{"id":3949,"date":"2017-07-13T15:15:00","date_gmt":"2017-07-13T19:15:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/"},"modified":"2018-08-23T16:24:18","modified_gmt":"2018-08-23T20:24:18","slug":"copy_of_bric-seminar-series-november-2017","status":"publish","type":"tribe_events","link":"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/","title":{"rendered":"BRIC Seminar Series October 2017 &#8211; Nicolas Tsapis, PhD"},"content":{"rendered":"<div>\n<h3>Nicolas Tsapis, Ph.D.<\/h3>\n<p>Institute Galien Paris-Sud, CRNS, Universite Paris-Sud, Universite Paris-Saclay<\/p>\n<\/p>\n<p align=\"center\" style=\"text-align: left; \"><b><i>Capsules of Perfluorocarbons as Theranostic Agents<\/i><\/b><\/p>\n<p><b>Abstract<\/b><\/p>\n<p>The need to detect cancer at its early stages, as well as, to deliver chemotherapy to targeted site motivates many researchers to build theranostic platforms which combine diagnostic and therapy. Among imaging modalities, ultrasonography and MRI are widely available, non invasive and complement each other. Both techniques often require the use of contrast agents.<\/p>\n<p>We have developed nanocapsules of perfluorocarbons as dual contrast agent for both imaging modalities. The soft, amorphous polymer shell provides echogenicity, while the high-density perfluorinated liquid core allows detection by <sup>19<\/sup> F MRI. We have used mainly a shell of poly(lactide-co-glycolide) (PLGA) since this polymer is biodegradable, biocompatible and can be loaded with drugs. These capsules were shown to be efficient <i>in vitro<\/i> as contrast agents for both <sup>19<\/sup> F MRI and ultrasonography<sup>1<\/sup>. In addition, for <i>in vivo<\/i> applications a poly(ethyleneglycol) (PEG) coating promotes stability and prolonged circulation. Being stealth, nanocapsule can accumulate passively into implanted tumors by the EPR effect. We will present nanocapsule formulation and characterization, and will show promising in vivo results obtained for both ultrasonography and <sup>19<\/sup> F MRI<sup>2<\/sup>. The accumulation by EPR effect favors the efficacy of a chemotherapeutic agent co-encapsulated, proving the feasibility of the theranostic approach. The different parameters one can play with to modulate the detection of these contrast agents will be presented. The limitations of these nanoparticles and the strategies to overcome them will be reviewed.<\/p>\n<p align=\"center\" style=\"text-align: left; \"><b><i><br \/><\/i><\/b><\/p>\n<p align=\"center\"><b><i><br \/><\/i><\/b><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nicolas Tsapis, Ph.D. Institute Galien Paris-Sud, CRNS, Universite Paris-Sud, Universite Paris-Saclay Capsules of Perfluorocarbons as Theranostic Agents Abstract The need to detect cancer at its early stages, as well as, to deliver chemotherapy to targeted site motivates many researchers to build theranostic platforms which combine diagnostic and therapy. Among imaging modalities, ultrasonography and MRI are &hellip; <a href=\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/\" aria-label=\"Read more about BRIC Seminar Series October 2017 &#8211; Nicolas Tsapis, PhD\">Read more<\/a><\/p>\n","protected":false},"author":53245,"featured_media":0,"template":"","meta":{"_acf_changed":false,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","_links_to":"","_links_to_target":""},"tags":[17],"tribe_events_cat":[],"class_list":["post-3949","tribe_events","type-tribe_events","status-publish","hentry","tag-biomedical-research-imaging-center","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BRIC Seminar Series October 2017 - Nicolas Tsapis, PhD - Biomedical Research Imaging Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BRIC Seminar Series October 2017 - Nicolas Tsapis, PhD - Biomedical Research Imaging Center\" \/>\n<meta property=\"og:description\" content=\"Nicolas Tsapis, Ph.D. Institute Galien Paris-Sud, CRNS, Universite Paris-Sud, Universite Paris-Saclay Capsules of Perfluorocarbons as Theranostic Agents Abstract The need to detect cancer at its early stages, as well as, to deliver chemotherapy to targeted site motivates many researchers to build theranostic platforms which combine diagnostic and therapy. Among imaging modalities, ultrasonography and MRI are &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/\" \/>\n<meta property=\"og:site_name\" content=\"Biomedical Research Imaging Center\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-23T20:24:18+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/\",\"url\":\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/\",\"name\":\"BRIC Seminar Series October 2017 - Nicolas Tsapis, PhD - Biomedical Research Imaging Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/#website\"},\"datePublished\":\"2017-07-13T19:15:00+00:00\",\"dateModified\":\"2018-08-23T20:24:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/bric\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Events\",\"item\":\"https:\/\/www.med.unc.edu\/bric\/events\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"BRIC Seminar Series October 2017 &#8211; Nicolas Tsapis, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/bric\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/bric\/\",\"name\":\"Biomedical Research Imaging Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/bric\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"BRIC Seminar Series October 2017 - Nicolas Tsapis, PhD - Biomedical Research Imaging Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/bric\/event\/copy_of_bric-seminar-series-november-2017\/","og_locale":"en_US","og_type":"article","og_title":"BRIC Seminar Series October 2017 - Nicolas Tsapis, PhD - Biomedical Research Imaging Center","og_description":"Nicolas Tsapis, Ph.D. Institute Galien Paris-Sud, CRNS, Universite Paris-Sud, Universite Paris-Saclay Capsules of Perfluorocarbons as Theranostic Agents Abstract The need to detect cancer at its early stages, as well as, to deliver chemotherapy to targeted site motivates many researchers to build theranostic platforms which combine diagnostic and therapy. 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