{"id":11747,"date":"2021-04-12T16:16:49","date_gmt":"2021-04-12T20:16:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/?post_type=directory&#038;p=11747"},"modified":"2021-04-12T16:16:49","modified_gmt":"2021-04-12T20:16:49","slug":"shaun-d-mccullough-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/shaun-d-mccullough-phd\/","title":{"rendered":"Shaun D. McCullough, PhD"},"content":{"rendered":"<p>Dr. McCullough\u2019s lab takes a translational research approach that incorporates primary cell and organotypic\u00a0<em>in vitro<\/em>\u00a0models with clinical research (controlled human exposures) to study the role of cellular and molecular mechanisms in mediating the local and systemic effects of exposure to inhaled chemicals.\u00a0 His laboratory utilizes primary cell\/organotypic\u00a0<em>in vitro<\/em>\u00a0models, live cell imaging of fluorescent biosensors, and both traditional and advanced molecular biology\/biochemistry methods to characterize the relationship between redox dysfunction\/oxidative stress, inflammation, cell signaling pathway activation, epigenetic changes, gene expression, and cell-specific functional outcomes.\u00a0 In addition to identifying the mechanisms involved in the effects of toxic exposures, Dr. McCullough\u2019s research also aims to identify biomarkers of toxic exposure effects, predicting susceptible populations, and identifying factors that can be used to mitigate adverse exposure outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. McCullough\u2019s lab takes a translational research approach that incorporates primary cell and organotypic\u00a0in vitro\u00a0models with clinical research (controlled human exposures) to study the role of cellular and molecular mechanisms in mediating the local and systemic effects of exposure to inhaled chemicals.\u00a0 His laboratory utilizes primary cell\/organotypic\u00a0in vitro\u00a0models, live cell imaging of fluorescent biosensors, and &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/shaun-d-mccullough-phd\/\" aria-label=\"Read more about Shaun D. McCullough, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":11745,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-11747","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Shaun D. McCullough, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/shaun-d-mccullough-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Shaun D. 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McCullough, PhD"],"_upd_reverse_display_name":["McCullough, Shaun D."],"_upd_last_name":["McCullough"],"_upd_first_name":["Shaun"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Principal Investigator<\/strong>\r\n<em>Toxicology\/EPA<\/em>\r\nOffice:\u00a0 432 EPA\r\nOffice Phone:\u00a0 919-843-8031\r\n<a href=\"mailto:mccullough.shaun@epa.gov\">Email<\/a> | <a href=\"https:\/\/www.linkedin.com\/in\/shaun-d-mccullough-phd-96308513b\/\">Webpage<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"McCullough.Shaun@epa.gov"}]],"_upd_phone":[[{"phone_text":"919-843-8031","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"432 Environmental Protection Agency","address-2":"","campus-box":"","city":"Chapel Hill","state":"NC","zip":"27514"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/11747\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media\/11745"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media?parent=11747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}