05-23T12:56:33+00:00\",\"dateModified\":\"2023-05-31T13:09:50+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/#\/schema\/person\/77188a11e4610ca55a320dcbb7a4e019\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/bric\/wp-content\/uploads\/sites\/843\/2023\/05\/Cell_Chemical_Biology_Cover_Illustration-MAY23.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/bric\/wp-content\/uploads\/sites\/843\/2023\/05\/Cell_Chemical_Biology_Cover_Illustration-MAY23.png\",\"width\":751,\"height\":697,\"caption\":\"The cover art illustrates ultrasound-mediated drug delivery into a biofilm-infected wound. 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