{"id":4660,"date":"2016-08-15T14:54:00","date_gmt":"2016-08-15T18:54:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/"},"modified":"2024-01-08T13:03:48","modified_gmt":"2024-01-08T18:03:48","slug":"carol-otey-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/","title":{"rendered":"Carol Otey, PhD"},"content":{"rendered":"<p><!-- title_affiliation --><\/p>\n<p>Professor<br \/>\nUNC-Chapel Hill<\/p>\n<div>\n<h3>Education and Training<\/h3>\n<p>UCLA, PhD<\/p>\n<h3>Areas of Interest<\/h3>\n<p>My research program is focused on a fundamental property of cells, which is their ability to move. We want to understand how cells make the decision to either migrate or to remain stationary and adherent, and we are working to apply this knowledge to specific conditions, such as wound-healing and tissue remodeling after injury; cancer metastasis (which results from dis-regulated cell migration); and fibrosis (a state of dis-regulated wound-healing). In order to gain new insights into the mechanisms that control these processes, my lab has pursued collaborations that span from the molecular level to the patient level. Since 2007, I have worked closely with my major clinical collaborator, Dr. Hong Jin Kim, who is a surgical oncologist; in addition, my lab has formed interdisciplinary teams with protein biochemists, biophysicists, and clinician-scientists from multiple specialties. We are currently focusing on a specific variant (isoform 4) of the actin-binding protein palladin, which is overexpressed in invasive breast cancer cells, where it contributes to the assembly of matrix-degrading organelles called invadopodia. Palladin isoform 4 occupies a very unusual molecular niche, as it shuttles from the actin cytoskeleton to the nucleus, where it appears to \u201creport on\u201d the organizational state of the cytoskeleton and regulate patterns of gene expression. We are actively exploring the role of palladin isoform 4 in the stroma of pancreas tumors, where is appears to play a key role in establishing the phenotype of tumor-associated fibroblasts.<\/p>\n<h3>Awards and Honors<\/h3>\n<p>Dean&#8217;s Award for Excellence in Medical Education<\/p>\n<p><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/myncbi\/browse\/collection\/48371100\/?sort=date&amp;direction=ascending\" target=\"_self\" rel=\"noopener\"><img decoding=\"async\" class=\"image-left\" src=\"resolveuid\/b005c794c785ed6a07256685d63a57e9\/@@images\/image\/thumb\" \/><\/a><\/p>\n<h3>Affiliations<\/h3>\n<p><a class=\"external-link\" title=\"\" href=\"http:\/\/unclineberger.org\/\" target=\"_self\" rel=\"noopener\">Lineberger Comprehensive Cancer Center<\/a><br \/>\nAcademy of Educators<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Professor UNC-Chapel Hill Education and Training UCLA, PhD Areas of Interest My research program is focused on a fundamental property of cells, which is their ability to move. We want to understand how cells make the decision to either migrate or to remain stationary and adherent, and we are working to apply this knowledge to &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/\" aria-label=\"Read more about Carol Otey, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":9320,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4660","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Carol Otey, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Carol Otey, PhD - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Professor UNC-Chapel Hill Education and Training UCLA, PhD Areas of Interest My research program is focused on a fundamental property of cells, which is their ability to move. We want to understand how cells make the decision to either migrate or to remain stationary and adherent, and we are working to apply this knowledge to &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology and Physiology\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-08T18:03:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"120\" \/>\n\t<meta property=\"og:image:height\" content=\"160\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/\",\"name\":\"Carol Otey, PhD - Department of Cell Biology and Physiology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg\",\"datePublished\":\"2016-08-15T18:54:00+00:00\",\"dateModified\":\"2024-01-08T18:03:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg\",\"width\":120,\"height\":160},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Carol Otey, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\",\"name\":\"Department of Cell Biology and Physiology\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Carol Otey, PhD - Department of Cell Biology and Physiology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/","og_locale":"en_US","og_type":"article","og_title":"Carol Otey, PhD - Department of Cell Biology and Physiology","og_description":"Professor UNC-Chapel Hill Education and Training UCLA, PhD Areas of Interest My research program is focused on a fundamental property of cells, which is their ability to move. We want to understand how cells make the decision to either migrate or to remain stationary and adherent, and we are working to apply this knowledge to &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/","og_site_name":"Department of Cell Biology and Physiology","article_modified_time":"2024-01-08T18:03:48+00:00","og_image":[{"width":120,"height":160,"url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/","name":"Carol Otey, PhD - Department of Cell Biology and Physiology","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg","datePublished":"2016-08-15T18:54:00+00:00","dateModified":"2024-01-08T18:03:48+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/10\/Otey.jpeg","width":120,"height":160},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/carol-otey-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/cellbiophysio\/"},{"@type":"ListItem","position":2,"name":"Carol Otey, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/","name":"Department of Cell Biology and Physiology","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_upd_display_name":["Carol Otey, PhD"],"_upd_reverse_display_name":["Otey, Carol"],"_upd_last_name":["Otey"],"_upd_first_name":["Carol"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<p style=\"text-align: left\"><a class=\"email-link\" title=\"\" href=\"mailto:carol_otey@med.unc.edu\" target=\"_self\">Email<\/a><\/p>"],"_upd_no_link":["on"],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"carol_otey@med.unc.edu"}]],"_upd_phone":[],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/4660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/4660\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media\/9320"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media?parent=4660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}