{"id":11737,"date":"2021-04-12T15:44:56","date_gmt":"2021-04-12T19:44:56","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/?post_type=directory&#038;p=11737"},"modified":"2021-04-12T15:44:56","modified_gmt":"2021-04-12T19:44:56","slug":"alan-m-jones-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/","title":{"rendered":"Alan M. Jones, PhD"},"content":{"rendered":"<h2>Research Interests<\/h2>\n<ul>\n<li>Signal Perception and the Regulation of Growth and Development<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>The Jones lab is interested in heterotrimeric G protein-coupled signaling and uses genetic model systems to dissect signaling networks. The G-protein complex serves as the nexus between cell surface receptors and various downstream enzymes that ultimately alter cell behavior. Metazoans have a hopelessly complex repertoire of G-protein complexes and cell surface receptors so we turned to the reference plant,\u00a0<i>Arabidopsis thaliana<\/i>, and the yeast,\u00a0<i>Saccharomyces cerevisiae<\/i>, as our models because these two organisms have only two potential G protein complexes and few cell surface receptors. Their simplicity and the ability to genetically \u201cknock out\u201d or \u201cknock up\u201d the expression of genes in these organisms make them powerful tools. At present, we are most interested in novel signaling networks that are used for sensing sugars and other networks used to sense extracellular nucleotides. Our work shows the great plasticity of the activation mechanism in eukaryotic cells. \u00a0We work closely with several other labs in the Dept. of Pharmacology and use a variety of cell biology approaches, including sophisticated imaging techniques, 3-D protein structure analyses, forward and reverse genetic approaches, biochemistries, and mathematical modeling.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Signal Perception and the Regulation of Growth and Development Research Synopsis The Jones lab is interested in heterotrimeric G protein-coupled signaling and uses genetic model systems to dissect signaling networks. The G-protein complex serves as the nexus between cell surface receptors and various downstream enzymes that ultimately alter cell behavior. Metazoans have a &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/\" aria-label=\"Read more about Alan M. Jones, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":11736,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-11737","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alan M. Jones, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alan M. Jones, PhD - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Research Interests Signal Perception and the Regulation of Growth and Development Research Synopsis The Jones lab is interested in heterotrimeric G protein-coupled signaling and uses genetic model systems to dissect signaling networks. The G-protein complex serves as the nexus between cell surface receptors and various downstream enzymes that ultimately alter cell behavior. Metazoans have a &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"130\" \/>\n\t<meta property=\"og:image:height\" content=\"150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/\",\"name\":\"Alan M. Jones, PhD - Department of Cell Biology and Physiology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg\",\"datePublished\":\"2021-04-12T19:44:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg\",\"width\":130,\"height\":150,\"caption\":\"Alan Jones\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Alan M. Jones, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\",\"name\":\"Department of Cell Biology and Physiology\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alan M. Jones, PhD - Department of Cell Biology and Physiology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/","og_locale":"en_US","og_type":"article","og_title":"Alan M. Jones, PhD - Department of Cell Biology and Physiology","og_description":"Research Interests Signal Perception and the Regulation of Growth and Development Research Synopsis The Jones lab is interested in heterotrimeric G protein-coupled signaling and uses genetic model systems to dissect signaling networks. The G-protein complex serves as the nexus between cell surface receptors and various downstream enzymes that ultimately alter cell behavior. Metazoans have a &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/","og_site_name":"Department of Cell Biology and Physiology","og_image":[{"width":130,"height":150,"url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/","name":"Alan M. Jones, PhD - Department of Cell Biology and Physiology","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg","datePublished":"2021-04-12T19:44:56+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg","contentUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2021\/04\/jones.jpg","width":130,"height":150,"caption":"Alan Jones"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/alan-m-jones-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/cellbiophysio\/"},{"@type":"ListItem","position":2,"name":"Alan M. Jones, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/","name":"Department of Cell Biology and Physiology","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_upd_display_name":["Alan M. Jones, PhD"],"_upd_reverse_display_name":["Jones, Alan M."],"_upd_last_name":["Jones"],"_upd_first_name":["Alan"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Kenan Distinguished Professor<\/strong>\r\n<em>Biology<\/em>\r\nOffice:\u00a0 312 Coker Hall\r\nOffice Phones:\u00a0 919-962-6932\r\n<a href=\"mailto:alan_jones@unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"alan_jones@unc.edu"}]],"_upd_phone":[[{"phone_text":"919-962-6932","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"312 Coker Hall","address-2":"","campus-box":"7365","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11737\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media\/11736"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media?parent=11737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}