{"id":2216,"date":"2016-06-14T11:12:27","date_gmt":"2016-06-14T15:12:27","guid":{"rendered":"https:\/\/med-cgibd.sites.unc.edu\/center-members\/arthur-janelle\/"},"modified":"2019-08-22T14:31:58","modified_gmt":"2019-08-22T18:31:58","slug":"arthur-janelle","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/arthur-janelle\/","title":{"rendered":"Janelle Arthur, PhD"},"content":{"rendered":"

<\/p>\n

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<\/p>\n\n\n\n
\"arthur_janelle\"<\/p>\n
\n

Contact Information<\/h4>\n

6104 Marsico Hall
\nCB#7290
\n(O) 919-966-2206
\njanelle_arthur@med.unc.edu<\/a><\/p>\n

Website Links<\/h4>\n

PubMed<\/a>
\nWebsite<\/a><\/p>\n<\/div>\n<\/th>\n

 Assistant Professor
\nDept. of Microbiology & Immunology
\nSchool of Medicine
\nUniversity of North Carolina at Chapel Hill
\n<\/span><\/strong><\/span><\/p>\n

Research Summary<\/strong><\/h4>\n

Janelle Arthur is a microbiologist\/immunologist who seeks to define mechanisms by which inflammation-associated alterations to the gut microbiota influence mammalian disease processes. Her laboratory investigates how the functional capabilities and molecular features of resident microbes impact mucosal colonization, inflammatory bowel diseases (IBD), and inflammation-associated pathologies including fibrosis and tumorigenesis.\u00a0 Dr. Arthur\u2019s postdoctoral work revealed a pro-carcinogenic role for inflammation-associated intestinal E. coli <\/em>that produce a small molecule termed Colibactin.\u00a0 Her current studies have revealed a novel role for intestinal E. coli<\/em> siderophores (iron-binding small molecules) to promote inflammation-associated fibrosis, a significant complication in many IBD patients.\u00a0 Her lab performs basic and translational research combining microbiology, immunology, genomics, bioinformatics, and gnotobiotic mouse models to identify inflammatory, pro-carcinogenic, and pro-fibrotic resident bacteria and define mechanisms by which these bacteria promote disease.\u00a0 Ultimately this research will uncover novel microbial targets and enable us to manipulate the intestinal microbiota as a therapeutic target for many human digestive diseases.<\/p>\n

Relevance of Research to CGIBD Mission: <\/strong>The focus of Dr. Arthur\u2019s research is to understand how specific functional capabilities and molecular features of resident microbes impact mucosal colonization and drive inflammation-associated pathologies including fibrosis and tumorigenesis.\u00a0<\/strong><\/p>\n

CGIBD Focus Area(s):\u00a0\u00a0<\/strong>Microbiome<\/p>\n

Collaborators:<\/strong>\u00a0 Azcarate-Peril, Carroll, Fodor, Galanko, Gulati, Hansen, Magness, Sartor<\/p>\n

 <\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Contact Information 6104 Marsico Hall CB#7290 (O) 919-966-2206 janelle_arthur@med.unc.edu Website Links PubMed Website Assistant Professor Dept. of Microbiology & Immunology School of Medicine University of North Carolina at Chapel Hill Research Summary Janelle Arthur is a microbiologist\/immunologist who seeks to define mechanisms by which inflammation-associated alterations to the gut microbiota influence mammalian disease processes. 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