{"id":2301,"date":"2012-08-14T19:50:00","date_gmt":"2012-08-14T23:50:00","guid":{"rendered":"https:\/\/med-cgibd.sites.unc.edu\/center-members\/sartor-ryan\/"},"modified":"2019-05-30T12:34:46","modified_gmt":"2019-05-30T16:34:46","slug":"sartor-ryan","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/sartor-ryan\/","title":{"rendered":"R. Balfour Sartor, MD"},"content":{"rendered":"\n\n\n
\"sartor_b\"<\/span><\/p>\n
\n

Contact Information<\/h4>\n

7309A Medical Biomolecular Research Building (MBRB)
\n111 Mason Farm Road, CB# 7032
\nChapel Hill, NC 27599-7032
\n(O) 919 966-0149
\n(F) 919 843-6899
\nrbs@med.unc.edu<\/a><\/p>\n

Website Links<\/h4>\n

PubMed<\/a><\/p>\n<\/div>\n<\/td>\n

Margaret and Lorimer W. Midget Distinguished Professor
\nDept. of Medicine, Division of Gastroenterology and Hepatology
\nDept. of Microbiology and Immunology
\nSchool of Medicine
\nCo-Director, Center for Gastrointestinal Biology and Disease
\nDirector, Gnotobiotic Core
\nUniversity of North Carolina at Chapel Hill
\n<\/span> <\/strong><\/span><\/p>\n

Research Summary<\/strong><\/h4>\n

Balfour Sartor is a board-certified gastroenterologist with expertise in managing difficult-to-treat patients with inflammatory bowel diseases (IBD) and a mucosal immunologist\/microbiologist with a long-term interest in understanding mechanisms by which resident microbiota induce chronic intestinal inflammation vs. mucosal homeostasis. His research develops and studies rodent models of chronic, immune-mediated intestinal inflammation relevant to IBD and performs clinically relevant translational studies involving IBD patients. He investigates host genetically-determined immune responses to luminal resident microbial components using gnotobiotic mice and patient-derived samples, and studies the influence of environmental factors on intestinal microbiota composition and function. He has provided pivotal data demonstrating the key role of resident enteric bacteria in driving chronic colitis and small intestinal inflammation. He has shown the essential role of resident enteric bacteria in inducing and maintaining enterocolitis using genetically engineered rodent models. More recently he has investigated the differential ability of various resident microbiota species to stimulate protective immune responses in normal hosts, with a pivotal observation that IL-10 secreted by antigen-presenting cells in response to resident microbiota is a key determinant of mucosal protection against chronic inflammation by inducing regulatory T cells<\/p>\n

Relevance of Research to CGIBD Mission: <\/strong>The research that Balfour Sartor conducts is pivotal to the mission of the CGIBD. He has pioneered research on the critical role of enteric microbes in driving intestinal inflammation. He has directed the Gnotobiotic Core, used by many members of the CGIBD and others. He has directed a T32 that has helped train the next generation of GI researchers, supporting the training mission of the CGIBD.\u00a0 He has attracted collaborators from many departments.<\/p>\n

CGIBD Focus Area(s):\u00a0\u00a0<\/strong>Microbiome<\/p>\n

Pilot Feasibility Award 1988<\/strong><\/p>\n

Collaborators:\u00a0\u00a0<\/strong>Bartelt, Carroll, Fodor, Furey, Gulati, Hansen, Herfarth, Long, Maio, Sheikh, Tamayo, Ting, Tonkonogy<\/p>\n

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Contact Information 7309A Medical Biomolecular Research Building (MBRB) 111 Mason Farm Road, CB# 7032 Chapel Hill, NC 27599-7032 (O) 919 966-0149 (F) 919 843-6899 rbs@med.unc.edu Website Links PubMed Margaret and Lorimer W. Midget Distinguished Professor Dept. of Medicine, Division of Gastroenterology and Hepatology Dept. of Microbiology and Immunology School of Medicine Co-Director, Center for Gastrointestinal … Read more<\/a><\/p>\n","protected":false},"author":10853,"featured_media":4747,"parent":0,"menu_order":62,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2301","page","type-page","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nR. 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