{"id":3734,"date":"2019-03-01T12:27:03","date_gmt":"2019-03-01T17:27:03","guid":{"rendered":"https:\/\/www.med.unc.edu\/cgibd\/?page_id=3734"},"modified":"2019-05-10T07:46:11","modified_gmt":"2019-05-10T11:46:11","slug":"gracz-adam","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/","title":{"rendered":"Adam Gracz, PhD"},"content":{"rendered":"

<\/p>\n

<\/p>\n

<\/p>\n\n\n\n
\"\"<\/p>\n
\n

Contact Information<\/h4>\n

The University of North Carolina at Chapel Hill
\n4331 MBRB
\nCB#7032
\n(O) 919-843-4578<\/p>\n

mailto:agracz@email.unc.edu<\/a><\/p>\n

Website Links<\/h4>\n

PubMed<\/a><\/p>\n

<\/h4>\n<\/div>\n<\/th>\n

\n
Assistant Professor
\nDept. of Genetics
\nSchool of Medicine
\nUniversity of North Carolina at Chapel Hill
\n<\/span><\/strong><\/span>
\n<\/span><\/strong><\/span><\/div>\n

Research Summary<\/strong>\u00a0<\/strong><\/p>\n

Adam Gracz investigates how chromatin regulation contributes to homeostasis, regeneration, and disease in adult gastrointestinal stem cells. The current research objective of his lab is to delineate the regulatory nature of chromatin dynamics in intestinal stem cells (ISCs). His pre- and postdoctoral training focused on the development of novel tools for ISC biology, as well as applying these tools to mechanistic studies of transcriptional regulation in ISCs. He has contributed to research at the forefront of ISC identification, isolation, and manipulation in vitro<\/em>. This work has resulted in transgenic and cell surface markers of mouse and human ISCs, culture conditions for active and reserve human ISCs, a high-throughput platform facilitating functional and genetic manipulation of single ISCs and organoids for downstream analysis, and the identification of the first secretory transcription factor capable of driving intestinal differentiation in the absence of Atoh1<\/em>. He is an early stage investigator who draws on his established strengths to pursue novel and independent questions in ISC genomics and biliary epithelial cell biology.<\/p>\n

Relevance of Research to CGIBD Mission: <\/strong>\u00a0The questions asked by Dr. Gracz are fundamental to our basic understanding of GI and biliary epithelia. He has been a major beneficiary of the CGIBD.\u00a0 He was supported by our T32 in basic GI. He received a pilot\/feasibility grantin 2015 from the Center. He takes advantage of the Advanced Analytics and the Biostatistics and Clinical Research Cores.<\/p>\n

CGIBD Focus Area(s):\u00a0\u00a0<\/strong>Regenerative Medicine\/Repair<\/p>\n

Pilot and Feasibility Award 2016<\/strong><\/p>\n

Collaborators:\u00a0\u00a0<\/strong>Magness, Allbritton, Galanko<\/p>\n

\u00a0<\/strong><\/p>\n

 <\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/h4>\n","protected":false},"excerpt":{"rendered":"

