Curriculum Vitae

CURRICULUM VITAE

David L. McIlwain

Department of Cell and Molecular Physiology

University of North Carolina School of Medicine

Chapel Hill, North Carolina 27599

Birthplace and date: Memphis, Tennessee USA , 1938

Home: 8 Gooseneck Road, Chapel Hill

Education:

B.A., Philosophy, Vanderbilt University, Nashville, Tennessee, 1960.

M.D., Washington University School of Medicine, St. Louis, Missouri, 1964.

Postdoctoral Fellow in Biochemistry. University of California at Berkeley. (C.E. Ballou). Chemistry of phospholipids and glycolipids. September, 1964 – April, 1966.

Postdoctoral Fellow in the Neurosciences. Columbia University College of Physicians and Surgeons, Division of Neuroscience, New York State Psychiatric Institute. (M.M. Rapport). Experimental approaches to myelin degradation. July, 1968 – June, 1972.

Academic Employment History:

Department of Cell and Molecular Physiology, Univ. of North Carolina at Chapel Hill

Professor Emeritus, 2005 –

Professor, 1984-2004.

Associate Professor, 1977-1984.

Assistant Professor, 1972-1977.

Faculty Member, The Graduate School, 1972-2004.

Faculty Member, The Neurobiology Curriculum, 1972-2004.

Teaching:

Medical and Related Courses:

Physiology 92 (Nursing), 1972-1976. Ten lecture hours each year on nerve and muscle cell physiology, membrane transport mechanisms, fluid and electrolytes balance, special senses.

Cell Biology (Medical Students I), 1973-1977. 13.5 lecture hours and 10 laboratory hours each year on membrane structure and function, electrical excitability and muscle physiology.

Medical Physiology 130 (Spring, Medical Students I), 1985-2004. Course Director 1985-1990; 2001-2003); lecturer and weekly small group leader for 16 students. 6 lecture hours on membrane transport, electrical properties of membranes and neuromuscular transmission. 16 hours of laboratory small groups throughout the course in cell, cardiovascular, respiratory, endocrine and renal physiology.

Medical Neurobiology 201 (Spring, Medical Students I), 1994-2004. Lecturer and neuroanatomy lab instructor for 32 students (1996-2001; 2004). Lectures: Aging in the nervous system (1h), Age-dependent neurodegenerative diseases and dementia (1h). Laboratory instruction: 24 hours throughout the course.

Medical Problems (Medical Students II), 1992-1994. 24 seminar hours as tutor in case studies.

Physiology 93 (Fall, Pharmacy Students I), 1998-2004. Three lecture hours, one hour review on respiratory physiology.

Physiology 114 (Spring, Dental Students I), 2004. Eight lecture hours, cardiovascular physiology.

Graduate Courses:

Physiology 140 (Graduate Students), 1975-1983. Course Director, 1983. Five to 9 lecture hours each year on membrane structure and function, gastrointestinal physiology and respiratory physiology.

Physiology 202 (Graduate Students), 1980, 1982, 1984, 1988. 4.5 – 10.5 seminar hours each year on protein synthesis, secretory mechanisms in cells.

Physiology 240 (Graduate Students), 1991, 1992. 10 seminar hours each year on advanced cell physiology.

Other Teaching:

Faculty Mentor, UNC Minority Pre-Graduate Research Experience Program, summer 1990

Faculty Mentor, NC School of Science and Mathematics Mentorship Program; six students, 1983-1992.

Faculty Mentor, Medical Scholars Program, 1994-1995.

Mentor, Research Apprenticeship Program (RAP) for high school juniors or seniors, summers of 1998, 1999, 2001, 2003.

Invited lectures in Neurobiology 107, Graduate Nursing Seminar, Neuroanatomy 101, Neurobiology 227 and Medical Physiology (East Carolina School of Medicine) 1972 -1980. Average of 2 hours each.

Graduate Training:

Director of Graduate studies in Physiology, 1977-1982.

Chairman of Review of Graduate Program in Physiology, 1986.

