{"id":4747,"date":"2016-08-15T14:54:00","date_gmt":"2016-08-15T18:54:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/"},"modified":"2024-11-06T11:49:04","modified_gmt":"2024-11-06T16:49:04","slug":"stephanie-gupton-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/","title":{"rendered":"Stephanie Gupton, PhD"},"content":{"rendered":"<p><!-- title_affiliation --><\/p>\n<p>Professor<br \/>\nUNC-Chapel Hill<\/p>\n<div>\n<h3>Education and Training<\/h3>\n<p>North Carolina State University, BS, 2001<br \/>\nScripps Research Institute, PhD, 2006<br \/>\nMassachusetts Institute for Technology, Postdoctoral, 2006-2011<\/p>\n<h3>Areas of Interest<\/h3>\n<p>Integrity in axon guidance and axon branching is required for the functional organization of the nervous system. Both axon guidance and axon branching employ the same fundamental cellular machinery: a dynamic cytoskeleton produces the force to initiate axonal plasma membrane protrusion, while vesicle trafficking supplies phospholipids and membrane proteins to the dramatically expanding axonal plasma membrane. Extracellular guidance cues, such as netrin, likely coordinate cytoskeletal dynamics and vesicle trafficking to elicit specific neuronal responses. In my lab we are investigating the role of two neuronally-expressed ubiquitin ligases, TRIM9 and TRIM67, in netrin-dependent axon guidance and branching. We utilize a variety techniques including high resolution live cell microscopy, gene disruption, mouse models, microfluidics and biochemistry to understand the complex coordination of cytoskeletal dynamics and membrane trafficking driving neuronal shape change and growth cone motility in primary neurons and in the developing vertebrate mammalian nervous system.<\/p>\n<h3>Awards and Honors<\/h3>\n<p>MIT Koch Institute Image Award, 2011<br \/>\nMerck\/MIT senior postdoctoral fellowship, 2010-2011<br \/>\nFellow, Jane Coffin Childs Memorial Fund for Medical Research, 2006-2009<br \/>\nMerton R. Bernfield Memorial Award from the American Society for Cell Biology, 2005<br \/>\nHoward Hughes Medical Institute Predoctoral Fellowship, 2001-2006<br \/>\nBachelor of Science, Magna cum laude, valedictorian, North Carolina State University, 2001<\/p>\n<p><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/myncbi\/browse\/collection\/46436024\/?sort=date&amp;direction=descending\" target=\"_self\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"image-inline alignnone\" src=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/07\/ncbi.png\" alt=\"\" width=\"164\" height=\"82\" \/><\/a><\/p>\n<h3>Affiliations<\/h3>\n<p>Cell Biology and Physiology Curriculum<br \/>\nAmerican Society of Cell Biology, 2000-present<br \/>\nSociety for Neuroscience, 2013-present<br \/>\nUNC Lineberger Comprehensive Cancer Center, 2011-present<br \/>\nUNC Neuroscience Center, 2011-present<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Professor UNC-Chapel Hill Education and Training North Carolina State University, BS, 2001 Scripps Research Institute, PhD, 2006 Massachusetts Institute for Technology, Postdoctoral, 2006-2011 Areas of Interest Integrity in axon guidance and axon branching is required for the functional organization of the nervous system. Both axon guidance and axon branching employ the same fundamental cellular machinery: &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/\" aria-label=\"Read more about Stephanie Gupton, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":9775,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4747","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Stephanie Gupton, PhD - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stephanie Gupton, PhD - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Professor UNC-Chapel Hill Education and Training North Carolina State University, BS, 2001 Scripps Research Institute, PhD, 2006 Massachusetts Institute for Technology, Postdoctoral, 2006-2011 Areas of Interest Integrity in axon guidance and axon branching is required for the functional organization of the nervous system. Both axon guidance and axon branching employ the same fundamental cellular machinery: &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology and Physiology\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-06T16:49:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/9B7A0265-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/\",\"name\":\"Stephanie Gupton, PhD - Department of Cell Biology and Physiology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/9B7A0265-scaled.jpg\",\"datePublished\":\"2016-08-15T18:54:00+00:00\",\"dateModified\":\"2024-11-06T16:49:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/9B7A0265-scaled.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2019\/01\/9B7A0265-scaled.jpg\",\"width\":2560,\"height\":1707,\"caption\":\"Gupton, Stephanie\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Stephanie Gupton, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/\",\"name\":\"Department of Cell Biology and Physiology\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Stephanie Gupton, PhD - Department of Cell Biology and Physiology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/stephanie-gupton-phd\/","og_locale":"en_US","og_type":"article","og_title":"Stephanie Gupton, PhD - Department of Cell Biology and Physiology","og_description":"Professor UNC-Chapel Hill Education and Training North Carolina State University, BS, 2001 Scripps Research Institute, PhD, 2006 Massachusetts Institute for Technology, Postdoctoral, 2006-2011 Areas of Interest Integrity in axon guidance and axon branching is required for the functional organization of the nervous system. 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