{"id":4019,"date":"2009-05-15T14:00:00","date_gmt":"2009-05-15T18:00:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/"},"modified":"2018-10-17T13:38:35","modified_gmt":"2018-10-17T17:38:35","slug":"philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/","title":{"rendered":"Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome"},"content":{"rendered":"<div>\n<h3>Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome<\/h3>\n<table style=\"width: 114px;height: 126px\" border=\"0\" cellspacing=\"1\" cellpadding=\"1\" align=\"left\">\n<tbody>\n<tr>\n<td><img loading=\"lazy\" decoding=\"async\" style=\"border: 1px solid #666666\" title=\"fac_philpot_09\" src=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/06\/image.x-ms-bmp\" alt=\"fac_philpot_09\" width=\"108\" height=\"150\" class=\"size-medium wp-image-3272\"><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center\"><span class=\"discreet\">Philpot<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>5\/10\/2009 \u2013 Researchers in <a href=\"\/cellbiophysio\/faculty-old\/philpot\">Ben Philpot\u2019s lab<\/a> have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome, an autism spectrum disorder. In a study published in the journal Nature Neuroscience, they found that the gene, UBE3A, is needed so that neurons in the brain can adjust their connections with other neurons for storing sensory information. They also made the exciting discovery that this brain plasticity could be restored in Angelman model mice by sensory deprivation. This finding suggests that this latent ability to express plasticity in Angelman syndrome patients might be tapped into through future pharmaceutical or behavioral treatments to restore lost cognitive functions.<\/p>\n<p><a href=\"http:\/\/www.nature.com\/neuro\/journal\/vaop\/ncurrent\/abs\/nn.2327.html\">link to full paper: <\/a><a href=\"http:\/\/www.nature.com\/neuro\/journal\/vaop\/ncurrent\/abs\/nn.2327.html\"> http:\/\/www.nature.com\/neuro\/journal\/vaop\/ncurrent\/abs\/nn.2327.html<\/a><\/p>\n<p>UNC School of Medicine press release &gt;&gt;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome Philpot 5\/10\/2009 \u2013 Researchers in Ben Philpot\u2019s lab have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome, an autism spectrum disorder. In a study published in the journal &hellip; <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/\" aria-label=\"Read more about Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome\">Read more<\/a><\/p>\n","protected":false},"author":80868,"featured_media":3306,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[5],"featured-item":[],"class_list":["post-4019","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-philpot-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome - Department of Cell Biology and Physiology\" \/>\n<meta property=\"og:description\" content=\"Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome Philpot 5\/10\/2009 \u2013 Researchers in Ben Philpot\u2019s lab have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome, an autism spectrum disorder. In a study published in the journal &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology and Physiology\" \/>\n<meta property=\"article:published_time\" content=\"2009-05-15T18:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-17T17:38:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/06\/image.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"143\" \/>\n\t<meta property=\"og:image:height\" content=\"187\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Nathaniel Bailey\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nathaniel Bailey\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/\"},\"author\":{\"name\":\"Nathaniel Bailey\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\"},\"headline\":\"Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome\",\"datePublished\":\"2009-05-15T18:00:00+00:00\",\"dateModified\":\"2018-10-17T17:38:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/\"},\"wordCount\":169,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/wp-content\/uploads\/sites\/734\/2018\/06\/image.jpeg\",\"keywords\":[\"Philpot news\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/\",\"url\":\"https:\/\/www.med.unc.edu\/cellbiophysio\/philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome\/\",\"name\":\"Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome - 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