{"id":11630,"date":"2021-02-22T16:27:57","date_gmt":"2021-02-22T21:27:57","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/?post_type=directory&p=11630"},"modified":"2021-02-22T16:27:57","modified_gmt":"2021-02-22T21:27:57","slug":"joan-m-taylor-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/","title":{"rendered":"Joan M. Taylor, PhD"},"content":{"rendered":"

Research Interests<\/strong><\/h2>\n
    \n
  1. Regulation of vessel development (Arteriogenesis) and vessel tone (Hypertension)<\/li>\n
  2. Regulation of Cardiac Growth and the Pathogenesis of Cardiac Disease (Myocardial Infarction)<\/li>\n
  3. Regulation of Skeletal Muscle Formation and Degeneration (Muscular Dystrophies)<\/li>\n<\/ol>\n

    General Research Program of the Taylor Lab<\/b><\/h2>\n

    The overall goal of our research is to characterize the intracellular signaling pathways that govern normal and aberrant growth responses in the cardiovascular and musculoskeletal system. We study cell-type specific signaling pathways that regulate coordinated development of the heart and vascular system as well as the pathogenesis of cardiovascular disease and muscular dystrophies. The laboratory is specifically interested in the intracellular signals initiated by receptors involved in sensing and responding to the surrounding extracellular matrix. Adhesion-dependent clustering of specific transmembrane integrin receptors initiates the recruitment of numerous proteins to their cytoplasmic tails that include both structural and catalytically active signaling proteins and their activation culminates in changes in cell growth, survival, differentiation, and motility. We focus on the non-receptor protein tyrosine kinase, focal adhesion kinase (FAK) and FAK binding partners since activation of FAK within focal adhesions is central to the integrin-dependant signaling. Moreover, our lab has defined a critical role for FAK signaling in cardiovascular development and disease progression. We are now interested in how FAK and associated focal adhesion proteins coordinate the spatial and temporal activation of mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NFkB), and Rho family GTPases and how these signals are integrated to enable appropriate changes in cellular morphology and gene transcription. Our laboratory uses transgenic mouse models and gene knock-out technology coupled with surgical approaches (to interrogate injury response and repair mechanisms) as well as state-of-the art cell biology approaches to track dynamic molecular and cellular processes in real-time. See vascular<\/a>, cardiac<\/a>, or skeletal muscle<\/a> for specific research projects.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Research Interests Regulation of vessel development (Arteriogenesis) and vessel tone (Hypertension) Regulation of Cardiac Growth and the Pathogenesis of Cardiac Disease (Myocardial Infarction) Regulation of Skeletal Muscle Formation and Degeneration (Muscular Dystrophies) General Research Program of the Taylor Lab The overall goal of our research is to characterize the intracellular signaling pathways that govern normal … Read more<\/a><\/p>\n","protected":false},"featured_media":11629,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-11630","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nJoan M. Taylor, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Joan M. Taylor, PhD - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Research Interests Regulation of vessel development (Arteriogenesis) and vessel tone (Hypertension) Regulation of Cardiac Growth and the Pathogenesis of Cardiac Disease (Myocardial Infarction) Regulation of Skeletal Muscle Formation and Degeneration (Muscular Dystrophies) General Research Program of the Taylor Lab The overall goal of our research is to characterize the intracellular signaling pathways that govern normal … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"188\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/\",\"name\":\"Joan M. Taylor, PhD - Department of Cell Biology and Physiology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg\",\"datePublished\":\"2021-02-22T21:27:57+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg\",\"width\":188,\"height\":250,\"caption\":\"Joan Taylor\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Joan M. Taylor, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\",\"name\":\"Department of Cell Biology and Physiology\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Joan M. Taylor, PhD - Department of Cell Biology and Physiology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/","og_locale":"en_US","og_type":"article","og_title":"Joan M. Taylor, PhD - Department of Cell Biology and Physiology","og_description":"Research Interests Regulation of vessel development (Arteriogenesis) and vessel tone (Hypertension) Regulation of Cardiac Growth and the Pathogenesis of Cardiac Disease (Myocardial Infarction) Regulation of Skeletal Muscle Formation and Degeneration (Muscular Dystrophies) General Research Program of the Taylor Lab The overall goal of our research is to characterize the intracellular signaling pathways that govern normal … Read more","og_url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/","og_site_name":"Department of Cell Biology and Physiology","og_image":[{"width":188,"height":250,"url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/","name":"Joan M. Taylor, PhD - Department of Cell Biology and Physiology","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg","datePublished":"2021-02-22T21:27:57+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/02\/Joan-Taylor.jpeg","width":188,"height":250,"caption":"Joan Taylor"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/joan-m-taylor-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/cellbiophysio\/"},{"@type":"ListItem","position":2,"name":"Joan M. Taylor, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/","name":"Department of Cell Biology and Physiology","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_upd_display_name":["Joan M. Taylor, PhD"],"_upd_reverse_display_name":["Taylor, Joan"],"_upd_last_name":["Taylor"],"_upd_first_name":["Joan"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Professor<\/strong>\r\n<em>Pathology<\/em>\r\nOffice:\u00a0 501 Brinkhous-Bullitt Bldg.\r\nPhone:\u00a0 919-843-5511\r\n<a href=\"mailto:joan_m_taylor@med.unc.edu\">Email<\/a> | <a href=\"https:\/\/www.med.unc.edu\/pathology\/taylorlab\/\">Webpage<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"joan_m_taylor@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-5511","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"501 Brinkhous-Bullitt Bldg.","address-2":"","campus-box":"7525","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11630\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media\/11629"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media?parent=11630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}