|Assistant Professor Infectious Disease
Department of Population Health & Pathobiology, College of Veterinary Medicine
North Carolina State University
The Theriot laboratory is interested in understanding how antibiotics alter the gastrointestinal microbiota and metabolome to allow for Clostridium difficile colonization and infection. We use relevant animal models of disease to study the bacterial communities and metabolites required by C. difficile to colonize the gut. We also use in vitro and ex vivo models to test hypotheses regarding C. difficile colonization. Currently we are exploring the role of microbial-mediated bile acids in altering colonization of the pathogen C. difficile, the gut microbiota, and the host response.