{"id":11101,"date":"2020-09-16T14:41:51","date_gmt":"2020-09-16T18:41:51","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/?post_type=directory&#038;p=11101"},"modified":"2024-08-16T12:42:53","modified_gmt":"2024-08-16T16:42:53","slug":"richard-loeser-md","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/richard-loeser-md\/","title":{"rendered":"Richard Loeser, MD"},"content":{"rendered":"<p>Dr. Loeser\u2019s primary research goal is to discover the basic mechanisms relevant to joint tissue destruction in osteoarthritis. Osteoarthritis (OA) is the leading cause of pain and disability in older adults. A better mechanistic understanding of OA is needed in order to develop interventions that can slow or stop disease progression before advanced joint tissue destruction occurs. The lab uses a combination of <em>in vitro<\/em> experiments in human joint tissue cells and <em>in vivo<\/em> experiments in mouse models to study cell signaling pathways that regulate anabolic and catabolic activity responsible for joint tissue remodeling and destruction. Projects in the lab include studies of the cell signaling pathways activated by the interaction of fibronectin fragments with the \u03b15\u03b21 integrin on chondrocytes. Fibronectin fragments, found in arthritic cartilage and synovial fluid, generate signals that result in up-regulation of a number of matrix degrading enzymes, cytokines, and chemokines that are relevant to OA. Another major project in the lab is to study the mechanism for chondrocyte IGF-1 resistance that is seen with aging and the development of OA. The lab is particularly interested in determining how reactive oxygen species regulate chondrocyte signaling downstream of integrins, cytokines and growth factors through the oxidation of specific cysteine residues in kinases and phosphatases as well as other intracellular proteins. The lab is studying how oxidative stress that occurs with aging and joint injury can alter the activity of these signaling pathways with the goal of finding new signaling targets for small molecule inhibitors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Loeser\u2019s primary research goal is to discover the basic mechanisms relevant to joint tissue destruction in osteoarthritis. Osteoarthritis (OA) is the leading cause of pain and disability in older adults. A better mechanistic understanding of OA is needed in order to develop interventions that can slow or stop disease progression before advanced joint tissue &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/richard-loeser-md\/\" aria-label=\"Read more about Richard Loeser, MD\">Read more<\/a><\/p>\n","protected":false},"featured_media":11102,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-11101","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Richard Loeser, MD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/richard-loeser-md\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Richard Loeser, MD - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Dr. Loeser\u2019s primary research goal is to discover the basic mechanisms relevant to joint tissue destruction in osteoarthritis. 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Archie, Jr. Eminent Professor\r\n<em>Medicine<\/em>\r\nOffice:\u00a0 3300 Thurston Bowles\r\nOffice phone:\u00a0 866-827-2862\r\n<a href=\"mailto:richard_loeser@med.unc.edu\">Email<\/a>\r\n<a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/richard-f-loeser-jr-md\/\">Webpage<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"richard_loeser@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"866-827-2862"}]],"_upd_address":[[{"address":{"address-1":"3300 Thurston Bowles","address-2":"","campus-box":"7280","city":"Chapel Hill","state":"NC","zip":"27599-7280"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11101\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media\/11102"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media?parent=11101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}