{"id":2232,"date":"2012-08-14T19:50:00","date_gmt":"2012-08-14T23:50:00","guid":{"rendered":"https:\/\/med-cgibd.sites.unc.edu\/center-members\/bultman-scott\/"},"modified":"2019-05-10T08:03:52","modified_gmt":"2019-05-10T12:03:52","slug":"bultman-scott","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/bultman-scott\/","title":{"rendered":"Scott Bultman, PhD"},"content":{"rendered":"\n\n\n
\"Bultman,<\/span><\/p>\n

Contact Information<\/h4>\n

4345 MBRB – CB#7264
\nUNC Chapel Hill
\nChapel Hill NC 27599-7264
\n(O)919-843-6473
\n(F) 919-843-4682
\nscott_bultman@med.unc.edu<\/a><\/p>\n

Website Links<\/h4>\n

PubMed<\/a><\/td>\n

\n

Associate Professor
\nDepartment of Genetics
\nSchool of Medicine
\nUniversity of North Carolina at Chapel Hill<\/span><\/strong><\/span><\/p>\n

Research Summary<\/strong><\/h4>\n

Scott Bultman utilizes mouse models of human disease to study the role of gut microbiota and their metabolites in colorectal cancer. He has used gnotobiotic mouse models to investigate the bacterial fermentation of dietary fiber into butyrate, a short-chain fatty acid that has potent energetic and epigenetic properties and functions as a tumor-suppressive metabolite. This work has led to papers in high-impact journals such as Cell Metabolism, Molecular Cell,<\/em> and Cancer Discovery<\/em>. In collaboration with CGIBD members Scott Magness and Nancy Allbritton he is working to develop intestinal organoids that more accurately model the anatomical and physiological characteristics of in vivo <\/em>crypts. Another project, in collaboration with Matthew Redinbo, \u00a0is evaluating the efficacy and mechanism of bacterial \u03b2-glucuronidase inhibitors that prevent the reactivation of irinotecan in the GI tract to attenuate GI toxicity and improve cancer therapy.<\/p>\n

Relevance of Research to CGIBD Mission: <\/strong>\u00a0Scott Bultman uses gnotobiotic models to investigate the role of dietary fiber and colorectal cancer. He is also using intestinal organoids that more accurately model intestinal crypts. .<\/p>\n

CGIBD Focus Area(s): \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>Microbiome; Regenerative Medicine\/Repair<\/p>\n

Collaborators: \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>Allbritton, Bhatt, Magness, Redinbo<\/p>\n

 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Contact Information 4345 MBRB – CB#7264 UNC Chapel Hill Chapel Hill NC 27599-7264 (O)919-843-6473 (F) 919-843-4682 scott_bultman@med.unc.edu Website Links PubMed Associate Professor Department of Genetics School of Medicine University of North Carolina at Chapel Hill Research Summary Scott Bultman utilizes mouse models of human disease to study the role of gut microbiota and their metabolites … Read more<\/a><\/p>\n","protected":false},"author":10853,"featured_media":4747,"parent":0,"menu_order":18,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2232","page","type-page","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nScott Bultman, PhD | Center for Gastrointestinal Biology and Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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