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UNC School of Medicine | Department of Pediatrics
Advancing the health of children in North Carolina and beyond

Ongoing Clinical Trials

Available clinical trials in the UNC Department of Pediatrics vary by division, specialty or center. Additional information about clinical trials and their availability may be found by visiting Research for Me, which is administered by the North Carolina Translational and Clinical Sciences Institute (NCTraCS), or ClinicalTrials.gov. For divisions with active or ongoing clinical trials, experienced research teams include both clinicians and coordinators who specialize in care and management of pediatric populations impacted by common or rare diseases.

It is important to note that while some clinical trials are open and enrolling, others are closed or maintain waitlists for prospective participants. Also, some clinical trials are administered by faculty from the Department of Pediatrics, but only recruit adults.

Area of StudyStudy TitleTarget AgeContact Information
Adolescent Health and Well-BeingCognition and Neuroimaging in TeensElementary, TeenHannah Waltz
919-843-9671
Adolescent Health and Well-BeingEVOLVE Study: Understanding risk for depression in the pubertal transitionElementary, TeenElizabeth Andersen
evolvestudy@unc.edu
Adolescent Health and Well-BeingProNET: Psychosis Risk Outcomes NetworkElementary, TeenJennifer Nieri
jennifer_nieri@med.unc.edu
877-774-6319
Adolescent Health and Well-BeingStories of high schooler activity participation after a health eventTeenRachel Vaughn
rachel_vaughn@med.unc.edu
Adolescent Health and Well-BeingHigh Schoolers and Activities after an Unexpected Health EventTeenRachel Vaughn
rachel_vaughn@med.unc.edu
Adolescent Health and Well-BeingTeen Cycle StudyTeenAriana Davis
ariana.davis@unc.edu
Adolescent Health and Well-BeingAdolescent Mood during Puberty and Testosterone (AMPT)TeenKayla Jensen
NERDlab@unc.edu
919-445-6815
Adolescent Health and Well-BeingTeens, Emotions, and Social Interactions StudyTeenCope Feurer
TeenEmotionStudy@med.unc.edu
919-966-0861
AllergiesIdentification of Allergen Epitopes in Individuals with Peanut AllergyPreschool, Elementary, Teen, AdultDeanna Hamilton
919-962-4405
AllergiesOmalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen OIT in Food Allergic Participants (OUtMATCH)Preschool, Elementary, Teen, AdultSarah Bennick
919-962-4409
Lauren Herlihy
919-962-4406
AllergiesHydrolyzed Formula in Infants and Children with Cow's Milk AllergyInfant, Preschool, ElementaryLauren Herlihy
foodallergy@unc.edu
AllergiesUNC Food Allergy RegistryInfant, Preschool, Elementary, Teen, AdultLauren Herlihy
foodallergy@unc.edu
AllergiesPeanut Allergy StudyElementary, Teen, AdultEmily English
919-962-4961
ArthritisLimit JIAPreschool, Elementary, TeenCorinne Lawler
corinne.lawler@unc.edu
919-962-9841
AsthmaUNC Asthma Registry for KidsInfant, Preschool, Elementary, Teen, AdultMiriam Davis
919-966-2333
AsthmaEAGLE: Efficacy Assessment in recurrent wheezing childrenElementary, Teen, AdultSheila Joshi
Sheila_Joshi@unc.edu
919-843-1577
AsthmaIndividualizing Treatment for Asthma in Primary CareTeen, AdultiTREAT_Study@unc.edu
919-843-4401
Attention-Deficit Hyperactivity DisorderBrain Maturation Across Puberty in ADHD (BrainMAP)ElementaryAlexa Monachino
919-843-3753
Behavior and DevelopmentSpectra DiscoveryPreschool, ElementaryRegan Burney
spectra@unc.edu
919-966-8598
Behavior and DevelopmentBrain and Early Experiences StudyInfant, Preschool, Elementary, Teen, AdultCathi Propper
BEEstudy@unc.edu
Bones, Joints and MusclesPediatric ACL Walking, Jumping, and CuttingElementary, Teen, AdultCourtney Chaaban
rosscj@live.unc.edu
Bones, Joints and MusclesACL Research StudyTeen, AdultDevin Kelly
orthoresearch@med.unc.edu
Bones, Joints and MusclesACL Surgery Rehabilitation StudyTeen, AdultTroy Blackburn
troyb@email.unc.edu
Bones, Joints and MusclesBiomechanical Changes Following ACL Injury that Influence PTOATeen, AdultBrian Pietrosimone
pietrosi@email.unc.edu
Bones, Joints and MusclesEffect of Skeletal Maturity on Biomarkers for Posttraumatic OA After ACL InjuryElementary, TeenBrian Pietrosimone
