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X-ORIGINAL-URL:https://www.med.unc.edu/cellbiophysio
X-WR-CALDESC:Events for Department of Cell Biology and Physiology
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DTSTART:20231105T060000
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241014T123000
DTEND;TZID=America/New_York:20241014T133000
DTSTAMP:20260409T184942
CREATED:20241011T190542Z
LAST-MODIFIED:20241011T190542Z
UID:10000423-1728909000-1728912600@www.med.unc.edu
SUMMARY:Monday - FUSION: Sam Ryken & Frankie Marchan
DESCRIPTION:Sam Ryken \n\n\n\n\n(Gupton lab)\n\n  \n\n\n \n\n\nFrankie Marchan \n\n\n\n\n(Bear lab)\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-sam-ryken-frankie-marchan/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241021T123000
DTEND;TZID=America/New_York:20241021T133000
DTSTAMP:20260409T184942
CREATED:20241011T182649Z
LAST-MODIFIED:20241016T160325Z
UID:10000422-1729513800-1729517400@www.med.unc.edu
SUMMARY:Monday - FUSION: Amber Gomez & Kayla Mason
DESCRIPTION:Amber Gomez (Milner and Baldwin labs) \n\n\n\n\n\nUnderstanding the molecular regulators of CD8 T cell exhaustion\n\n\n\n  \n\n\n \n\n\nKayla Mason (Conlon lab) \n\n\n\n\n\nDdx3x is required in female cardiomyocytes of mice for cardiac development\nIdentifying DDX3X translationally dependent cardiomyocyte specific mRNA targets underlying sex differential congenital heart disease  \n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-amber-gomez-kayla-mason/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241028T123000
DTEND;TZID=America/New_York:20241028T133000
DTSTAMP:20260409T184942
CREATED:20241011T191116Z
LAST-MODIFIED:20241022T190830Z
UID:10000424-1730118600-1730122200@www.med.unc.edu
SUMMARY:Monday - FUSION: Garrett Sessions & Anca Frasineanu
DESCRIPTION:Garrett Sessions (Purvis & Diekman labs) \n\n\n\n\n\nAggregate analysis of cellular senescence fails to identify the effect of key subpopulations\nSenescence induction is heterogeneous over time\, making time point selection critical for designing future experiments\n\n\n\n  \n\n\n \n\n\nAnca Frasineanu (Gupton lab) \n\n\n\n\n\nTRIM9 deletion decreases mitochondrial translation and increases nuclear speckle proteins in the PSD proteome of 6-month-old PS19 mice\nCultured cortical neurons from TRIM9 KO embryos undergo slight changes in mitochondrial morphology\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-garrett-sessions-anca-frasineanu/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241104T123000
DTEND;TZID=America/New_York:20241104T133000
DTSTAMP:20260409T184942
CREATED:20241016T203827Z
LAST-MODIFIED:20241104T182944Z
UID:10000425-1730723400-1730727000@www.med.unc.edu
SUMMARY:Monday - FUSION: Jocelyn Alvarado & Max Hockenberry
DESCRIPTION:Jocelyn Alvarado (Campbell lab) \n\n\n\n\n\nCharacterizing the effect of increasing levels of metavinculin on force transmission in MEFs at the general cellular level and at local focal adhesions\n\n\n\n  \n\n\n \n\n\nMax Hockenberry (Bear and Legant labs) \n\n\n\n\n\nDeveloping a method to quantitatively measure the traction forces produced by cells migrating in any arbitrary 3D geometry\nApplying this methodology to understand how cells physically propel their nucleus through tight confinements\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-jocelyn-alvarado-max-hockenberry/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241209T123000
DTEND;TZID=America/New_York:20241209T133000
DTSTAMP:20260409T184942
CREATED:20241030T182213Z
LAST-MODIFIED:20250102T163825Z
UID:10000426-1733747400-1733751000@www.med.unc.edu
SUMMARY:Monday - FUSION: Matt Zimmerman & Nicole Hondrogiannis
DESCRIPTION:Matt Zimmerman (Miller lab) \n\n\n\n\n\nFRb inhibits macrophage survival and suppresses anti-tumor functions in vitro\nFRb ablation decreases tumor growth in preliminary experiments\n\n\n\n  \n\n\n \n\n\nNicole Hondrogiannis (Deshmukh lab) \n\n\n\n\n\nNeurons are long-lived post mitotic cells\nExploring if the apoptotic pathway in neurons becomes activated in response to sublethal DNA damage
