Samir Kelada, PhD
We use unbiased, genome-wide approaches to identify the contributions of genetic variation, environmental exposures, and their interactions in airway diseases. To identify these interactions, we utilize powerful mouse genetic reference populations and unique exposure paradigms in concert with genomic and bioinformatic methods. We are particularly focused on using airway gene expression as a way to link genetic variation to disease phenotypes.
Our current projects are designed to identify genes and pathways that mediate:
(1) the development of allergic airway disease in response to exposure to allergens and air pollution
(2) pulmonary innate immune responses to pathogens and injurious agents
For more information (including publications), please see our lab website: keladalab.web.unc.edu