Member, Departmental Graduate Committee, 1987-1992.

Dissertation Advisor and Chairman, Ph.D. Dissertation Committee for David E. Weil (Neurobiology), 1976-1979.

Dissertation Advisor and Chairman, Ph.D. Dissertation Committee for Stephen B. Burgess (Neurobiology), 1991-1993.

Member, Ph.D. Dissertation Committees (Physiology, Neurobiology, Biochemistry and Pharmacology) – 21 students, 1973-1997

Faculty Mentor for two graduate teaching assistants in Medical Physiology small groups, 1998 and 2001.

Faculty Mentor for five graduate teaching assistants in Medical Neurobiology small groups, 1997-2001.

Teaching Awards:

Hyman L. Battle Distinguished Excellence in Teaching Award in the Basic Sciences, 1988; 1999 (voted upon by first- and second-year medical students)

Freshman Basic Science Teaching Award, 1999; 2001 (voted upon by first-year medical students)

School of Medicine Teaching Excellence Award, 2001; 2004 (nominated by department chair, selected by School of Medicine)

Whitehead Lecturer, 2001 (voted upon by all medical students)

University Distinguished Teaching Award for Post-Baccalaureate Instruction, 2002

Research: Structure and chemistry of spinal motoneurons

Research Awards:

Kenan Research Professorship, September, 1982 – February, 1983, for research and study at the Tokyo Metropolitan Institute for Gerontology.

Javits Neuroscience Investigator Award, January 1986 – December 1992.

Short Term Fellow, Japan Society for the Promotion of Science, June 1986, for research at the National Institute for Physiological Sciences, Okazaki, Japan.

Professional Service:

School of Medicine

Member, Pharmacology Chair Search Committee, 1975-1976.

Member, Medical Dean Search Committee, 1978-1979.

Member, Medical Sciences Lecture Committee, 1975 to 1984. Chair, 1980-1984. Member, Basic Sciences Examination Committee. 1976-1980.

Member, Institutional Self-Study, School of Medicine. Task Forces on Graduate Education and Resources and Physical Plant, 1979.

Member, Department of Neurology Review Committee,1980-1981.

Member, Executive Committee, Neurobiology Curriculum, 1973-1983.

Member, M.D./Ph.D. Curriculum Planning Committee, 1981-1982.

Member, Representative Group on Health Promotion/Disease Prevention, 1984.

Member, Committee to Review Appointments and Promotions to Full Professor, 1984-1988. Chair, 1987-1988.

Member, Brain Development Research Center Director Search Committee, 1984-1985.

Member, Committee to Review Program on Aging, 1985.

Member, Search Committee for Director of Program on Aging 1986.

Chair, Committee to Review Space Assignments in the School of Medicine, 1986-1987.

Member, Committee to Study the Chair Review Process, 1988-1989.

Member, Program on Aging Advisory Board/Task Force Committee, 1988-1997.

Member, Advisory Committee on Medical Practice and Education in the 21st Century, 1989-1991.

Member, Search Advisory Committee for the Assistant Dean for Student Affairs, 1990.

Member, Committee for Five-Year Review of the Director, Brain and Development Research Center, 1990.

Member, Committee on Medical Education of the 21st Century, 1992.

Member, Program Planning Committee of the School of Medicine, 1991-1994.

Member, Committee for Five-Year Review of the Director, Program on Aging, 1992.

Member, Search Committee for Director, Center for Alcohol Studies, 1992-1994.

Member, Committee for Five-Year Review of the Chair, Department of Pathology and the Director of the Division of Laboratory Medicine, 1993.

Member, Task Force on International Medicine, 1993-1994

Member, Committee on Adjustment to Financial Adversity, 1993-1994.

Member, Holderness Fellows Selection Committee, 1996.

Member, Subcommittees on Institutional Objectives and on the Educational Program

Leading to the MD Degree, Self-Study Task Force for LCME Accreditation, 1996.

Medical Student Advisor, 1998-2004.

