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X-ORIGINAL-URL:https://www.med.unc.edu/cellbiophysio
X-WR-CALDESC:Events for Department of Cell Biology and Physiology
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250324T123000
DTEND;TZID=America/New_York:20250324T133000
DTSTAMP:20260603T083906
CREATED:20250106T215012Z
LAST-MODIFIED:20250327T145529Z
UID:10000442-1742819400-1742823000@www.med.unc.edu
SUMMARY:Monday - FUSION: Henry Uchenna\, Meghan Anderman\, & Ashlyn Laidman
DESCRIPTION:Henry Uchenna (Maddox lab) \n\n\n\nCapping Protein depletion accelerates furrowing and cytokinesis\, likely due to increased F-actin in the contractile ring\nIt also disrupts spindle dynamics\, potentially through effects on the dynein-dynactin complex\n\n\n\n  \n\n\n  \n\n\n \n\n\nMeghan Anderman (McCauley lab) \n\n\n\nUsing human intestinal organoids to model gastrointestinal (GI) pathophysiology in cystic fibrosis\nAssessing the general role of CFTR in GI development and function\n\n\n\n  \n\n\n  \n\n\n \n\n\nAshlyn Laidman (Bressan lab) \n\n\n\nTesting different hypotheses to figure out what cues are directing the stereotyped collective cell migration of the epicardium across the myocardium during development\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-henry-uchenna-meghan-anderman-ashlyn-laidman/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250331T123000
DTEND;TZID=America/New_York:20250331T133000
DTSTAMP:20260603T083906
CREATED:20250106T192312Z
LAST-MODIFIED:20250327T145653Z
UID:10000437-1743424200-1743427800@www.med.unc.edu
SUMMARY:Monday - FUSION: Leo Bondel\, Katie Holmes\, & Jake Roetcisoender
DESCRIPTION:Leo Bondel (Zylka lab) \n\n\n\nOur goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons\, which allow for installation of a Poly(A) signal with cytosine base editors\nThese edits have the potential to restore UBE3A expression\, making this an attractive therapeutic strategy for Angelman Syndrome\n\n\n\n  \n\n\n  \n\n\n \n\n\nKatie Holmes (Baldwin lab) \n\n\n\nWhite matter astrocytes maintain key astrocytic features like tiling and endfeet but their morphological characteristics are quantifiably distinct\nWhite matter astrocytes take longer to mature than other astrocytes\n\n\n\n  \n\n\n  \n\n\n \n\n\nJake Roetcisoender (O’Brien lab) \n\n\n\nVascular smooth muscle cells impact nerve development in the kidney\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/14558/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250421T123000
DTEND;TZID=America/New_York:20250421T133000
DTSTAMP:20260603T083906
CREATED:20250106T193034Z
LAST-MODIFIED:20250415T183138Z
UID:10000438-1745238600-1745242200@www.med.unc.edu
SUMMARY:Monday - FUSION: Jack Bennett\, Lauren Griffith\, & Shenice Harrison
DESCRIPTION:Jack Bennett (Cook lab) \n\n\n\nIntracellular pH can be manipulated by inhibiting ion transporters\, and these changes can be measured by flow cytometry\npH manipulations may alter cell cycle progression\, arresting cells in the G1 phase of the cell cycle\n\n\n\n  \n\n\n  \n\n\n \n\n\nLauren Griffith (Williams lab) \n\n\n\nExplore how integrin-β1 and its adaptor protein Talin loss-of function affects oriented cell divisions and telophase correction in fixed tissue and live imaging\nExplore how integrin-β1 and its adaptor protein Talin loss-of function impacts basal cell delamination\n\n\n\n  \n\n\n  \n\n\n \n\n\nShenice Harrison (Edwards lab) \n\n\n\nImpaired myristoylation disrupts sarcomere organization and reduces sarcomere length in embryonic cardiomyocytes\nOptimizing a metabolic labeling strategy to identify the myristoylated cardiac proteins required for proper sarcomere assembly\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-katie-holmes-lauren-griffith-shenice-harrison/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250428T123000
DTEND;TZID=America/New_York:20250428T133000
DTSTAMP:20260603T083906
CREATED:20250106T210736Z