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-matt-zimmerman-nicole-hondrogiannis/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250113T123000
DTEND;TZID=America/New_York:20250113T133000
DTSTAMP:20260409T184942
CREATED:20250102T160455Z
LAST-MODIFIED:20250108T172256Z
UID:10000431-1736771400-1736775000@www.med.unc.edu
SUMMARY:Monday – FUSION: Juliet King & Alex Powers
DESCRIPTION:Juliet King (Williams lab) \n\n\n\n\n  \n\n\n  \n\n\n \n\n\nAlex Powers (Cohen lab) \n\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-juliet-king-alex-powers/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250127T123000
DTEND;TZID=America/New_York:20250127T133000
DTSTAMP:20260409T184942
CREATED:20250102T163237Z
LAST-MODIFIED:20250123T194301Z
UID:10000432-1737981000-1737984600@www.med.unc.edu
SUMMARY:Monday – FUSION: Ian McCabe & Mark Hazelbaker
DESCRIPTION:Ian McCabe (Yeh lab) \n\n\n\n\n\nIdentifying two clinically relevant populations of CAFs in PDAC: tumor promoting (proCAF) and tumor restrictive (restCAF)\nThese CAF subtypes are distributed spatially and may play distinct functional roles\n\n\n\n\n\n \n\n\nMark Hazelbaker (Bear lab) \n\n\n\n\n\nThe Arp2/3 complex is required for the turnover of clathrin plaques\nACK regulates the recruitment of the Arp2/3 complex via tyrosine phosphorylation
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-ian-mccabe-mark-hazelbaker/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250203T123000
DTEND;TZID=America/New_York:20250203T133000
DTSTAMP:20260409T184942
CREATED:20250102T164603Z
LAST-MODIFIED:20250131T165051Z
UID:10000433-1738585800-1738589400@www.med.unc.edu
SUMMARY:Monday – FUSION: David Rocco & Andrew Kennedy
DESCRIPTION:David Rocco (Bergmeier lab) \n\n\n\n\n\nElucidating a novel pathway for platelet activation\nUnderstanding how this pathway contributes to platelet adhesion under arterial shear stress\n\n\n\n  \n\n\n \n\n\nAndrew Kennedy (Thaxton lab) \n\n\n\n\n\nER sheet dynamics are distended in T cells in solid cancers\nBalancing ER sheets and tubules may protect T cells from disturbed ER dynamics in solid tumors
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-david-rocco-andrew-kennedy/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250217T123000
DTEND;TZID=America/New_York:20250217T133000
DTSTAMP:20260409T184942
CREATED:20250106T185735Z
LAST-MODIFIED:20250217T143358Z
UID:10000434-1739795400-1739799000@www.med.unc.edu
SUMMARY:Monday – FUSION: Kimberly Lukasik & Emily Bulik-Sullivan
DESCRIPTION:Kimberly Lukasik (Gupton lab) \n\n\n\nTRIM9 modulates focal adhesion dynamics to regulate cell motility in melanoma\n\n\n\n  \n\n\n  \n\n\n \n\n\nEmily Bulik-Sullivan (Randell lab) \n\n\n\nElucidating the mechanism of ENaC activity reduction by CC-90009\nThis mechanism\, and CC-90009’s capacity to promote ribosomal readthrough of PTC-CFTR variants is of therapeutic interest for cystic fibrosis\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-kimberly-lukasik-emily-bulik-sullivan/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250303T123000
DTEND;TZID=America/New_York:20250303T133000
DTSTAMP:20260409T184942
CREATED:20250106T214648Z
LAST-MODIFIED:20250226T191340Z
UID:10000441-1741005000-1741008600@www.med.unc.edu
SUMMARY:Monday - FUSION: Gabby Bais & Sherry Hsu
DESCRIPTION:Gabby Bais (Giudice lab) \n\n\n\nFXR1 may regulate the translation of many cardiomyocyte-specific proteins\nExpression of muscle-specific splice isoforms of FXR1 may impact the contractility of the adult heart\n\n\n\n  \n\n\n  \n\n\n \n\n\nSherry Hsu (Cohen lab) \n\n\n\nTubulin acetylation and polyglutamylation increase early in neuronal differentiation\, exhibit distinct distributions\, and are important for maintaining neuronal morphology\nTubulin acetylation regulates lysosome morphology and its contacts with the endoplasmic reticulum and mitochondria\, highlighting its role in lysosomal function during neuronal differentiation\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-gabby-bais-sherry-hsu/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250324T123000
