{"id":3104,"date":"2017-11-30T09:34:06","date_gmt":"2017-11-30T14:34:06","guid":{"rendered":"https:\/\/med-cgibd.sites.unc.edu\/?page_id=3104"},"modified":"2021-02-23T10:46:23","modified_gmt":"2021-02-23T15:46:23","slug":"miao-edward","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/miao-edward\/","title":{"rendered":"Edward Miao, MD, PhD"},"content":{"rendered":"

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Contact Information<\/h4>\n

Duke University
\n3 Genome Court; DUMC Box 103054<\/p>\n

MSRB3 40124 (lab 3250)
\nDurham, NC 27710<\/p>\n

Email Dr. Miao<\/a><\/p>\n

Website Links<\/h4>\n

Website<\/a><\/p>\n

PubMed<\/a><\/p>\n

<\/h4>\n<\/div>\n<\/th>\n

\n
Associate Professor
\nDept. of Microbiology & Immunology<\/span><\/strong><\/div>\n
School of Medicine
\nUniversity of North Carolina at Chapel Hill
\n<\/span><\/strong><\/div>\n

Research Summary<\/strong><\/h4>\n

We study how the immune system combats intracellular pathogens. The most direct mechanism to reverse intracellular replication is to trigger programmed cell death. Our laboratory has long focused on pyroptotic cell death, which is triggered when inflammasomes detect pathogens, activate caspase-1 or caspase-11, thereby initiating the gasdermin D pore to cause pyroptosis. We have described how inflammasomes detect pathogens, and how pyroptosis results in their destruction. We are now expanding to consider other forms of programmed cell death, both cell intrinsic as well as cell death initiated by natural killer cells and cytotoxic T lymphocytes.\u00a0 We study a variety of bona fide bacterial pathogens that typically evade immune defenses (e.g. Salmonella<\/em> and Listeria<\/em>) and compare these to environmental pathogens where immune defenses confer perfect elimination of the pathogen (e.g. Burkholderia<\/em> and Chromobacterium<\/em>).<\/p>\n

Relevance of Research to CGIBD Mission: <\/strong> Most of the pathogens we study target the intestines or other digestive organs for infection. For example, Salmonella<\/em> and Listeria<\/em> cause intestinal infection, and we are studying the role of programmed cell death in defense in the intestine. We also have a strong interest in liver (a digestive organ that feeds directly into the intestines via bile secretion.\u00a0 Among our chief interests are Listeria<\/em> and Chromobacterium<\/em>, which are highly tropic for liver infection. The Miao lab is a former CGIBD pilot\/feasibility recipient, and collaborates with several CGIBD members.<\/p>\n

CGIBD Focus Area(s):\u00a0\u00a0<\/strong>Microbiome<\/p>\n

Collaborators:\u00a0\u00a0<\/strong>Carroll, Fodor, Hansen, Sartor, Ting<\/p>\n<\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/h4>\n","protected":false},"excerpt":{"rendered":"

Contact Information Duke University 3 Genome Court; DUMC Box 103054 MSRB3 40124 (lab 3250) Durham, NC 27710 Email Dr. Miao Website Links Website PubMed Associate Professor Dept. of Microbiology & Immunology School of Medicine University of North Carolina at Chapel Hill Research Summary We study how the immune system combats intracellular pathogens. The most direct … Read more<\/a><\/p>\n","protected":false},"author":13588,"featured_media":4747,"parent":0,"menu_order":48,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-3104","page","type-page","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nEdward Miao, MD, PhD | Center for Gastrointestinal Biology and Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cgibd\/miao-edward\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Edward Miao, MD, PhD | Center for Gastrointestinal Biology and Disease\" \/>\n<meta property=\"og:description\" content=\"Contact Information Duke University 3 Genome Court; DUMC Box 103054 MSRB3 40124 (lab 3250) Durham, NC 27710 Email Dr. Miao Website Links Website PubMed Associate Professor Dept. of Microbiology & Immunology School of Medicine University of North Carolina at Chapel Hill Research Summary We study how the immune system combats intracellular pathogens. 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