{"id":15377,"date":"2025-07-02T12:22:29","date_gmt":"2025-07-02T16:22:29","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/?post_type=directory&#038;p=15377"},"modified":"2025-07-02T12:23:22","modified_gmt":"2025-07-02T16:23:22","slug":"ellen-r-weiss-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/ellen-r-weiss-phd\/","title":{"rendered":"Ellen R. Weiss, PhD"},"content":{"rendered":"<p>Emeritus<br \/>\nUNC-Chapel Hill<\/p>\n<div>\n<h2>Education and Training<\/h2>\n<p>Franklin and Marshall College, BA, 1978<br \/>\nUniversity of Tennessee, PhD, 1985<br \/>\nUniversity of Massachusetts Medical Center, Postdoctoral, 1985-1988<br \/>\nNational Jewish Center, Postdoctoral, 1988-1989<\/p>\n<h2>Research Area<\/h2>\n<p>Understanding the mechanism of visual signal transduction in the vertebrate retina<\/p>\n<h2>Research Highlights<\/h2>\n<ul>\n<li>Led one of the first research groups to clone the G protein-coupled receptor kinase seven (GRK7) and identify its function as a cone opsin kinase<\/li>\n<li>Defined the heterogeneity of GRK1 and GRK7 expression in vertebrates, leading to a re-evaluation of the appropriate models for human cone phototransduction. This work helped clarified differences in the pathophysiology of the retinas of patients with Oguchi disease patients and its mouse model<\/li>\n<li>Led one of the first research groups to apply metabolomics and proteomics to investigate the role of cellular metabolism on neurodegenerative retinal diseases<\/li>\n<\/ul>\n<h2>Selected Publications<\/h2>\n<p>Chrispell, J.D., Xiong, Y., &amp;Weiss, E.R. <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(22)01079-1\/fulltext\">Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebra sh cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP<\/a>. <em>J. Biol. Chem. <\/em>298(12) 102636 (2022).<\/p>\n<p>Osawa, S., Jo, R., Xiong, Y., et al. <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(19)49155-2\/fulltext\">Phosphorylation of G Protein-coupled receptor kinase 1 (GRK1) Is regulated by light but independent of phototransduction in rod photoreceptors<\/a>. <em>J. Biol. Chem.<\/em> 286(23), 20923-20929 (2011).<\/p>\n<p>Osawa, S., Jo, R., Weiss, E.R. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2008.05691.x\">Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light<\/a>. <em>J. Neurochem.<\/em> 107, 1314-1324 (2008).<\/p>\n<p>Horner, T.J., Osawa, S., Schaller, M.D., &amp; Weiss, E.R. <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(20)56520-4\/fulltext\">Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities<\/a>. <em>J. Biol. Chem<\/em> 280(31), 28241-2850 (2005).<\/p>\n<p><em>For a full list of publications, please see this <a href=\"https:\/\/orcid.org\/0000-0002-7304-013X\">link<\/a>.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Emeritus UNC-Chapel Hill Education and Training Franklin and Marshall College, BA, 1978 University of Tennessee, PhD, 1985 University of Massachusetts Medical Center, Postdoctoral, 1985-1988 National Jewish Center, Postdoctoral, 1988-1989 Research Area Understanding the mechanism of visual signal transduction in the vertebrate retina Research Highlights Led one of the first research groups to clone the G &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/ellen-r-weiss-phd\/\" aria-label=\"Read more about Ellen R. Weiss, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":9772,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-15377","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ellen R. Weiss, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/ellen-r-weiss-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ellen R. 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