{"id":18586,"date":"2025-07-17T08:53:09","date_gmt":"2025-07-17T12:53:09","guid":{"rendered":"https:\/\/www.med.unc.edu\/cfar\/?p=18586"},"modified":"2025-07-18T11:24:26","modified_gmt":"2025-07-18T15:24:26","slug":"dr-lindsey-james-receives-2025-hettleman-prize-for-groundbreaking-research","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/cfar\/2025\/07\/dr-lindsey-james-receives-2025-hettleman-prize-for-groundbreaking-research\/","title":{"rendered":"Dr. Lindsey James Receives 2025 Hettleman Prize for Groundbreaking Research"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-18587\" src=\"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-300x300.jpg\" alt=\"\" width=\"474\" height=\"474\" srcset=\"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-300x300.jpg 300w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-1024x1024.jpg 1024w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-150x150.jpg 150w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-768x768.jpg 768w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-1536x1536.jpg 1536w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-2048x2048.jpg 2048w, https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-600x600.jpg 600w\" sizes=\"auto, (max-width: 474px) 100vw, 474px\" \/><\/p>\n<p><span data-contrast=\"none\">The UNC Center for AIDS Research recognizes Lindsey James, PhD, for being named a 2025 Hettleman Prize recipient\u2014one of UNC\u2019s highest honors for early-career faculty demonstrating exceptional achievement and promise in scholarly research. Dr. James is a faculty member in the UNC Eshelman School of Pharmacy\u2019s Division of Chemical Biology and Medicinal Chemistry, where she leads the James Lab, and was nominated by Dr. Angela Kashuba for this award.<\/span><\/p>\n<p><span data-contrast=\"none\">Her research lies at the intersection of chemistry and biology, focusing on controlling gene expression through the development of small molecules. These specialized compounds are designed to either block or degrade proteins that regulate gene activity\u2014some of which have long been considered \u201cundruggable.\u201d Many of these proteins play critical roles in cancer progression, and successfully targeting them, Dr. James\u2019 work opens exciting new avenues for therapeutic development.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559738&quot;:322,&quot;335559739&quot;:322,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u00a0This innovative approach has major implications not only for cancer treatment but also for advancing HIV cure strategies, where precise control over gene and protein expression remains a key challenge.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559738&quot;:322,&quot;335559739&quot;:322,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Congratulations Dr. James on this well-earned recognition of her groundbreaking work and its potential to shape the future of biomedical research.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The UNC Center for AIDS Research recognizes Lindsey James, PhD, for being named a 2025 Hettleman Prize recipient\u2014one of UNC\u2019s highest honors for early-career faculty demonstrating exceptional achievement and promise in scholarly research. Dr. James is a faculty member in the UNC Eshelman School of Pharmacy\u2019s Division of Chemical Biology and Medicinal Chemistry, where she &hellip; <a href=\"https:\/\/www.med.unc.edu\/cfar\/2025\/07\/dr-lindsey-james-receives-2025-hettleman-prize-for-groundbreaking-research\/\" aria-label=\"Read more about Dr. Lindsey James Receives 2025 Hettleman Prize for Groundbreaking Research\">Read more<\/a><\/p>\n","protected":false},"author":120087,"featured_media":18587,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-18586","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-300x300.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-768x768.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-1024x1024.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/cfar\/wp-content\/uploads\/sites\/1380\/2025\/07\/Social-Media-Post-717-150x150.jpg","featured_image_alt":"","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/cfar\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts\/18586","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/users\/120087"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/comments?post=18586"}],"version-history":[{"count":3,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts\/18586\/revisions"}],"predecessor-version":[{"id":18590,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/posts\/18586\/revisions\/18590"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/media\/18587"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/media?parent=18586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/categories?post=18586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/cfar\/wp-json\/wp\/v2\/tags?post=18586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}