{"id":4686,"date":"2016-08-15T14:54:00","date_gmt":"2016-08-15T18:54:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/james-bear-phd\/"},"modified":"2024-11-06T11:36:24","modified_gmt":"2024-11-06T16:36:24","slug":"james-bear-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/james-bear-phd\/","title":{"rendered":"James Bear, PhD"},"content":{"rendered":"

<\/p>\n

Professor
\nUNC-Chapel Hill<\/p>\n

\n

Education and Training<\/h3>\n

Davidson College, BS
\nEmory University, PhD
\nMIT, Postdoc<\/p>\n

Areas of Interest<\/h3>\n

The Bear lab studies actin cytoskeletal dynamics, cell motility and tumor invasion\/metastasis. We use a combination of modern molecular perturbations such as gene knockouts, over-expression and RNAi depletion to manipulate proteins involved in migration. In addition, we are studying how tumor cells mis-regulate their cell motility during invasion and metastasis. One of the main techniques utilized by the lab is live-cell microscopy. We use this technique across a range of length and time-scales to track proteins and protein complexes inside of cells, track the migration of cells and understand the consequences of migration for tissue architecture. We are also exploiting new micro-fabarication and microfluidic approaches to study the migration cells in response to gradients of various cues such as soluble growth factors (chemotaxis), substrate attached ECM proteins (haptotaxis) and gradients of mechanical stiffness (durotaxis).<\/p>\n

Awards and Honors:<\/h3>\n

1993: Phi Beta Kappa, Davidson College chapter
\n1997: ASCB Predoctoral Travel Award
\n1999-2000: Anna Fuller Molecular Oncology Fellow
\n2000: NIH NRSA Award
\n2001-04: Leukemia and Lymphoma Society Special Fellow
\n2004-06: V Scholar Award
\n2005-07: Melanoma Research Foundation Junior Faculty Award
\n2006-09: Sontag Foundation, Distinguished Scientist Award
\n2008-12: Research Scholar Award, American Cancer Society
\n2008-13: Jefferson-Pilot Award
\n2009-12: Faculty of 1000
\n2010: Ruth and Phillip Hettleman Prize for Artistic and Scholarly Achievement
\n2015: Omicron Delta Kappa, Honoris Causa, Davidson College circle<\/p>\n

\"\"<\/a><\/p>\n

Affiliations<\/h3>\n

UNC Lineberger Comprehensive Cancer Center<\/a>
\nDepartment of Pharmacology<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Professor UNC-Chapel Hill Education and Training Davidson College, BS Emory University, PhD MIT, Postdoc Areas of Interest The Bear lab studies actin cytoskeletal dynamics, cell motility and tumor invasion\/metastasis. We use a combination of modern molecular perturbations such as gene knockouts, over-expression and RNAi depletion to manipulate proteins involved in migration. In addition, we are … Read more<\/a><\/p>\n","protected":false},"featured_media":4687,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4686","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nJames Bear, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/james-bear-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"James Bear, PhD - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Professor UNC-Chapel Hill Education and Training Davidson College, BS Emory University, PhD MIT, Postdoc Areas of Interest The Bear lab studies actin cytoskeletal dynamics, cell motility and tumor invasion\/metastasis. 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