pietrosi@email.unc.edu
Bones, Joints and MusclesVirtual Reality ACL Reconstruction StudyTeenShelby Baez
sbaez@unc.edu
Bones, Joints and MusclesImproving Walking Patterns in Individuals with an ACL ReconstructionTeen, AdultCortney Armitano
919-962-0396
Bones, Joints and MusclesBrain Function after ACL ReconstructionTeen, AdultShelby Baez
sbaez@unc.edu
Bones, Joints and MusclesSimple Bone Cysts in Kids (SBoCK)Preschool, Elementary, Teen, AdultJulie Titter
919-966-5495
Bones, Joints and MusclesValidity of Force Detecting Insoles for Gait Biofeedback after ACLRTeen, AdultAlyssa Evans
678-381-3636
CancerAdministration of Autologous CAR-T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch in Patient with Acute Lymphoblastic LeukemiaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
919-445-4208
CancerTargeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)Infant, Preschool, Elementary, Teen, AdultJuanita Ramirez
877-668-0683
CancerETERNITY: Biorepository to accelerate advances in Radiation TherapyInfant, Preschool, Elementary, Teen, AdultMelissa Knutsen
919-966-4432
CancerExpanded Access Protocol Using 131I-MIBGInfant, Preschool, Elementary, Teen, AdultJuanita Ramirez
919-966-5785
CancerMIBG With DinutuximabPreschool, Elementary, Teen, AdultJuanita Ramirez
877-668-0683
CancerA Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic LeukemiaInfant, Preschool, Elementary, Teen, AdultJuanita Ramirez
919-966-1178
CancerA Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)Infant, Preschool, Elementary, Teen, AdultKimberly Kasow
919-966-1178
CancerNab-Paclitaxel and Gemcitabine for Recurrent/Refractory SarcomaElementary, Teen, AdultJuanita Cuffee
919-843-7025
CancerStudy of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory NeuroblastomaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
919-445-4208
CancerStudy of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHLPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
919-445-4208
CancerA study to test an oral medicine, belumosudil, in combination with corticosteroids in participants at least 12 years of age with newly diagnosed chronic graft versus host disease.Teen, AdultJanell Markey
janell_markey@med.unc.edu
CancerVenetoclax and Azacitidine in Patients with Acute Myeloid Leukemia after TransplantTeen, AdultJanell Markey
janell_markey@med.unc.edu
919-966-1568
CancerUnderstanding Outcome Differences in Adolescents and Young Adults with Acute Lymphoblastic Leukemia (ALL)Teen, Adultcancerclinicaltrials@med.unc.edu
919-966-4432
CancerUNC Childhood, Adolescent, and Young Adult Cancer RegistryInfant, Preschool, Elementary, Teen, AdultAndrew Smitherman, MD MSc
andrew_smitherman@med.unc.edu
919-966-1178
CancerImprove Adherence to Childhood Cancer SurvivorshipInfant, Preschool, Elementary, Teen, AdultLineberger Clinical Research
cancerclinicaltrials@med.unc.edu
919-966-4432
CancerPediatric Oncology Tissue to Support Further ResearchInfant, Preschool, Elementary, Teen, AdultLineberger Clinical Research
cancerclinicaltrials@med.unc.edu
919-966-4432
CancerMeasuring body composition in childhood cancerElementary, Teen, AdultLineberger Clinical Research
cancerclinicaltrials@med.unc.edu
919-966-4432
Cerebral PalsyHand Weakness in Children with Cerebral PalsyElementary, TeenMiranda Ludovice
mcludovi@ncsu.edu
770-883-8399
Charcot-Marie-Tooth diseasePharnext CLN-PXT3003-06 PREMIER studyTeen, Adult Manisha Chopra
919-843-7857
Cognition and MemoryMemory and Perception in AdolescenceElementary, Teen, AdultAslihan Imamoglu
cnmlabcognition@unc.edu
919-695-7983
COVID-19Epidemiological and Immunological Aspects of COVID-19Infant, Preschool, Elementary, Teen, AdultMichelle Kennedy
984-209-3326
COVID-19Pediatric COVID‐19 Booster Vaccine in Autoimmune Non-RespondersElementary, Teen, AdultCorinne Lawler
corinne.lawler@unc.edu
919-962-9841
COVID-19PREVENT-COVID: A Study for IBD Patients who have Received a COVID-19 VaccineTeen, AdultKimberly Weaver
preventcovid@unc.edu
COVID-19The PREVNC StudyInfant, Preschool, Elementary, Teen, AdultKatie Mills
PREVNCstudy@unc.edu