Interviewer, Medical School Applicants for Class of 2003, 1998 -1999.

Member, Committee to Review Student International Fellowship Applications, 1999 -2004.

Member, Norma Berryhill Distinguished Lecture Selection Committee, 2002-2004; Chair, 2003-2004.

Member, Subcommittee on Institutional Objectives and on the Educational Program Leading to the MD Degree, Self-Study Task Force for LCME Accreditation, 2003.

University

Member, Administrative Board of the Graduate School, 1981. Subcommittees: Biomedical Research Assistantships, Graduate Courses, Smith Fund Grants.

Member, Health Sciences Advisory Committee on Appointments and Promotions, 1987-1988.

Member, Vice-Chancellor’s Committee on Fixed -Term Appointments in Health Affairs, 1994-1995.

Member, University Committee on Teaching Awards, 1995 -1996; Chair, 1996-1997.

Chair, Committee to Review the Director of the Center for Teaching and Learning, 1998.

Member, Committee on Conflicts of Interest and Commitment, 1997-2004; Chair, 1999-2004.

Founding Fellow, UNC Institute on Aging, 1999.

Grant Reviewer, UNC Institute on Aging, 2000, 2001.

State

Faculty Fellow, North Carolina Japan Center, Raleigh, North Carolina. 1981 –

Ad hoc research advisor to the North Carolina Chapter of the Amyotrophic Lateral Sclerosis Association, 1985-2004

Councilor, NC Chapter, Society for Neuroscience, 1994-1998.

National

Member, Scientific Advisory Committee, ALS Society of America. 1981-1984.

Ad Hoc Member, Neurology B1 Study Section, NIH/NINCDS, 1987.

Regular Member, Neurology B1 Study Section, NIH/NINDS, 1988-1992.

Other

Acting Co-Chairman, Department of Physiology, January – June, 1980; June – July, 1985.

Publications:

Mcllwain, D.L. and C.E. Ballou (1966). “Characterization of Phospholipids of Pinus Ponderosa Pollen.” Biochemistry 5, 4054-4061.

Mcllwain, D.L. and M.M. Rapport (1971) “Effects of Phospholipase C on Purified Myelin.” Biochim. Biophys. Acta 239, 71-80.

Mcllwain, D.L., L. Graf and M.M. Rapport (1971). “Fragmentation of Myelin by Different Detergents.” J. Neurochem. 18, 2255-2263.

Mcllwain, D.L. (1973). “Non-osmotic Swelling in Purified Bovine Myelin.” Brain Res. 52, 97-113.

Coles, E., D.L. McIlwain and M.M. Rapport (1974). “Effects of Phospholipase A2 on Purified Myelin and Phospholipids.” Biochim.Biophys. Acta 337, 68-78.

McIlwain, D.L. (1974). “Localization of Acetylcholinesterase-containing Membranes in Purified Myelin Fractions.” Brain Res. 69,182-187.

Capps-Covey, P. and D.L. McIlwain (1975). “Bulk Isolation of Large Ventral Spinal Neurons.” J. Neurochem. 25, 517-521.

McIlwain, D.L. and P. Capps-Covey (1976). “The Nuclear DNA Content of Large Ventral Spinal Neurons.” J. Neurochem. 27, 109-112.

Weil, D.E., W.H. Busby, Jr. and D.L. McIlwain (1977). “Choline Acetyltransferase Activity in Large Ventral Spinal Neurons.” J. Neurochem. 29, 847-852.

Hester, S., P. Capps-Covey and D.L. McIlwain (1978). “The Plasma Membrane of Bulk-Isolated Mature Spinal Neurons.” Brain Res. 159, 41-54.

Mcllwain, D.L. and P.B. Farel (1979). “Initiation and Time Course of Mitosis of Non-neuronal Cells after Spinal Motoneuron Axotomy.” Brain Res. 178, 519-528.