DTEND;TZID=America/New_York:20250324T133000
DTSTAMP:20260409T184942
CREATED:20250106T215012Z
LAST-MODIFIED:20250327T145529Z
UID:10000442-1742819400-1742823000@www.med.unc.edu
SUMMARY:Monday - FUSION: Henry Uchenna\, Meghan Anderman\, & Ashlyn Laidman
DESCRIPTION:Henry Uchenna (Maddox lab) \n\n\n\nCapping Protein depletion accelerates furrowing and cytokinesis\, likely due to increased F-actin in the contractile ring\nIt also disrupts spindle dynamics\, potentially through effects on the dynein-dynactin complex\n\n\n\n  \n\n\n  \n\n\n \n\n\nMeghan Anderman (McCauley lab) \n\n\n\nUsing human intestinal organoids to model gastrointestinal (GI) pathophysiology in cystic fibrosis\nAssessing the general role of CFTR in GI development and function\n\n\n\n  \n\n\n  \n\n\n \n\n\nAshlyn Laidman (Bressan lab) \n\n\n\nTesting different hypotheses to figure out what cues are directing the stereotyped collective cell migration of the epicardium across the myocardium during development\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-henry-uchenna-meghan-anderman-ashlyn-laidman/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250331T123000
DTEND;TZID=America/New_York:20250331T133000
DTSTAMP:20260409T184942
CREATED:20250106T192312Z
LAST-MODIFIED:20250327T145653Z
UID:10000437-1743424200-1743427800@www.med.unc.edu
SUMMARY:Monday - FUSION: Leo Bondel\, Katie Holmes\, & Jake Roetcisoender
DESCRIPTION:Leo Bondel (Zylka lab) \n\n\n\nOur goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons\, which allow for installation of a Poly(A) signal with cytosine base editors\nThese edits have the potential to restore UBE3A expression\, making this an attractive therapeutic strategy for Angelman Syndrome\n\n\n\n  \n\n\n  \n\n\n \n\n\nKatie Holmes (Baldwin lab) \n\n\n\nWhite matter astrocytes maintain key astrocytic features like tiling and endfeet but their morphological characteristics are quantifiably distinct\nWhite matter astrocytes take longer to mature than other astrocytes\n\n\n\n  \n\n\n  \n\n\n \n\n\nJake Roetcisoender (O’Brien lab) \n\n\n\nVascular smooth muscle cells impact nerve development in the kidney\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/14558/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250421T123000
DTEND;TZID=America/New_York:20250421T133000
DTSTAMP:20260409T184942
CREATED:20250106T193034Z
LAST-MODIFIED:20250415T183138Z
UID:10000438-1745238600-1745242200@www.med.unc.edu
SUMMARY:Monday - FUSION: Jack Bennett\, Lauren Griffith\, & Shenice Harrison
DESCRIPTION:Jack Bennett (Cook lab) \n\n\n\nIntracellular pH can be manipulated by inhibiting ion transporters\, and these changes can be measured by flow cytometry\npH manipulations may alter cell cycle progression\, arresting cells in the G1 phase of the cell cycle\n\n\n\n  \n\n\n  \n\n\n \n\n\nLauren Griffith (Williams lab) \n\n\n\nExplore how integrin-β1 and its adaptor protein Talin loss-of function affects oriented cell divisions and telophase correction in fixed tissue and live imaging\nExplore how integrin-β1 and its adaptor protein Talin loss-of function impacts basal cell delamination\n\n\n\n  \n\n\n  \n\n\n \n\n\nShenice Harrison (Edwards lab) \n\n\n\nImpaired myristoylation disrupts sarcomere organization and reduces sarcomere length in embryonic cardiomyocytes\nOptimizing a metabolic labeling strategy to identify the myristoylated cardiac proteins required for proper sarcomere assembly\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-katie-holmes-lauren-griffith-shenice-harrison/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250428T123000
