{"id":14052,"date":"2024-11-12T15:40:13","date_gmt":"2024-11-12T20:40:13","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/?p=14052"},"modified":"2024-11-12T15:40:13","modified_gmt":"2024-11-12T20:40:13","slug":"the-black-hole-deep-inside-the-liver","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/the-black-hole-deep-inside-the-liver\/","title":{"rendered":"The black hole deep inside the liver"},"content":{"rendered":"

An image from Berfin Azizoglu<\/a>\u2019s team showing the vascular organization underlying blood drainage from the liver wins the School of Medicine’s\u00a02024 Art in Science Competition!<\/em><\/p>\n

\n
\"A
Image credit: Aashita Rajput, Jack Bennett, and Berfin Azizoglu<\/figcaption><\/figure>\n

A snapshot of this image’s research significance<\/h1>\n

What does this image show?<\/strong><\/h2>\n
\n

This image shows the three-dimensional vascular organization of the adult mouse liver. The liver has two lobes, each comprised of thousands of hexagonally shaped lobules containing liver cells. This image zooms into a single liver lobule. Blood enters the liver lobule through peripheral vessels, shown in a teal-like color at the edge of the image. It travels through irregularly shaped liver capillaries called sinusoids, shown in yellow, and tiny blood vessels called venules, shown in magenta. Finally, it drains through a central vein, seen in this image as a black hole in the lobule center. Blood drainage from the liver is essential for removing metabolic end products and detoxified substances from the body.<\/p>\n<\/div>\n

\n

How does this image help advance the research of the Azizoglu\u00a0lab group?<\/b><\/span><\/h2>\n<\/div>\n
\n
\n

Berfin Azizoglu\u2019s research team studies how the mammalian liver regenerates. They visualize the normal mouse liver at the organ scale with cellular resolution and compare it to injured livers to assess how the organization of the liver, its lobules, and vasculature change over time following injury and during recovery. Identifying these alterations sheds light on the mechanisms used by the liver to restore physiology and function in response to damage.<\/p>\n<\/div>\n

How was this image taken?<\/b><\/span><\/h2>\n<\/div>\n
\n

This maximum projection image was taken as a z-stack using a Leica SP8 confocal microscope at the Department of Cell Biology and Physiology.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

An image from Berfin Azizoglu\u2019s team showing the vascular organization underlying blood drainage from the liver wins the School of Medicine’s\u00a02024 Art in Science Competition! A snapshot of this image’s research significance What does this image show? This image shows the three-dimensional vascular organization of the adult mouse liver. The liver has two lobes, each … Read more<\/a><\/p>\n","protected":false},"author":77299,"featured_media":14053,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[52,2],"tags":[96,77,97],"featured-item":[],"class_list":["post-14052","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-news","category-news","tag-liver","tag-sciart","tag-vasculature","odd"],"acf":[],"yoast_head":"\nThe black hole deep inside the liver - Department of Cell Biology and Physiology<\/title>\n<meta name=\"description\" content=\"An image of the vascular organization underlying blood drainage from the liver wins the School of Medicine's\u00a02024 Art in Science Competition.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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