COVID-19Long-term immunologic responses to COVID-19 infection and vaccinationElementary, Teen, AdultUsaphea P. Vanna
usaphea@ad.unc.edu
COVID-19Pandemic Response RepositoryInfant, Preschool, ElementarySandy Grubbs
sandy_grubbs@med.unc.edu
Dental Healthwater from Bottles to Establish Strong Teeth (waterBEST)InfantSonya K Capps
sonya_capps@unc.edu
919-537-3269
Dental HealthDental Anxiety in Young Dental PatientsPreschool, ElementaryNare Ghaltakhchyan
jlab@unc.edu
984-234-1858
Developmental DisordersIBIS Early Prediction StudyInfant, PreschoolShannon Sweeney
919-843-1331
Developmental DisordersRegistry for Autism, Fragile X Syndrome, and Intellectual and Developmental DisabilitiesInfant, Preschool, Elementary, Teen, AdultRenee Clark
919-966-5232
Developmental DisordersFLASH StudyInfant, PreschoolJessica Steinbrenner
flash_study@unc.edu
Developmental DisordersComparing executive functioning in children with or without ADHD or ASDElementaryClare Harrop
clare_harrop@med.unc.edu
Developmental DisordersGender and Autism ProjectElementary, Teen, AdultSallie Nowell
GAP@unc.edu
Developmental DisordersStudying brain development in infants with developmental disordersInfant, PreschoolJulia Gross
julia_gross@med.unc.edu
919-966-8032
Developmental DisordersEthnic-Racial Socialization Practices among Black Youth with Neurodevelopmental DisabilitiesElementary, Teen, AdultNicole Telfer
blackfamiliesstudy@unc.edu
Developmental DisordersToddler Remote Assessment of Virtual Eye tracking and Language StudyInfant, Preschool, Elementary, Teen, AdultJessica Goldblum
jessgold@live.unc.edu
DiabetesType 1 Diabetes RegistryInfant, Preschool, Elementary, Teen, AdultKlara Klein
klara_klein@med.unc.edu
DiabetesDeveloping treatments for type 1 diabetesElementary, Teen, AdultRoland Tisch
919-966-4766
Down SyndromeIBIS Down Syndrome Imaging StudyInfant, PreschoolShannon Sweeney
919-843-1331
Ear, Nose and Throat; Lungs and BreathingMapping the Pediatric Inhalation Interface: Nose, Mouth, and AirwaysInfant, Preschool, Elementary, TeenParis Bennett
UNCMP2@unc.edu
Ear, Nose and ThroatCochlear Implants for Babies and Toddlers with Single-Sided DeafnessInfant, Preschool, Elementary, Teen, AdultMichelle Bocanegra
CIResearch@unc.edu
Eating, Nutrition, and MetabolismAn avocado intervention to increase the nutrient quality of human milk in support of infant cognitive development.Infant, AdultMandi Rider
feedingbrains@unc.edu
Eating, Nutrition, and MetabolismMinds & MilkshakesTeenBrian Brown
NIBL@unc.edu
Eating, Nutrition, and MetabolismARFID Genes and EnvironmentElementary, Teen, AdultMelissa Chernoff
melissa_chernoff@med.unc.edu
EczemaEczema Research StudyElementary, Teen, AdultLauren Herlihy
lekoch@email.unc.edu
Eosinophilic EsophagitisEoE Tooth Fairy Study: Environmental Risk Factors for Eosinophilic Esophagitis (EoE)Preschool, Elementary, Teen,Kacie Walker
toothfairystudy@med.unc.edu
Eosinophilic EsophagitisIndividualized Diet Elimintation for Treatment of Eosinophilic Esophagitis (EoE)Teen, AdultTim Gee
timothy_gee@med.unc.edu
Eosinophilic EsophagitisEosinophilic Esophagitis Drug TrialTeen, AdultLoyanna Hubbard
loyanna_hubbard@med.unc.edu
Eosinophilic GastritisEosinophilic Gastritis StudyTeen, AdultHiwot Ekuban
hiwot_ekuban@med.unc.edu
Eosinophilic Gastritis or GastroenteritisEosinophilic gastritis and gastroenteritis StudyTeen, AdultAriel Watts
919-843-0821
Hereditary Hemorrhagic TelangiectasiaMulticenter study to learn more about brain avms and bleeding in people with Hereditary Hemorrhagic Telangiectasia (HHT)Infant, Preschool, Elementary, Teen, AdultKaren Smith
919-966-2790
Hearing LossVestibular/Balance and Hearing Loss StudyElementaryGraham Cochrane
graham.cochrane@unchealth.unc.edu
401-862-2263
Hearing LossChildren with Hearing Loss Sleep StudyElementaryJulia Drouin
allearslab@med.unc.edu
Inflammatory, Allergic, and Chronic Gastrointestinal DiseasesTissue Repository for Inflammatory & Allergic Chronic GI diseasesInfant, Preschool, Elementary, TeenGwen Lau
gwen_lau@med.unc.edu
919-843-8107
Inflammatory Bowel DiseaseIBD Partners Kids & TeensInfant, Preschool, Elementary, TeenLaura Weisbein
919-843-7828