DTEND;TZID=America/New_York:20250428T133000
DTSTAMP:20260409T184942
CREATED:20250106T210736Z
LAST-MODIFIED:20250424T133653Z
UID:10000439-1745843400-1745847000@www.med.unc.edu
SUMMARY:Monday – FUSION: Michelle LaBella & Mady Chlebowski
DESCRIPTION:Michelle LaBella (Yeh lab) \n\n\n\nTNIK is required to restrain tumor invasion in PDAC\n\nClear difference in mechanism when compared to colorectal/lung cancer\n\n\nTNIK is a newly identified regulator of PLAT\, tPA expression and ECM modulation through fibrin degradation\nNew mechanism for PDAC invasion and metastasis\, may be what restrains classical tumors\n\n\n\n  \n\n\n  \n\n\n \n\n\nMady Chlebowski (Shiau & Chen labs) \n\n\n\nDistinct neuroimmune and other cell-cell interactions may serve as early signatures of neurodegeneration prior to overt morphological cell death\nThis holds promise for early detection or intervention of neurodegenerative diseases\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-michelle-labella-mady-chlebowski/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250505T123000
DTEND;TZID=America/New_York:20250505T133000
DTSTAMP:20260409T184942
CREATED:20250106T211516Z
LAST-MODIFIED:20250501T165046Z
UID:10000440-1746448200-1746451800@www.med.unc.edu
SUMMARY:Monday: FUSION - Anna Beeson & Vickie Williams
DESCRIPTION:Anna Beeson (Caron lab) \n\n\n\nAdrenomedullin robustly increases both mouse fertility and pinopode formation\nAlternative model systems are allowing us to interrogate pinopode formation in novel ways\n\n\n\n  \n\n\n  \n\n\n \n\n\nVickie Williams (Cohen lab) \n\n\n\nDimerization fluorescent proteins are a useful tool that can show increased ER-LD contacts under conditions of lipid droplet biogenesis\nDimerization-dependent fluorescent proteins can modulate LD size when used to induce ER-LD contact sites\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-anna-beeson-vickie-williams/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250818T123000
DTEND;TZID=America/New_York:20250818T133000
DTSTAMP:20260409T184942
CREATED:20250813T204353Z
LAST-MODIFIED:20250813T204353Z
UID:10000448-1755520200-1755523800@www.med.unc.edu
SUMMARY:Monday - FUSION:Keith Breau & Pierre N’Guetta
DESCRIPTION:Keith Breau (Magness and Elston labs) \n\n\n\nUsing a reaction-diffusion model to simulate planar cell polarity in an epithelial cell layer\nDemonstrating a role for planar cell polarity in regulating intestinal epithelial migration\n\n\n\n  \n\n\n  \n\n\n \n\n\nPierre N’Guetta (O’Brien lab) \n\n\n\nTotal renal denervation in mice leads to a decrease in number of nephron developed\nDenervated kidneys exhibit impaired balance between self-renewal and differentiation of progenitor populations\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusionkeith-breau-pierre-nguetta/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250825T123000
DTEND;TZID=America/New_York:20250825T133000
DTSTAMP:20260409T184942
CREATED:20250822T194510Z
LAST-MODIFIED:20250822T194618Z
UID:10000449-1756125000-1756128600@www.med.unc.edu
SUMMARY:Monday - FUSION: Max Hockenberry & Christina So
DESCRIPTION:Max Hockenberry (Bear and Legant labs) \n\n\n\nWe have developed an imaging based approach to directly visualize the motion of single molecules of actin and the arp2/3 complex in living cells.\nWe have used this approach and preliminary data to assess how molecules of these proteins get to the front of the cell for incorporation in polymerizing actin networks at the leading edge.\n\n\n\n  \n\n\n  \n\n\n \n\n\nChristina So (Neher lab) \n\n\n\nANGPTL3 and ANGPTL8 are both lipoprotein inhibitors that form a complex in the cell prior to secretion. When not in complex\, ANGPTL8 gets trafficked to lysosomes\, and it is unknown how ANGPTL3 diverts ANGPTL8 from lysosomes.\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-max-hockenberry-christina-so/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
END:VCALENDAR