{"id":4712,"date":"2016-08-15T14:57:00","date_gmt":"2016-08-15T18:57:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/"},"modified":"2020-10-06T13:27:49","modified_gmt":"2020-10-06T17:27:49","slug":"martina-gentzsch-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/","title":{"rendered":"Martina Gentzsch, PhD"},"content":{"rendered":"<p><!-- title_affiliation --><\/p>\n<p>Associate Professor<br \/>\nUNC-Chapel Hill<\/p>\n<div>\n<h3>Education and Training<\/h3>\n<p>1997: <b>Ph.D.<\/b> Cell Biology: Glycoprotein Processing<i><br \/>\n<\/i>University of Regensburg, Germany<i><\/i><\/p>\n<p>1993: <b>M.S.<\/b> Cell Biology, Biochemistry, Genetics, Organic Chemistry<br \/>\nUniversity of Regensburg, Germany <i><\/i><\/p>\n<p>1991: <b>B.S.<\/b> Cell Biology, Genetics, Physics, Chemistry<br \/>\nUniversity of Regensburg, Germany<\/p>\n<h3>Areas of Interest<\/h3>\n<p>My research aims to understand the cellular and molecular mechanisms involved in the intracellular trafficking and regulation of ion channels that play critical roles in airway diseases. One of my major interests is to explore potential targets that are of clinical importance for cystic fibrosis (CF) therapy such as restoration of normal ion channel function in CF patients. The epithelial anion channel CF transmembrane conductance regulator (CFTR) is mutated in CF patients. My laboratory has developed a variety of biochemical, electrophysiological and cell biological state-of-the-art pre-clinical assays to investigate the efficacy of novel therapeutic approaches to rescue CFTR in relevant differentiated model systems including nasal, bronchial and intestinal planar (2D) and organoid (3D) cultures. Our present studies assess: 1) the diverse roles of CFTR in different organs, 2) differences in rescue and stability of CFTR in different tissues, and 3) mechanistic details on how environmental factors affect CFTR function and rescue. We are applying the knowledge obtained from these studies towards the design of bio-assays that predict optimal personalized treatment plans for each individual patient.<\/p>\n<h3>Awards and Honors<\/h3>\n<p>2015: Adolf Windorfer Prize for outstanding research in Cystic Fibrosis<\/p>\n<p>2014: Marsico Scholar Award<\/p>\n<p>2010: Profiled Author of the Paper of the Week, Journal of Biological Chemistry<\/p>\n<p>2009: UNC Cystic Fibrosis Center Star Heel Award<\/p>\n<p>2003: Young Investigator Award, 4th FEBS Advanced Lecture Course on ATP-Binding Cassette Proteins, Gosau, Austria<\/p>\n<p>1998-2000: Research Stipend from the German Research Association (DFG)<\/p>\n<p>1997: Culture Award for Ph.D. Thesis, E.ON group (Europe\u2019s largest energy provider)<\/p>\n<p>1997: Ph.D. Honors graduation: <i>SUMMA CUM LAUDE<\/i><\/p>\n<p><i><\/i><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Gentzsch%20M%5BAuthor%5D&amp;cmd=DetailsSearch\" target=\"_self\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"image-inline alignnone\" src=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/07\/ncbi.png\" alt=\"\" width=\"164\" height=\"82\" \/><\/a><\/p>\n<h3>Affiliations<\/h3>\n<p>Marsico Lung Institute and Cystic Fibrosis Research Center<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Associate Professor UNC-Chapel Hill Education and Training 1997: Ph.D. Cell Biology: Glycoprotein Processing University of Regensburg, Germany 1993: M.S. Cell Biology, Biochemistry, Genetics, Organic Chemistry University of Regensburg, Germany 1991: B.S. Cell Biology, Genetics, Physics, Chemistry University of Regensburg, Germany Areas of Interest My research aims to understand the cellular and molecular mechanisms involved in &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/\" aria-label=\"Read more about Martina Gentzsch, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":9774,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4712","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Martina Gentzsch, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Martina Gentzsch, PhD - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Associate Professor UNC-Chapel Hill Education and Training 1997: Ph.D. Cell Biology: Glycoprotein Processing University of Regensburg, Germany 1993: M.S. Cell Biology, Biochemistry, Genetics, Organic Chemistry University of Regensburg, Germany 1991: B.S. Cell Biology, Genetics, Physics, Chemistry University of Regensburg, Germany Areas of Interest My research aims to understand the cellular and molecular mechanisms involved in &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology and Physiology\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-06T17:27:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"2409\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/\",\"name\":\"Martina Gentzsch, PhD - Department of Cell Biology and Physiology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg\",\"datePublished\":\"2016-08-15T18:57:00+00:00\",\"dateModified\":\"2020-10-06T17:27:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg\",\"width\":2560,\"height\":2409,\"caption\":\"Gentzsch, Martina\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Martina Gentzsch, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\",\"name\":\"Department of Cell Biology and Physiology\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Martina Gentzsch, PhD - Department of Cell Biology and Physiology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/","og_locale":"en_US","og_type":"article","og_title":"Martina Gentzsch, PhD - Department of Cell Biology and Physiology","og_description":"Associate Professor UNC-Chapel Hill Education and Training 1997: Ph.D. Cell Biology: Glycoprotein Processing University of Regensburg, Germany 1993: M.S. Cell Biology, Biochemistry, Genetics, Organic Chemistry University of Regensburg, Germany 1991: B.S. Cell Biology, Genetics, Physics, Chemistry University of Regensburg, Germany Areas of Interest My research aims to understand the cellular and molecular mechanisms involved in &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/","og_site_name":"Department of Cell Biology and Physiology","article_modified_time":"2020-10-06T17:27:49+00:00","og_image":[{"width":2560,"height":2409,"url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/","name":"Martina Gentzsch, PhD - Department of Cell Biology and Physiology","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg","datePublished":"2016-08-15T18:57:00+00:00","dateModified":"2020-10-06T17:27:49+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg","contentUrl":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/1-scaled.jpg","width":2560,"height":2409,"caption":"Gentzsch, Martina"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/martina-gentzsch-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/cellbiophysio\/"},{"@type":"ListItem","position":2,"name":"Martina Gentzsch, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/cellbiophysio\/#website","url":"https:\/\/www.med.unc.edu\/cellbiophysio\/","name":"Department of Cell Biology and Physiology","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_upd_display_name":["Martina Gentzsch, PhD"],"_upd_reverse_display_name":["Gentzsch, Martina"],"_upd_last_name":["Gentzsch"],"_upd_first_name":["Martina"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<p style=\"text-align: left\"><strong>Associate Professor<\/strong><\/p>\r\n<p style=\"text-align: left\"><span style=\"line-height: 1.5em\"><strong>Office:<\/strong> \u00a01121 Marsico<\/span><\/p>\r\n<p style=\"text-align: left\"><span style=\"line-height: 1.5em\"><strong>Phone:<\/strong> \u00a0919-966-7058\r\n<\/span><\/p>\r\n<p style=\"text-align: left\"><span style=\"line-height: 1.5em\"><a class=\"email-link\" title=\"\" href=\"mailto:gentzsch@med.unc.edu\" target=\"_self\">Email\u00a0<\/a><\/span><\/p>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"martina_gentzsch@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-966-7058","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"1121 Marsico Hall","address-2":"Campus Box 7545","campus-box":"","city":"Chapel Hill","state":"NC","zip":"27599-7545"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/4712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/directory\/4712\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media\/9774"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-json\/wp\/v2\/media?parent=4712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}