Contact Information The University of North Carolina at Chapel Hill 4331 MBRB CB#7032 (O) 919-843-4578 mailto:agracz@email.unc.edu Website Links PubMed Assistant Professor Dept. of Genetics School of Medicine University of North Carolina at Chapel Hill Research Summary\u00a0 Adam Gracz investigates how chromatin regulation contributes to homeostasis, regeneration, and disease in adult gastrointestinal stem cells. The current … Read more<\/a><\/p>\n","protected":false},"author":57486,"featured_media":4747,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-3734","page","type-page","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nAdam Gracz, PhD | Center for Gastrointestinal Biology and Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adam Gracz, PhD | Center for Gastrointestinal Biology and Disease\" \/>\n<meta property=\"og:description\" content=\"Contact Information The University of North Carolina at Chapel Hill 4331 MBRB CB#7032 (O) 919-843-4578 mailto:agracz@email.unc.edu Website Links PubMed Assistant Professor Dept. of Genetics School of Medicine University of North Carolina at Chapel Hill Research Summary\u00a0 Adam Gracz investigates how chromatin regulation contributes to homeostasis, regeneration, and disease in adult gastrointestinal stem cells. The current … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/\" \/>\n<meta property=\"og:site_name\" content=\"Center for Gastrointestinal Biology and Disease\" \/>\n<meta property=\"article:modified_time\" content=\"2019-05-10T11:46:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1466\" \/>\n\t<meta property=\"og:image:height\" content=\"392\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@unc_cgibd\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/\",\"url\":\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/\",\"name\":\"Adam Gracz, PhD | Center for Gastrointestinal Biology and Disease\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg\",\"datePublished\":\"2019-03-01T17:27:03+00:00\",\"dateModified\":\"2019-05-10T11:46:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg\",\"width\":1466,\"height\":392,\"caption\":\"MBRB Staircase\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/cgibd\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Adam Gracz, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/cgibd\/\",\"name\":\"Center for Gastrointestinal Biology and Disease\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/cgibd\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/#organization\",\"name\":\"Center for Gastrointestinal Biology and Disease\",\"url\":\"https:\/\/www.med.unc.edu\/cgibd\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2017\/06\/cgibd_logo-e1558013708733.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2017\/06\/cgibd_logo-e1558013708733.png\",\"width\":292,\"height\":195,\"caption\":\"Center for Gastrointestinal Biology and Disease\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/cgibd\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/x.com\/unc_cgibd\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Adam Gracz, PhD | Center for Gastrointestinal Biology and Disease","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/","og_locale":"en_US","og_type":"article","og_title":"Adam Gracz, PhD | Center for Gastrointestinal Biology and Disease","og_description":"Contact Information The University of North Carolina at Chapel Hill 4331 MBRB CB#7032 (O) 919-843-4578 mailto:agracz@email.unc.edu Website Links PubMed Assistant Professor Dept. of Genetics School of Medicine University of North Carolina at Chapel Hill Research Summary\u00a0 Adam Gracz investigates how chromatin regulation contributes to homeostasis, regeneration, and disease in adult gastrointestinal stem cells. The current … Read more","og_url":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/","og_site_name":"Center for Gastrointestinal Biology and Disease","article_modified_time":"2019-05-10T11:46:11+00:00","og_image":[{"width":1466,"height":392,"url":"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@unc_cgibd","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/","url":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/","name":"Adam Gracz, PhD | Center for Gastrointestinal Biology and Disease","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/cgibd\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg","datePublished":"2019-03-01T17:27:03+00:00","dateModified":"2019-05-10T11:46:11+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#primaryimage","url":"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg","contentUrl":"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2019\/05\/Member-banner-for-member-pages.jpg","width":1466,"height":392,"caption":"MBRB Staircase"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/cgibd\/gracz-adam\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/cgibd\/"},{"@type":"ListItem","position":2,"name":"Adam Gracz, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/cgibd\/#website","url":"https:\/\/www.med.unc.edu\/cgibd\/","name":"Center for Gastrointestinal Biology and Disease","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/cgibd\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/cgibd\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/cgibd\/#organization","name":"Center for Gastrointestinal Biology and Disease","url":"https:\/\/www.med.unc.edu\/cgibd\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/cgibd\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2017\/06\/cgibd_logo-e1558013708733.png","contentUrl":"https:\/\/www.med.unc.edu\/cgibd\/wp-content\/uploads\/sites\/466\/2017\/06\/cgibd_logo-e1558013708733.png","width":292,"height":195,"caption":"Center for Gastrointestinal Biology and Disease"},"image":{"@id":"https:\/\/www.med.unc.edu\/cgibd\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/unc_cgibd"]}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/pages\/3734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/users\/57486"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/comments?post=3734"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/pages\/3734\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/media\/4747"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cgibd\/wp-json\/wp\/v2\/media?parent=3734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}