Tarran Lab Publications

Link to PubMed

Selected Publications:

  1. Turner MJ, Saint-Criq V, Patel W, Ibrahim SH, Verdon B, Ward C, Garnett JP, Tarran R, Cann MJ, Gray MA. Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia. J Physiol. 2015 Nov 17. doi: 10.1113/JP271309. [Epub ahead of print]
  2. Rowell TR, Tarran R. Will chronic e-cigarette use cause lung disease? Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1398-409.
  3. Manzanares D, Krick S, Baumlin N, Dennis JS, Tyrrell J, Tarran R, Salathe M. Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone. J Biol Chem. 2015 Oct 16;290(42):25710-6
  4. Ghosh A, Boucher RC, Tarran R. Airway hydration and COPD.Cell Mol Life Sci. 2015 Oct;72(19):3637-52. doi: 10.1007/s00018-015-1946-7. Epub 2015 Jun 12. Review.
  5. Choi HC, Kim CS, Tarran R. Automated acquisition and analysis of airway surface liquid height by confocal microscopy. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L109-18.
  6. Tyrrell J, Qian X, Freire J, Tarran R. Roflumilast combined with adenosine increases mucosal hydration in human airway epithelial cultures after cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1068-77.
  7. Xu X, Balsiger R, Tyrrell J, Boyaka PN, Tarran R, Cormet-Boyaka E. Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta. 2015 Jun;1850(6):1224-32.
  8. Åstrand AB, Hemmerling M, Root J, Wingren C, Pesic J, Johansson E, Garland AL, Ghosh A, Tarran R. Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition.Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L22-32. doi: 10.1152/ajplung.00163.2014. Epub 2014 Oct 31.
  9. Tan CD, Hobbs C, Sameni M, Sloane BF, Stutts MJ, Tarran R. Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures. J Physiol. 2014 Dec 1;592(23):5251-68.
  10. Helassa N, Garnett JP, Farrant M, Khan F, Pickup JC, Hahn KM, MacNevin CJ, Tarran R, Baines DL. A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration. Biochem J. 2014 Dec 1;464(2):213-20.
  11. Tyrrell J, Tarran R. Gaining the Upper Hand on Pulmonary Drug Delivery. J Pharmacovigil. 2014 Mar 1;2(1):118.
  12. Hassan F, Xu X, Nuovo G, Killilea DW, Tyrrell J, Da Tan C, Tarran R, Diaz P, Jee J, Knoell D, Boyaka PN, Cormet-Boyaka E. Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels. Respir Res. 2014 Jun 23;15:69.
  13. Tarran R, Redinbo MR. Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration. Int J Biochem Cell Biol. 2014 Jul;52:130-5. doi: 10.1016/j.biocel.2014.03.002. Epub 2014 Mar 13. Review.
  14. Rasmussen JE, Sheridan JT, Polk W, Davies CM, Tarran R.Cigarette smoke-induced Ca2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. J Biol Chem. 2014 Mar 14;289(11):7671-81.
  15. Garnett JP, Gray MA, Tarran R, Brodlie M, Ward C, Baker EH, Baines DL. Elevated paracellular glucose flux across cystic fibrosis airway epithelial monolayers is an important factor for Pseudomonas aeruginosa growth. PLoS One. 2013 Oct 4;8(10):e76283.
  16. Hobbs CA, Blanchard MG, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Redinbo MR, Stutts MJ, Tarran R. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L990-L1001.
  17. Schmid A, Clunes LA, Salathe M, Verdugo P, Dietl P, Davis CW, Tarran R. (2011.) Nucleotide-Mediated Airway Clearance. Chapter 5. In Purinergic Regulation of Respiratory Diseases. Eds, Picher, M, Boucher RC. Subcell Biochem. 2011;55:95-138.
  18. Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. (2012.) Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J. 2012 Feb;26(2):533-45. PMC3290447
  19. Sheridan JT, Worthington EN, Yu K, Gabriel SE, Hartzell HC, Tarran R. (2011.) Characterization of the Oligomeric Structure of the Ca2+-Activated Cl- Channel Ano1/TMEM16A. Journal of Biological Chemistry. 286(2):1381-8.
  20. Harvey PR, Tarran R, Garoff S, Myerburg MM. (2011.) Measurement of airway surface liquid volume with simple light refraction microscopy. American Journal Respiratory Cell and Molecular Biology. 2011 Sep; 45(3):592-9.
  21. Watson MJ, Worthington EN, Clunes LA, Rasmussen JE, Jones L, Tarran R. (2011.) Defective adenosine-stimulated cAMP production in cystic fibrosis airway epithelia: a novel role for CFTR in cell signaling. FASEB J. 2011 25(9):2996-3003.
  22. Gaillard E, Cabellero AG, Stutts MJ, Tarran R. (2010.) Regulation of airway surface liquid volume by proteases and their inhibitors. Pfleugers Arch. 460(1):1-17.
  23. Rollins BM, Garcia-Caballero A, Stutts MJ, Tarran R. (2010.) SPLUNC1 Expression Reduces ENaC Surface Levels in Xenopus Laevis Oocytes. Channels. 4(4):255-9.
  24. Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, Donaldson SH, Stutts MJ, Tarran R. (2009.) SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage. P.N.A.S. 106(27):11412-7.
  25. Coakley RD, Sun H, Clunes LA, Rasmussen JE, Stackhouse JR, Okada SF, Fricks I, Young SL, Tarran R. 17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia.  J Clin Invest. 2008 Dec;118(12):4025-35.

