Keywords: Duration recommendations are provided as a general guideline for therapy (IV or PO) with a goal of minimizing unintended consequences to the patient (e.g., precipitating C. difficile colitis, development of resistant pathogens, organ dysfunction). Patient-specific factors should influence duration decisions and transition to oral therapy.
Keywords: The guide serves as an antibiotic selection and dosing reference for clinicians who are providing care to pediatric patients with infectious diseases caused by particular Gram-negative pathogens (e.g., Pseudomonas aeruginosa, AmpC-producing Enterobacterales). These topics were purposefully identified due to the variety of antibiotic dosing recommendations available for pediatric patients; however, depending on the organism or site of infection, specific dosing regimens are required to optimize the pharmacokinetic and pharmacodynamic (PKPD) parameters of the bug-drug-site interaction.
Keywords: Restricted anti-infective drugs may be approved by the ID consult services or by the Carolina Antimicrobial Stewardship Program (CASP). Restricted anti-infectives initiated by the ID medicine service (MDK) do not require approval.
The Advisory Committee on Immunization Practices (ACIP) provides advice and guidance to the Director of the US Centers for Disease Control and Prevention regarding use of vaccines and related agents for control of vaccine-preventable diseases in the civilian population of the United States.