{"id":4166,"date":"2012-06-22T17:19:26","date_gmt":"2012-06-22T21:19:26","guid":{"rendered":"https:\/\/www.med.unc.edu\/cellbiophysio\/the-dudley-lab-publishes-a-manuscript-showing-how-fat-cells-fuel-tumor-growth-and-angiogenesis-by-contributing-to-inflammation-and-acting-as-a-depot-for-tumor-associatedby-contributing-to-inflammation\/"},"modified":"2018-10-17T13:41:48","modified_gmt":"2018-10-17T17:41:48","slug":"the-dudley-lab-publishes-a-manuscript-showing-how-fat-cells-fuel-tumor-growth-and-angiogenesis-by-contributing-to-inflammation-and-acting-as-a-depot-for-tumor-associatedby-contributing-to-inflammation","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/cellbiophysio\/the-dudley-lab-publishes-a-manuscript-showing-how-fat-cells-fuel-tumor-growth-and-angiogenesis-by-contributing-to-inflammation-and-acting-as-a-depot-for-tumor-associatedby-contributing-to-inflammation\/","title":{"rendered":"The Dudley lab publication shows how fat cells fuel tumor growth and angiogenesis by contributing to inflammation and acting as a depot for tumor-associated"},"content":{"rendered":"
\n

June 2012 \u2013 Assistant professor Drew Dudley and colleagues publish a study in the journal Angiogenesis<\/p>\n

\n
Drew Dudley, PhD<\/figcaption><\/figure>\n<\/div>\n
\n

June 2012 \u2013 Solid tumors resemble dysfunctional \u201corgans\u201d of malignant cells and supporting stromal cells including vascular cells, immune cells and fibroblasts. The Dudley lab has published a manuscript in the journal Angiogenesis<\/i> showing how adipose tissue (fat cells) fuels tumor growth and angiogenesis by contributing to inflammation and acting as a depot for tumor-associated macrophages.<\/p>\n

These studies are particularly relevant for breast cancers which grow within a \u201cnest\u201d of adipose tissue and metastasis to lymph nodes which are typically shrouded by adipocytes. Moreover, this is the first study to show how macrophages from adipose tissue at the periphery of growing tumors are specifically polarized in a way that exacerbates inflammation and contributes to neovascularization.<\/p>\n

Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis. 2012 May 22 [Epub ahead of print].<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

June 2012 – Assistant professor Drew Dudley and colleagues publish a study in the journal Angiogenesis<\/p>\n","protected":false},"author":80868,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"featured-item":[],"class_list":["post-4166","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"\nThe Dudley lab publication shows how fat cells fuel tumor growth and angiogenesis by contributing to inflammation and acting as a depot for tumor-associated - Department of Cell Biology and Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/the-dudley-lab-publishes-a-manuscript-showing-how-fat-cells-fuel-tumor-growth-and-angiogenesis-by-contributing-to-inflammation-and-acting-as-a-depot-for-tumor-associatedby-contributing-to-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Dudley lab publication shows how fat cells fuel tumor growth and angiogenesis by contributing to inflammation and acting as a depot for tumor-associated - 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