    Rollins BM, Burn M, Coakley RD, Chambers LA, Hirsh AJ, Clunes MT, Lethem MI, Donaldson SH, Tarran R. (2008) A2B Adenosine Receptors Regulate the Mucus Clearance Component of the Lungs Innate Defense System.  Am J Respir Cell Mol Biol. 39(2):190-7.
  26. Clunes LA, Bridges A, Alexis N, Tarran R. (2008) In vivo versus in vitro airway surface liquid nicotine levels following cigarette smoke exposure. J Anal Toxicol. 2008 Apr;32(3):201-7.
  27. Chambers LA, Rollins BM, Tarran R. (2007) Liquid movement across the surface epithelium of large airways. Respir Physiol Neurobiol. 159(3):256-70.
  28. Tarran R, Trout L, Donaldson SH, Boucher RC. (2006) Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia. J Gen Physiol. 127(5):591-604.
  29. Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R , Boucher RC. (2006) Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med. 354(3):241-50.
  30. Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC. (2005) Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. J. Biol. Chem. 280(42):35751-9.
  31. Thelin WR, Kesimer M, Tarran R, Kreda SM, Grubb BR, Sheehan JK, Stutts MJ, Milgram SL. (2005) The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A. J Biol Chem. 280(50):41512-20.
  32. Lazarowski ER, Tarran R, Grubb BR, van Heusden CA , Okada S, Boucher RC. (2004) Nucleotide release provides a mechanism for airway surface liquid homeostasis. J. Biol. Chem. 279(35):36855-64
  33. Tarran R. (2004) Regulation of Airway Surface Liquid Volume and Mucus Transport by Active Ion Transport. Proceedings of the American Thoracic Society. 1: 42–46.
  34. Roomans GM, Kozlova I, Nilsson H, Vanthanouvong V, Button B, Tarran R. (2004) Measurements of airway surface liquid height and mucus transport by fluorescence microscopy, and of ion composition by X-ray microanalysis. Journal of Cystic Fibrosis. S2, 135-9.
  35. Davidson DJ, Gray MA, Kilanowski FM, Tarran R, Randell SH, Sheppard DN, Argent BE, Dorin JR. (2004) Murine epithelial cells: isolation and culture. Journal of Cystic Fibrosis. S2, 59-62.
  36. Tarran R, Boucher RC. (2002) Thin-film measurements of airway surface liquid volume/composition and mucus transport rates in vitro . In: Methods in Molecular Medicine. (Skach, W.R. ed.) (Humana Press , NJ). 70, 479-92.
  37. Tarran R, Loewen ME, Paradiso AM, Olsen JC, Gray MA, Argent BE, Boucher RC, Gabriel SE. (2002) Regulation of murine airway surface liquid volume by CFTR and Ca2+-activated Cl- conductances. Journal of General Physiology, 120, 3-15.
  38. Tarran R*, Worlitzsch D*, Ulrich M*, Schwab U, Cekici A, Meyer KC, Birrer P, Bellon G, Berger J, Weiss T, Botzenhart K, Yankaskas JR, Randell S, Boucher RC, Döring G. (2002) Effects of reduced mucus oxygen concentration in airway Pseudomonas aeruginosa infections of cystic fibrosis patients. Journal of Clinical Investigation. 109, 317-325. (*Joint First Authorship).
  39. Caldwell RA, Grubb BR, Tarran R, Boucher RC, Knowles MR, Barker PM. (2002) In Vivo Airway Surface Liquid Cl- Analysis with Solid-state Electrodes. Journal of General Physiology, 119 (1) ,3-14.
  40. Huang P, Lazarowski ER, Tarran R, Milgram SL, Boucher RC, Stutts MJ. (2001) Compartmentalized autocrine signalling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. P.N.A.S. 98(24), 14120-5.
  41. Tarran R, Grubb BR, Gatzy JT, Davis CW, Boucher RC. (2001) Relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition.  Journal of General Physiology, 118(2), 223-236.
  42. Tarran R, Grubb BR, Parsons D, Picher M, Hirsh AJ, Davis CW, Boucher RC. (2001) The CF salt controversy: Implications for therapies designed to correct abnormalities in CF airway surface liquid based on in vivo and in vitro studies. Molecular Cell, 8(1), 149-158.