{"id":4692,"date":"2016-05-02T19:46:00","date_gmt":"2016-05-02T23:46:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/jimena-giudice-phd\/"},"modified":"2025-06-02T14:09:23","modified_gmt":"2025-06-02T18:09:23","slug":"jimena-giudice-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/jimena-giudice-phd\/","title":{"rendered":"Jimena Giudice, PhD"},"content":{"rendered":"

<\/p>\n

Associate Professor & CBP PhD Curriculum co-Director of Graduate Studies
\nUNC-Chapel Hill<\/p>\n

\n

Education and Training<\/h3>\n

3\/2001-5\/2005 | M.Ed. comparable<\/b>, Chemistry Education, University of Buenos Aires, Argentina
\n8\/2002-3\/2007 | M.Sc. comparable<\/b>, Chemistry, University of Buenos Aires, Argentina,
\n10\/2008-4\/2009 | EMBO short term visiting fellow<\/b>, Cell Biology, Max Planck Institute for Biophysical Chemistry, Germany
\n12\/2007-3\/2011 |<\/b> Ph.D.,<\/b> Biological Chemistry, University of Buenos Aires, Argentina
\n8\/2011-2\/2016 | Postdoctoral training<\/b>, Molecular and Developmental Biology, Baylor College of Medicine, Houston, TX
\n3\/2016 | Joined the Department<\/b><\/p>\n

Areas of Interest<\/h3>\n

Alternative splicing is a posttranscriptional mechanism that explains how individual genes can produce more than one transcript due to the inclusion or exclusion of specific regions originating multiple protein isoforms with diverse features. More than 90% of human genes undergo alternative splicing. This high prevalence raises the question of how developmental stage- and tissue-specific splicing influence protein function and how this regulation occurs.<\/p>\n

In our lab we are interested on how alternative splicing regulates the expression of trafficking and membrane dynamics proteins in normal development and diseases. A second angle of the lab is how alternative splicing impacts on the functions of these proteins and thus in internal cell architecture and physiology. We are initially focused on striated muscles (heart and skeletal muscle) because we found that trafficking and membrane dynamics genes are regulated by splicing specifically in these tissues and some of them also in brain. Misregulation of membrane trafficking proteins is one hallmark of muscle and brain disorders. In particular, striated muscle cells have contractility primordial functions that require a very precise formation and maintenance of internal architecture through membrane invagination and trafficking processes. Receptors and ion channels need to be correctly transported to these locations to exert their key functions. We are studying the crosstalk between alternative splicing and membrane trafficking and its contribution to the maturation and maintenance of the myocyte exquisite architecture and functions.<\/p>\n

Our lab utilizes a broad spectrum of approaches ranging from molecular biology, cell biology, and physiology techniques including animal models.<\/p>\n

Awards and Honors (selected)<\/em><\/h3>\n

2018-2020 Basil O’Connor Starter Scholar Award, March of Dimes Foundation
\n2018-2019 Pilot Research Grant $50K, NC TraCS
\n2017 Pilot Research Grant, Nutrition and Obesity Research Center, The University of North Carolina at Chapel Hill
\n2017 Junior Faculty Development Award, The University of North Carolina at Chapel Hill
\n2014 \u2013 2016 Postdoctoral Fellowship, American Heart Association
\n2012 \u2013 2016 Postdoctoral Fellowship, The Pew Charitable Trusts
\n2015 American Heart Association Spotlight award, 3rd<\/sup> Annual Cardiovascular Research Institute Symposium, Houston
\n2015 European Molecular Biology Organization (EMBO) travel award
\n2011 Gordon Research Conference travel award
\n2010 Carl Storm International Diversity Fellowship, Gordon Research Conference
\n2008 \u2013 2009 Short Term Fellowship, European Molecular Biology Organization (EMBO)
\n2008 \u2013 2009 Short Term Fellowship, German Academic Exchange Service (DAAD), gratefully declined
\n2008 \u2013 2011 Predoctoral Fellowship Type I, National Scientific and Technical Research Council (CONICET), Argentina<\/p>\n

\"\"<\/a><\/p>\n

Affiliations<\/h3>\n

Department of Cell Biology and Physiology
\nMcAllister Heart Institute
\nCurriculum in Cell Biology and Physiology
\nCurriculum in Genetics and Molecular Biology<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Associate Professor & CBP PhD Curriculum co-Director of Graduate Studies UNC-Chapel Hill Education and Training 3\/2001-5\/2005 | M.Ed. comparable, Chemistry Education, University of Buenos Aires, Argentina 8\/2002-3\/2007 | M.Sc. comparable, Chemistry, University of Buenos Aires, Argentina, 10\/2008-4\/2009 | EMBO short term visiting fellow, Cell Biology, Max Planck Institute for Biophysical Chemistry, Germany 12\/2007-3\/2011 | Ph.D., … Read more<\/a><\/p>\n","protected":false},"featured_media":12656,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4692","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nJimena Giudice, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/jimena-giudice-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jimena Giudice, PhD - 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