{"id":16907,"date":"2023-12-11T14:19:08","date_gmt":"2023-12-11T19:19:08","guid":{"rendered":"https:\/\/www.med.unc.edu\/cfar\/?page_id=16907"},"modified":"2025-09-12T14:50:19","modified_gmt":"2025-09-12T18:50:19","slug":"biostatistics-resources","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cfar\/resources\/biostatistics-resources\/","title":{"rendered":"Biostatistics Resources"},"content":{"rendered":"<h2>Tools<\/h2>\n<p><a href=\"https:\/\/cran.r-project.org\/web\/packages\/SLDAssay\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">R package for Serial Limiting Dilution Assay Statistics (SLDAssay)<\/a><\/p>\n<p><a href=\"http:\/\/www.scharp.org\/tools\/RLDwebCalc\/RLD.php\" target=\"_blank\" rel=\"noopener noreferrer\">Power Calculator for Repeated Low-Dose Challenge Studies<\/a><\/p>\n<p><a href=\"https:\/\/cran.r-project.org\/web\/packages\/wmwpow\/index.html\">R Package for Rank-Sum Power Calculation (wmwpow)<\/a><\/p>\n<h2>Brief Statistical Safety Checklist<\/h2>\n<h3>Purpose:<\/h3>\n<p>This checklist is designed to help review draft manuscripts, statistical reports, or analysis plans<\/p>\n<h3>Methods:<\/h3>\n<ul>\n<li>Objective \/ hypotheses of the study are clearly stated<\/li>\n<li>Endpoints are defined, declare endpoints as primary, secondary, and exploratory as appropriate<\/li>\n<li>Exposures and covariates are defined<\/li>\n<li>Sample size calculation is explained (if applicable)<\/li>\n<li>If applicable, randomization and blinding process are explained<\/li>\n<li>If applicable, interim stopping guidelines are described<\/li>\n<li>All statistical methods are described (with references as needed)<\/li>\n<li>Methodological assumptions were reasonably met<\/li>\n<li>Reasonable considerations were made for:\n<ul>\n<li>missing data or attrition (e.g. loss to follow-up)<\/li>\n<li>multiple testing or multiple comparisons<\/li>\n<li>correlation among observations (e.g. longitudinal or clustered data)<\/li>\n<li>small sample sizes (e.g. n&lt;30)<\/li>\n<\/ul>\n<\/li>\n<li>Statistical software and version used are stated (e.g. SAS version 9.3, Cary, North Carolina)<\/li>\n<li>Statistical type I error probability is declared (e.g. two-sided alpha of 0.05)<\/li>\n<li>Clinical trials: trial registration ID included (<a href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/a>)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Results (including text, tables, figures):<\/h3>\n<ul>\n<li>Number of decimal places reported appropriately reflects measurement precision<\/li>\n<li>Summaries of variability\/spread are provided (e.g. SD, IQR)<\/li>\n<li>Sample sizes are provided (n=) and missing data are declared when applicable<\/li>\n<li>Each p-value is accompanied by a graphical display of data and descriptive statistics. Estimation with precision quantified (e.g., 95% confidence interval) is preferred.<\/li>\n<li>If reporting p-values, report specific p-values (p=0.027), rather than p&lt;0.05<\/li>\n<li>Use of the word <i>significant<\/i> should be avoided<\/li>\n<li>Figures are clearly explained by a legend and all axes and symbols are appropriately labeled<\/li>\n<li>Distorted effect sizes (e.g. by truncation of y-axis) are clearly labeled and justified<\/li>\n<li>Units of measurement are stated<\/li>\n<\/ul>\n<h3>Discussion:<\/h3>\n<ul>\n<li>Discussion conclusions are in agreement with results<\/li>\n<li>Limitations of the study design or analytic approach are appropriately stated<\/li>\n<\/ul>\n<p>For more guidance, refer to standard reporting guidelines (e.g. CONSORT, STROBE, PRISMA, STARD) and the ASA p-value statement (and published updates thereof)<\/p>\n<p>This list was compiled with reference to \u2018Instructions for Authors\u2019 at \u00a0<i>JAMA, Annals of Internal Medicine, Nature,\u00a0<\/i>and\u00a0<i>Science Magazine.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tools R package for Serial Limiting Dilution Assay Statistics (SLDAssay) Power Calculator for Repeated Low-Dose Challenge Studies R Package for Rank-Sum Power Calculation (wmwpow) Brief Statistical Safety Checklist Purpose: This checklist is designed to help review draft manuscripts, statistical reports, or analysis plans Methods: Objective \/ hypotheses of the study are clearly stated Endpoints are &hellip; <a href=\"https:\/\/www.med.unc.edu\/cfar\/resources\/biostatistics-resources\/\" aria-label=\"Read more about Biostatistics Resources\">Read more<\/a><\/p>\n","protected":false},"author":79967,"featured_media":0,"parent":16651,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-16907","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/pages\/16907","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/users\/79967"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/comments?post=16907"}],"version-history":[{"count":2,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/pages\/16907\/revisions"}],"predecessor-version":[{"id":18675,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/pages\/16907\/revisions\/18675"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/pages\/16651"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/media?parent=16907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}