{"id":18562,"date":"2025-07-03T16:01:33","date_gmt":"2025-07-03T20:01:33","guid":{"rendered":"https:\/\/www.med.unc.edu\/cfar\/?p=18562"},"modified":"2025-07-03T16:23:02","modified_gmt":"2025-07-03T20:23:02","slug":"undetected-the-lung-cancer-epidemic-in-hiv-communities","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/cfar\/2025\/07\/undetected-the-lung-cancer-epidemic-in-hiv-communities\/","title":{"rendered":"Hidden in Plain Sight: The Lung Cancer Crisis Facing HIV Communities"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-18564\" src=\"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Group-Photo-Screening-Gap.png-copy-283x300.jpg\" alt=\"\" width=\"540\" height=\"573\" srcset=\"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Group-Photo-Screening-Gap.png-copy-283x300.jpg 283w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Group-Photo-Screening-Gap.png-copy-964x1024.jpg 964w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Group-Photo-Screening-Gap.png-copy-768x815.jpg 768w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Group-Photo-Screening-Gap.png-copy-600x637.jpg 600w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Group-Photo-Screening-Gap.png-copy.jpg 1310w\" sizes=\"auto, (max-width: 540px) 100vw, 540px\" \/><\/p>\n<p><span data-contrast=\"none\">As people living with HIV (PLWH) benefit from longer life expectancy due to antiretroviral therapy, a new threat is emerging\u2014<\/span><span data-contrast=\"none\">lung cancer<\/span><span data-contrast=\"none\">\u00a0is now one of the leading causes of death in this population. The reasons are complex: PLWH are twice as likely to smoke, face higher cancer risk at younger ages, and experience immunosuppression and chronic inflammation that compound risk.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:322,&quot;335559739&quot;:322}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Addressing a Silent Crisis<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Dr. Subhashini Sellers, MD, MSCR, assistant professor in pulmonary critical care at UNC, led a study supported by a CFAR Developmental Award examining\u00a0lung cancer screening eligibility and uptake\u00a0among PLWH at UNC Health. She presented the findings at a recent UNC Friday Conference.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Screening Saves Lives\u2014But Access Falls Short<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The\u00a0U.S. Preventive Services Task Force (USPSTF)\u00a0recommends lung cancer screening using low-dose CT scans for adults aged 50\u201380 with a significant smoking history. In 2021, these criteria expanded to include individuals with at least a 20-pack-year smoking history. Yet\u00a0PLWH were not considered\u00a0in the original models or guidelines.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Currently,\u00a0only 3\u20135%\u00a0of eligible individuals in the general population are being screened\u2014and among PLWH, adherence is even lower.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Key Findings from UNC Health<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Dr. Sellers\u2019s team reviewed health data from\u00a07,000 PLWH receiving care at UNC Health, analyzing demographics, HIV markers, substance use history, and lung cancer screening data from 2014\u20132023. Key findings included:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"45\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">In 2014,\u00a0only 9%\u00a0of eligible patients were screened.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"45\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">By 2023, screening rates improved to\u00a029%, but large gaps remain.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"45\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Black and Hispanic patients, uninsured individuals, and those with low CD4 counts or higher viral loads were\u00a0less likely to meet screening eligibility or be screened.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><b><span data-contrast=\"none\">What\u2019s Next?<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Future analysis will examine\u00a0adherence patterns, such as the time from eligibility to first CT scan and annual follow-ups. The research aims to inform\u00a0tailored interventions\u00a0for PLWH, including:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"46\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Patient outreach and navigation<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"46\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Health system optimization<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"46\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Reducing barriers specific to HIV care and stigma<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><b><span data-contrast=\"none\">A Life Saved<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335551550&quot;:0,&quot;335551620&quot;:0,&quot;335559738&quot;:299,&quot;335559739&quot;:299}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Dr. David Margolis, the CFAR Co-Director, shared<\/span><span data-contrast=\"none\"> a powerful story: one of his HIV patients was identified for screening, underwent a CT scan, and was diagnosed with early-stage lung cancer. The patient received life-saving surgery. To read more about Dr. Sellers\u2019s study on UNC&#8217;s Institute for Global Health&#8217;s website click <a href=\"https:\/\/globalhealth.unc.edu\/2025\/07\/undetected-the-lung-cancer-epidemic-in-hiv-communities\/?utm_medium=email&amp;_hsenc=p2ANqtz-9e2lQzcDq1y0vjSK8SMJErJwymdqn1Iz6hETXXrx8NyjPJfsAWGiW6-2kb5LEovlPTI2uDu4hGi9U1lkp-6PyJCz2JbC4rZ7K7uZNrgej-JepeL-E&amp;_hsmi=369518796&amp;utm_content=369518796&amp;utm_source=hs_email\">here<\/a>.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As people living with HIV (PLWH) benefit from longer life expectancy due to antiretroviral therapy, a new threat is emerging\u2014lung cancer\u00a0is now one of the leading causes of death in this population. The reasons are complex: PLWH are twice as likely to smoke, face higher cancer risk at younger ages, and experience immunosuppression and chronic &hellip; <a href=\"https:\/\/www.med.unc.edu\/cfar\/2025\/07\/undetected-the-lung-cancer-epidemic-in-hiv-communities\/\" aria-label=\"Read more about Hidden in Plain Sight: The Lung Cancer Crisis Facing HIV Communities\">Read more<\/a><\/p>\n","protected":false},"author":120087,"featured_media":18565,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-18562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/3087x3859-scaled.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/3087x3859-240x300.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/3087x3859-768x960.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/3087x3859-819x1024.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/3087x3859-150x150.jpg","featured_image_alt":"","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/cfar\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts\/18562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/users\/120087"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/comments?post=18562"}],"version-history":[{"count":5,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts\/18562\/revisions"}],"predecessor-version":[{"id":18571,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts\/18562\/revisions\/18571"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/media\/18565"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/media?parent=18562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/categories?post=18562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/tags?post=18562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}