Inflammatory Bowel DiseaseThe Pediatric IBD Network Improvement CollaborativePreschool, Elementary, Teen, AdultParis Bennett
paris_bennett@med.unc.edu
Juvenile ArthritisInvestigating Biologic Drugs in Children with ArthritisInfant, Preschool, Elementary, Teen, AdultTeresa Dickson
tad6@med.unc.edu
919-962-8241
Kidney DiseaseCureGN (Cure Glomerulonephropathy)Infant, Preschool, Elementary, Teen, AdultMaggie D'Angelo
919-619-1773
Kidney DiseaseGDCN RegistryInfant, Preschool, Elementary, Teen, AdultKristin Brock
919-445-2623
Kidney DiseaseLIPOSORBER LA-15 system for Adult and Pediatric FSGSElementary, Teen, AdultAnne Froment
919-445-2622
Kidney DiseaseEvaluating Problematic Proteinuria in Kids (EPPIK)Infant, Preschool, Elementary, TeenAnne Froment
kidneytrials@unc.edu
919-445-2622
Liver A Prospective, Observational, Non-Interventional, Post-Marketing, Patient Registry to Collect Data on Routine Clinical Care in Patients Treated with Cholbam®/Kolbam® (Cholic Acid)Infant, Preschool, Elementary, TeenParis Bennett
paris_bennett@med.unc.edu
LupusAurora VOCAL Study for Adolescents with Lupus NephritisTeenAnne Froment
kidneytrials@unc.edu
Medication and Vaccine EfficacyPharmacokinetics and Safety of Drugs in Lactating Women and Breastfed InfantsInfant, Teen, AdultJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Medication and Vaccine EfficacyPharmacokinetics of Off Label Pediatric MedicationsInfant, Preschool, ElementaryJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Medication and Vaccine EfficacySafety of Sildenafil in Premature Infants (SIL02)InfantJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Medication and Vaccine EfficacyPharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS or POP02)Infant, Preschool, Elementary, Teen, AdultJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Mental and Emotional HealthThe Life Experiences and Emotion Development (LEED) StudyElementaryAdam Miller
LEEDstudy@rti.org
910-477-3712
Mental and Emotional HealthSuicide Prevention Study For Black YouthTeen, AdultSonyia Richardson
scopelan@unc.edu
Mental and Emotional HealthLatina Mother and Child Immune Health StudyPreschool, AdultRebeca Alvarado Harris
rebeca@email.unc.edu
Multiple ScelrosisPediatric Relapsing Remitting Multiple Sclerosis StudyElementary, Teen, AdultPatricia Orozco
919-966-5039
Muscle WeaknessBrain Imaging in Pediatric Hemiplegia (Muscle Weakness)Elementary, TeenJessica Cassidy
jcassidy@med.unc.edu
919-843-577
NeurodevelopmentBlood and Neural Biomarkers for Brain Health in ChildrenElementary, TeenHadden LaGarde
CCN@med.unc.edu
Nephrotic SyndromeINShore: is the drug obinutizumab helpful in children with nephrotic syndrome?Preschool, Elementary, Teen, AdultFernanda Ochoa Toro
feroacha@med.unc.edu
NeurodevelopmentGenetic Determinants of Neurological and Developmental DisordersInfant, Preschool, Elementary, Teen, AdultSheila Joshi
919-966-9051
NeurodevelopmentPediatric Brain Imaging StudyInfant, Preschool, ElementaryJordan Jimenez
jordan_jimenez@med.unc.edu
NeurodevelopmentEarly Life Factors (ELF) StudyInfant, AdultThao Nguyen
ELFstudy@unc.edu
919-445-2869
NutritionInfant Nutrition & Cognition StudyInfant, AdultMelissa Shaffer
704-250-5018
ObesityUNC Nutritional Research Institute Children Health StudyElementary, Teen, AdultBrea Nance
704-250-5055
OsteoarthritisMove with Support - Muevete con ApoyoTeen, AdultSandra Soto
919-966-4298
OsteomyelitisCHronic nonbacterial Osteomyelitis International Registry (CHOIR)Infant, Preschool, Elementary, Teen, AdultTeresa Dickson
919-962-8241
Sickle Cell DiseaseEarly Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell TransplantationPreschool, ElementaryKimberly Kasow
919-966-1178
Sickle Cell DiseaseSTRIDE BiorepositoryTeen, AdultKimberly Kasow
919-966-1178
Speech TherapySpeech Therapy Device StudyElementary, Teen, AdultLynn Fox
lynn_fox@unc.edu
Speech, Dentofacial AbnormalitiesOrthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses (OSP)Teen, AdultSherrill Phillips
sherrill_phillips@unc.edu
Tuberous Sclerosis ComplexRegulating Together in TSCElementary, Teen, AdultJustin Birudavol
justin.birudavol@cidd.unc.edu