Weil, D.E. and D.L. McIlwain (1981). “Distribution of Soluble Proteins within Spinal Motoneurons: A Quantitative Two-Dimensional Electrophoretic Analysis.” J. Neurochem. 36, 242-250.

Aycock, B.F., D.E. Weil, D.V. Sinicropi and D.L. Mcllwain (1981). “Television-Based Densitometric Analysis of Proteins Separated by Two-Dimensional Gel Electrophoresis.” Computers and Biomed. Res. 14, 314-326.

Sinicropi, D.V., K. Michels and D.L. McIlwain (1982). “Distribution of Acetylcholinesterase in Axotomized Frog Motoneurons.” J. Neurochem. 38, 1099-1105.

Sinicropi, D.V. and Mcllwain, D.L. (1983). “Changes in the Amounts of Cytoskeletal Proteins within the Perikarya and Axons of Regenerating Frog Motoneurons.” J. Cell Biol. 96, 240-247.

Farel, Paul B. and McIlwain, D.L. (1983). “Cholinergic Enzyme Activity in Neurons of the Developing Anuran Spinal Cord.” Develop. Brain Res. 8: 275-282.

Brock, T.O. and McIlwain, D.L. (1984) “Astrocytic Proteins in the Dorsal and Ventral Roots in Amyotrophic Lateral Sclerosis and Werdnig-Hoffmann Disease.” J.Neuropathol. Exper. Neurol. 43, 609-619.

Brock, T.O. and McIlwain, D.L. (1985). “Relative Postmortem Stability of Spinal Motoneuronal Proteins Detectable by Two-Dimensional Electrophoresis.” Neurochem. Pathol. 3, 1-14.

McIlwain, D.L. and Hoke, V.B. (1988). “Allocation of Newly Synthesized Proteins in Spinal Motoneurons.” Rev. Neurol. (Paris) 144, 697-700.

Sinicropi, D.V., Hoke, V.B. and McIlwain, D.L. (1989). “Isolation of Motoneuron Cell Bodies from Spinal Cord Stored at -70 C in Ethylene Glycol.” Anal. Biochem. 180, 286-290.

McIlwain, D.L. (1991). “Nuclear and Cell Body Size in Spinal Motoneurons.” Adv. Neurol. 56, 67-74.

Sato, S., Burgess, S.B. and McIlwain (1994). “Transcription and Motoneuron Size,” J. Neurochem. 63, 1609-1615.

McIlwain, D.L. and Hoke, V.B. (1994). “Radiolabeling Motoneuronal Proteins in the Isolated Frog Spinal Cord Preparation,” J. Neurosci. Methods 52, 19-202.

Burgess, S.B. and McIlwain, D.L. (1994). “Synchronous, intersegmental responses in motoneurons to lumbar ventral root injury,” NeuroReport 5, 2641-2644.

Chen, L., Lund, P.K., Burgess, S.B., Rudisch, B. E. and McIlwain, D.L. (1997). “Growth Hormone, IGF-1 and Motoneuron Size,” J. Neurobiol. 32, 202-212.

McIlwain, D.L. and Hoke, V.B. (1999).“Magnitude, Laterality and Uniformity of Swelling in Axotomized Spinal Motoneurons: Lack of Evidence for Influence by the Distal Stump.” Exp. Neurol. 157: 161-168.

Farel, Paul B. and McIlwain, D.L. (2000). “Neuron Addition and Enlargement in Juvenile and Adult Animals.” (Review) Brain Res. Bull. 53: 537-546.

McIlwain, D.L., Hoke, V.B., Kopchick, J.J., Fuller, C.R. and Lund, P.K. (2004). “Differential Inhibition of Postnatal Brain, Spinal Cord and Body Growth by a Growth Hormone Antagonist.” BMC Neurosci. 5: 6

McIlwain, D.L. and Hoke, V.B. (2005). “Role of the Cytoskeleton in Nucleolar, Nuclear and Cell Body Enlargement, Increased Nuclear Eccentricity and Chromatolysis in Axotomized Spinal Motor Neurons.” BMC Neurosci. 6:19