{"id":2237,"date":"2012-08-14T19:50:00","date_gmt":"2012-08-14T23:50:00","guid":{"rendered":"https:\/\/med-cgibd.sites.unc.edu\/center-members\/chen-xiaoxin-luke\/"},"modified":"2019-05-10T08:05:35","modified_gmt":"2019-05-10T12:05:35","slug":"chen-xiaoxin-luke","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/chen-xiaoxin-luke\/","title":{"rendered":"Xiaoxin (Luke)Chen, MD, PhD"},"content":{"rendered":"\n\n\n
\"chenl\"<\/span><\/p>\n
\n

Contact Information<\/h4>\n

Cancer Research Program, JLC-BBRI
\n700 George Street
\nDurham NC 27707
\n(O) 919-530-6425
\n(F) 919-530-7780
\nxiaoxinc@med.unc.edu<\/a><\/p>\n

Website Links<\/h4>\n

PubMed<\/a><\/p>\n<\/div>\n<\/td>\n

 Professor
\nDepartment of Biological and Biomedical Sciences
\nJulius L. Chambers Biomedical\/Biotechnology Research Institute
\nCancer Research Program
\nNorth Carolina Central University
\n<\/span> <\/strong><\/span><\/p>\n

Research Summary<\/strong><\/h4>\n

Luke Chen received education and training in clinical medicine in China. As a PhD student, postdoc, and research assistant professor at Rutgers University, he established and characterized animal models of oro-esophageal diseases with a clear goal of translational research. He was also trained in research pathology. At NCCU, he expanded his research on oro-esophageal diseases using various animal models, cell culture and human tissues. In collaboration with CGIBD member Nicholas Shaheen, Dr. Chen focused on the molecular mechanisms of Barrett\u2019s esophagus. He used various in vivo and in vitro model systems to understand how intestinal and squamous transcription factors play a role in the development of Barrett\u2019s. His current research concerns the role of the Nrf2\/Keap1 pathway in esophageal development and esophageal diseases. In particular, he has shown that the Nrf2\/Keap1 pathway regulates terminal differentiation, tight junctions and metabolism of esophageal squamous epithelial cells.<\/p>\n

Relevance of Research to CGIBD Mission: <\/strong>\u00a0The focus of Dr. Chen\u2019s research is esophageal disease including esophageal development, metabolism and disease.\u00a0 He has studied Barrett\u2019s esophagus and squamous cancer of the esophagus.<\/p>\n

CGIBD Focus Area(s):\u00a0\u00a0<\/strong>Clinical\/Translational Medicine; Regenerative Medicine\/Repair<\/p>\n

Collaborators:\u00a0\u00a0<\/strong>Shaheen<\/p>\n

 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Contact Information Cancer Research Program, JLC-BBRI 700 George Street Durham NC 27707 (O) 919-530-6425 (F) 919-530-7780 xiaoxinc@med.unc.edu Website Links PubMed Professor Department of Biological and Biomedical Sciences Julius L. Chambers Biomedical\/Biotechnology Research Institute Cancer Research Program North Carolina Central University Research Summary Luke Chen received education and training in clinical medicine in China. 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