{"id":5638,"date":"2020-04-23T17:12:40","date_gmt":"2020-04-23T21:12:40","guid":{"rendered":"https:\/\/www.med.unc.edu\/cgibd\/?page_id=5638"},"modified":"2020-04-23T17:12:40","modified_gmt":"2020-04-23T21:12:40","slug":"li-xiaoling","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cgibd\/li-xiaoling\/","title":{"rendered":"Xiaoling Li, PhD"},"content":{"rendered":"

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Contact Information<\/h4>\n

111 T.W. Alexander Drive
\nBuilding 101, Rm. F239A
\nResearch Triangle Park, NC 27709
\n(O) 984-287-3484<\/p>\n

lix3@niehs.nih.gov<\/a><\/p>\n

Website Links<\/h4>\n

Webpage<\/a><\/p>\n

PubMed<\/a><\/p>\n

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Senior Investigator
\nMetabolism, Genes, and Environment Group
\nSignal Transduction Laboratory
\nNational Institute of Environmental Health Sciences<\/span><\/strong><\/span><\/span><\/div>\n

Research Summary<\/strong><\/p>\n

Dr. Li\u2019s long-term goal is to understand the signal transduction that coordinates the gene-environment interaction in biological processes associated with metabolic homeostasis, and investigate how dysregulation of this interplay contributes to pathogenesis of metabolic diseases and aging. To achieve this goal, her group focuses on NAD+<\/sup> metabolism, SIRT1, a highly conserved NAD+<\/sup>-dependent protein deacylase, and protein lysine acylation. Using mice and cultured cells as model systems, the group combines molecular, cellular, and genetic approaches to study the functions of these factors\/processes in regulation of metabolism, stress response, intestinal tissue homeostasis, development, and ultimately aging. The current research areas include host-microbe interaction in host NAD metabolism and related (patho)physiology; host regulation of gut microbiota in intestinal tissue homeostasis, inflammation, and tumorigenesis; metabolic and epigenetic regulation of stem cell functions and embryogenesis; and metabolic and epigenetic regulation of tumorigenesis. <\/span><\/p>\n

Relevance of Research to CGIBD Mission:\u00a0 <\/strong>Dr. Li\u2019s research combines the diverse disciplines of biology to study how gut microbiota interacts with nutrients to impact metabolism and homeostasis of host tissues, particularly intestinal epithelium. By focusing on inflammatory bowel disease and colorectal cancer using genetically modified mouse strains and gnotobiotic mouse models, Dr. Li\u2019s research is directly in line with the CGIBD\u2019s mission. Their studies have the potential to lead to novel therapies for a number of metabolism-related intestinal diseases.<\/span><\/p>\n

CGIBD Focus Area(s):\u00a0 <\/strong>Gut microbiota, nutrient metabolism, IBD, CRC<\/p>\n

Collaborators:\u00a0 <\/strong>Sandler, Keku, Azcarate-Peril, Gulati<\/p>\n

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Contact Information 111 T.W. Alexander Drive Building 101, Rm. F239A Research Triangle Park, NC 27709 (O) 984-287-3484 lix3@niehs.nih.gov Website Links Webpage PubMed Senior Investigator Metabolism, Genes, and Environment Group Signal Transduction Laboratory National Institute of Environmental Health Sciences Research Summary Dr. Li\u2019s long-term goal is to understand the signal transduction that coordinates the gene-environment interaction … Read more<\/a><\/p>\n","protected":false},"author":87626,"featured_media":4747,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-5638","page","type-page","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nXiaoling Li, PhD | Center for Gastrointestinal Biology and Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cgibd\/li-xiaoling\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Xiaoling Li, PhD | Center for Gastrointestinal Biology and Disease\" \/>\n<meta property=\"og:description\" content=\"Contact Information 111 T.W. 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