LAST-MODIFIED:20250424T133653Z
UID:10000439-1745843400-1745847000@www.med.unc.edu
SUMMARY:Monday – FUSION: Michelle LaBella & Mady Chlebowski
DESCRIPTION:Michelle LaBella (Yeh lab) \n\n\n\nTNIK is required to restrain tumor invasion in PDAC\n\nClear difference in mechanism when compared to colorectal/lung cancer\n\n\nTNIK is a newly identified regulator of PLAT\, tPA expression and ECM modulation through fibrin degradation\nNew mechanism for PDAC invasion and metastasis\, may be what restrains classical tumors\n\n\n\n  \n\n\n  \n\n\n \n\n\nMady Chlebowski (Shiau & Chen labs) \n\n\n\nDistinct neuroimmune and other cell-cell interactions may serve as early signatures of neurodegeneration prior to overt morphological cell death\nThis holds promise for early detection or intervention of neurodegenerative diseases\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-michelle-labella-mady-chlebowski/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250505T123000
DTEND;TZID=America/New_York:20250505T133000
DTSTAMP:20260603T083906
CREATED:20250106T211516Z
LAST-MODIFIED:20250501T165046Z
UID:10000440-1746448200-1746451800@www.med.unc.edu
SUMMARY:Monday: FUSION - Anna Beeson & Vickie Williams
DESCRIPTION:Anna Beeson (Caron lab) \n\n\n\nAdrenomedullin robustly increases both mouse fertility and pinopode formation\nAlternative model systems are allowing us to interrogate pinopode formation in novel ways\n\n\n\n  \n\n\n  \n\n\n \n\n\nVickie Williams (Cohen lab) \n\n\n\nDimerization fluorescent proteins are a useful tool that can show increased ER-LD contacts under conditions of lipid droplet biogenesis\nDimerization-dependent fluorescent proteins can modulate LD size when used to induce ER-LD contact sites\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-anna-beeson-vickie-williams/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250818T123000
DTEND;TZID=America/New_York:20250818T133000
DTSTAMP:20260603T083906
CREATED:20250813T204353Z
LAST-MODIFIED:20250813T204353Z
UID:10000448-1755520200-1755523800@www.med.unc.edu
SUMMARY:Monday - FUSION:Keith Breau & Pierre N’Guetta
DESCRIPTION:Keith Breau (Magness and Elston labs) \n\n\n\nUsing a reaction-diffusion model to simulate planar cell polarity in an epithelial cell layer\nDemonstrating a role for planar cell polarity in regulating intestinal epithelial migration\n\n\n\n  \n\n\n  \n\n\n \n\n\nPierre N’Guetta (O’Brien lab) \n\n\n\nTotal renal denervation in mice leads to a decrease in number of nephron developed\nDenervated kidneys exhibit impaired balance between self-renewal and differentiation of progenitor populations\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusionkeith-breau-pierre-nguetta/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250825T123000
DTEND;TZID=America/New_York:20250825T133000
DTSTAMP:20260603T083906
CREATED:20250822T194510Z
LAST-MODIFIED:20250822T194618Z
UID:10000449-1756125000-1756128600@www.med.unc.edu
SUMMARY:Monday - FUSION: Max Hockenberry & Christina So
DESCRIPTION:Max Hockenberry (Bear and Legant labs) \n\n\n\nWe have developed an imaging based approach to directly visualize the motion of single molecules of actin and the arp2/3 complex in living cells.\nWe have used this approach and preliminary data to assess how molecules of these proteins get to the front of the cell for incorporation in polymerizing actin networks at the leading edge.\n\n\n\n  \n\n\n  \n\n\n \n\n\nChristina So (Neher lab) \n\n\n\nANGPTL3 and ANGPTL8 are both lipoprotein inhibitors that form a complex in the cell prior to secretion. When not in complex\, ANGPTL8 gets trafficked to lysosomes\, and it is unknown how ANGPTL3 diverts ANGPTL8 from lysosomes.\n\n\n\n 
URL:https://www.med.unc.edu/cellbiophysio/event/monday-fusion-max-hockenberry-christina-so/
LOCATION:G202 MBRB\, 111 Mason Farm Rd\, Chapel Hill
CATEGORIES:FUSION Seminar Series
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