{"id":7688,"date":"2023-01-31T15:00:08","date_gmt":"2023-01-31T20:00:08","guid":{"rendered":"https:\/\/www.med.unc.edu\/bric\/?p=7688"},"modified":"2023-05-31T15:11:15","modified_gmt":"2023-05-31T19:11:15","slug":"researchers-unveil-new-collection-of-human-brain-atlases-that-charts-the-early-developing-brain-in-fine-detail","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/bric\/researchers-unveil-new-collection-of-human-brain-atlases-that-charts-the-early-developing-brain-in-fine-detail\/","title":{"rendered":"Researchers Unveil New Collection of Human Brain Atlases that Charts the Early Developing Brain in Fine Detail"},"content":{"rendered":"

\"\"Human brain atlases can be used by medical professionals to track normative trends over time and pinpoint crucial aspects of early brain development.<\/p>\n

With these atlases, they are able to see what typical structural and functional development looks like, making it easier for them to spot the symptoms of abnormal development, such as attention-deficit\/hyperactivity disorder (ADHD), dyslexia, and cerebral palsy.<\/p>\n

Pew-Thian Yap, PhD, professor in the UNC Department of Radiology, and colleagues in the department and the Biomedical Research Imaging Center (BRIC) have created a new collection of month-by-month infant brain atlas (IBA) that capture fine details of the early developing brain across both space and time.<\/p>\n

In this work, published in the journal Nature Methods, the scientists created a set of month-specific surface-volume longitudinal brain atlases of infants from 2 weeks to 2 years of age. Sahar Ahmad, PhD, research instructor of radiology, was lead author on the paper.<\/p>\n

\u201cBrain atlases are key to understanding neurodevelopment through the lenses of cellular composition, neural pathways, and functional organization,\u201d Yap said. \u201cThe human brain atlases created by our team depict the early development phase of postnatal neurodevelopment. Our atlases will be a resource valuable to brain scientists in unraveling key normative and aberrant traits of, arguably, the most important phase of human brain development.\u201d<\/p>\n

Throughout the first two years of life, the human brain undergoes a whole range of cellular processes that drive the rapid growth of the infant brain. It is during this period that the brain changes structurally and reorganizes its neural circuits. When development goes awry, it can have detrimental effects on the quality of life, including heightened risk for autism, schizophrenia, and ADHD.<\/p>\n

\"Infant
Surface-volume atlases from 2 weeks to 24 months. \u00a9 2023, Ahmad et al., CCBY 4.0<\/figcaption><\/figure>\n

By using the IBA, researchers are able to capture changes in brain structure, cortical geometry, and tissue contrast.<\/p>\n

The atlases also revealed that cortices in the temporal, parietal, and prefrontal regions of the brain are thicker than the primary visual and sensorimotor cortices. This is consistent with the finding that the higher-order functions of the infant brain \u2013 such as attention, working memory, inhibition, and problem-solving \u2013 mature more slowly than the areas of the brain that are responsible for the visual, motor, and sensory functions.<\/p>\n

Overall, the surface-volume consistent IBA accurately captures the infant growth trajectories and does so with rich anatomical details. These atlases recorded the monthly changes in the normally developing brains\u2019 size, shape, and cortical geometry as well as their tissue contrast, volume, and microstructural characteristics from 2 weeks to 2 years of age.<\/p>\n

\u201cWe hope that these atlases will become a common coordinate framework to facilitate the discovery of new insights into developmental processes underpinning child cognition and social behavior,\u201d Yap said.<\/p>\n

This research was funded by the the National Institute of Biomedical Imaging and Bioengineering under grant R01EB008374 and the National Institute of Mental Health under grant R01MH125479.<\/p>\n

https:\/\/www.nature.com\/articles\/s41592-022-01703-z<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Human brain atlases can be used by medical professionals to track normative trends over time and pinpoint crucial aspects of early brain development. With these atlases, they are able to see what typical structural and functional development looks like, making it easier for them to spot the symptoms of abnormal development, such as attention-deficit\/hyperactivity disorder … Read more<\/a><\/p>\n","protected":false},"author":53245,"featured_media":7689,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[46,43,2],"tags":[38,53,31],"class_list":["post-7688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bric","category-bric-imageanalysis","category-news","tag-bric-imageanalysis","tag-publications","tag-research","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"\nResearchers Unveil New Collection of Human Brain Atlases that Charts the Early Developing Brain in Fine Detail - Biomedical Research Imaging Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bric\/researchers-unveil-new-collection-of-human-brain-atlases-that-charts-the-early-developing-brain-in-fine-detail\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers Unveil New Collection of Human Brain Atlases that Charts the Early Developing Brain in Fine Detail - Biomedical Research Imaging Center\" \/>\n<meta property=\"og:description\" content=\"Human brain atlases can be used by medical professionals to track normative trends over time and pinpoint crucial aspects of early brain development. 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