{"id":3602,"date":"2019-02-28T10:56:56","date_gmt":"2019-02-28T15:56:56","guid":{"rendered":"https:\/\/www.med.unc.edu\/cgibd\/?page_id=3602"},"modified":"2019-07-31T08:46:34","modified_gmt":"2019-07-31T12:46:34","slug":"bhatt-aadra-2","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/bhatt-aadra-2\/","title":{"rendered":"Aadra Bhatt, PhD"},"content":{"rendered":"

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\"Photo<\/h4>\n

Contact Information<\/h4>\n

7312A\u00a0MBRB
\nCB#7032
\n(O) 919-843-4598
\naadra_bhatt@med.unc.edu<\/a><\/p>\n

Website Links<\/h4>\n

PubMed<\/a><\/p>\n<\/div>\n<\/th>\n

 Assistant Professor
\nDept. of Medicine, Division of Gastroenterology and Hepatology
\nSchool of Medicine
\nUniversity of North Carolina at Chapel Hill
\n<\/span><\/strong><\/span><\/p>\n

Research Summary<\/strong><\/h4>\n

Dr. Bhatt has studied the interplay between persistent microorganisms and the host in a variety of physiologic contexts. As a graduate student, she discovered the mechanisms by which a persistent oncogenic herpesvirus induces cancer by reprogramming host cellular signaling and metabolism. During her postdoctoral training with Dr. Matthew Redinbo, she worked alongside structural and chemical biologists to uncover mechanisms by which the intestinal microbiota impacts the incidence and progression of cancer, and how microbial enzymes alter the therapeutic efficacy of anticancer compounds. In collaboration with Dr. Nancy Allbritton, she has developed tools to study host- microbe-drug interactions ex vivo<\/em> using organotypic cell culture platforms. As a new Assistant Professor at UNC, she is combining her multidisciplinary training to uncover reciprocal interactions between the intestinal microbiota and pharmaceutical compounds, and their implications on host gastrointestinal health.<\/p>\n

Relevance of Research to CGIBD Mission:<\/strong>\u00a0 Dr. Bhatt\u2019s multidisciplinary research is directly in line with the CGIBD\u2019s mission statement: it combines the diverse disciplines of chemical and structural biology to study how intestinal microbiota can alter the metabolism of various pharmaceutical compounds, and the resultant effects on the intestinal epithelium. By including gnotobiotic mouse models of inflammatory bowel disease, in addition to wild type mice, Dr. Bhatt is executing granular and mechanistic studies of host-microbiota interactions, and how they impact gastrointestinal health.<\/p>\n

CGIBD Focus Area(s):\u00a0\u00a0<\/strong>Microbiome<\/p>\n

Pilot and Feasibility Award 2019<\/strong><\/p>\n

\u00a0<\/strong>Collaborators:\u00a0\u00a0<\/strong>Allbritton, Bultman, Magness, Redinbo<\/p>\n

 <\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Contact Information 7312A\u00a0MBRB CB#7032 (O) 919-843-4598 aadra_bhatt@med.unc.edu Website Links PubMed Assistant Professor Dept. of Medicine, Division of Gastroenterology and Hepatology School of Medicine University of North Carolina at Chapel Hill Research Summary Dr. Bhatt has studied the interplay between persistent microorganisms and the host in a variety of physiologic contexts. As a graduate student, she … Read more<\/a><\/p>\n","protected":false},"author":57486,"featured_media":4747,"parent":0,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-3602","page","type-page","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nAadra Bhatt, PhD | Center for Gastrointestinal Biology and Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cgibd\/bhatt-aadra-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aadra Bhatt, PhD | Center for Gastrointestinal Biology and Disease\" \/>\n<meta property=\"og:description\" content=\"Contact Information 7312A\u00a0MBRB CB#7032 (O) 919-843-4598 aadra_bhatt@med.unc.edu Website Links PubMed Assistant Professor Dept. of Medicine, Division of Gastroenterology and Hepatology School of Medicine University of North Carolina at Chapel Hill Research Summary Dr. Bhatt has studied the interplay between persistent microorganisms and the host in a variety of physiologic contexts. 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