{"id":13404,"date":"2024-07-08T23:09:12","date_gmt":"2024-07-09T03:09:12","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/?p=13404"},"modified":"2024-07-08T23:17:33","modified_gmt":"2024-07-09T03:17:33","slug":"ben-philpot-potential-treatment-angelman-syndrome","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/ben-philpot-potential-treatment-angelman-syndrome\/","title":{"rendered":"Researchers in the lab of Dr. Ben Philpot Identify Potential Treatment for Angelman Syndrome"},"content":{"rendered":"<p>Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities. Though there isn\u2019t a cure for the condition, new research at the UNC School of Medicine is setting the stage for one.<\/p>\n<p><strong>Ben Philpot<\/strong>, PhD, the Kenan Distinguished Professor of Cell Biology and Physiology at the UNC School of Medicine and associate director of the UNC Neuroscience Center, and his lab have identified a small molecule that could be safe, non-invasively delivered, and capable of \u201cturning on\u201d the dormant paternally-inherited UBE3A gene copy brain-wide, which would lead to proper protein and cell function, amounting to a kind of gene therapy for individuals with Angelman syndrome.<\/p>\n<p><strong>Hanna Vihma<\/strong>, PhD, a postdoctoral research fellow in the Philpot lab and first author on the study, and colleagues screened more than 2,800 small molecules from a Pfizer chemogenetic library to determine if one could potently turn on paternal UBE3A in mouse models with Angelman syndrome.<\/p>\n<p>\u201c<em>This compound we identified has shown to have excellent uptake in the developing brains of animal models<\/em>,\u201d said Philpot, who is a leading expert on Angelman syndrome. \u201c<em>We still have a lot of work to do before we could start a clinical trial, but this small molecule provides an excellent starting point for developing a safe and effective treatment for Angelman syndrome<\/em>.\u201d<\/p>\n<p>These results, which were published in <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-49788-8\">Nature Communications<\/a>, mark a major milestone in the field, according to <strong>Mark Zylka<\/strong>, PhD, the W.R. Kenan Jr. Distinguished Professor of Cell Biology and Physiology at the UNC School of Medicine and Director of the UNC Neuroscience Center. No other small molecule compound has yet to show such promise for Angelman, he added.<\/p>\n<p>Check out the full story at the UNC Health and UNC School of Medicine <a href=\"http:\/\/news.unchealthcare.org\/2024\/07\/researchers-identify-potential-treatment-for-angelman-syndrome\/\">Newsroom<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities. Though there isn\u2019t a cure for the condition, new research at the UNC School of Medicine is setting the stage for one. Ben Philpot, PhD, the Kenan Distinguished &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/ben-philpot-potential-treatment-angelman-syndrome\/\" aria-label=\"Read more about Researchers in the lab of Dr. Ben Philpot Identify Potential Treatment for Angelman Syndrome\">Read more<\/a><\/p>\n","protected":false},"author":4675,"featured_media":13405,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[51],"tags":[67,66],"featured-item":[],"class_list":["post-13404","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-article","tag-angelman","tag-philpot","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers in the lab of Dr. Ben Philpot Identify Potential Treatment for Angelman Syndrome - Department of Cell Biology and Physiology<\/title>\n<meta name=\"description\" content=\"philpot angelman syndrome treatment\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/ben-philpot-potential-treatment-angelman-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers in the lab of Dr. Ben Philpot Identify Potential Treatment for Angelman Syndrome - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"philpot angelman syndrome treatment\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/ben-philpot-potential-treatment-angelman-syndrome\/\" \/>\n<meta property=\"og:site_name\" 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