{"id":5125,"date":"2019-07-31T09:14:28","date_gmt":"2019-07-31T13:14:28","guid":{"rendered":"https:\/\/www.med.unc.edu\/cgibd\/?page_id=5125"},"modified":"2019-07-31T09:14:28","modified_gmt":"2019-07-31T13:14:28","slug":"surana_neil","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/surana_neil\/","title":{"rendered":"Neil Surana, MD, PhD"},"content":{"rendered":"

<\/p>\n

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\"Photo<\/h4>\n

Contact Information<\/h4>\n

(O) 919-613-8742
\nneil.surana@duke.edu<\/a><\/p>\n

Website Links<\/h4>\n

Website<\/a><\/p>\n

PubMed<\/a><\/p>\n<\/div>\n<\/th>\n

 Assistant Professor
\nDept. of Pediatrics (Infectious Diseases), Molecular Genetics and Microbiology, and Immunology
\nDuke University
\n<\/span><\/strong><\/span><\/p>\n

Research Summary<\/strong><\/h4>\n

The Surana lab innovatively integrates gnotobiotic murine models, immunology, microbiology, and characterization of the microbiota with the ultimate aim of identifying specific commensal bacteria with immunomodulatory potential and subsequent characterization of their biologic effects. We have recently developed an inventive approach for identifying with high specificity organisms within the microbiota that are causally related to the phenotype of interest. Using this approach of microbe\u2013phenotype triangulation, we identified\u00a0Clostridium immunis<\/em>, a\u00a0new bacterial species that protects against colitis in murine models, and two bacterial species that induce host expression of a critical antimicrobial peptide. We are now investigating the molecular mechanisms\u2014from both the bacterial and host perspectives\u2014that underlie these host\u2013commensal relationships. Furthermore, we are extending our discovery platform to human samples and additional disease processes to identify more causal microbes.<\/p>\n

Relevance of Research to CGIBD Mission: <\/strong>The Surana lab\u2019s research is germane to the CGIBD mission of improving our understanding of host\u2013commensal interactions, particularly as it relates to intestinal biology and colitis.<\/p>\n

CGIBD Focus Area(s):<\/strong>\u00a0 Microbiome, Regenerative Medicine\/Repair<\/p>\n

Collaborators:\u00a0\u00a0<\/strong>John Rawls<\/p>\n

 <\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

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