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Computational Medicine Program’s First Symposium

September 19, 2019 @ 9:00 am - 4:30 pm

Featured Speakers

Elaine Mardis, PhD

Nationwide Children’s Hospital

Elaine Mardis, PhD, is co-Executive Director of the Institute for Genomic Medicine at Nationwide Children’s Hospital and the Nationwide Foundation Endowed Chair in Genomic Medicine. She also is Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Mardis joined Nationwide Children’s Hospital in 2016.

Educated at the University of Oklahoma with a B.S. in Zoology and a Ph.D. in Chemistry and Biochemistry, Dr. Mardis did postgraduate work in industry at BioRad Laboratories. She was a member of the faculty of Washington University School of Medicine from 1993-2016. Dr. Mardis has authored over 350 articles in prestigious peer-reviewed journals and has written book chapters for several medical textbooks. She serves as an associate editor for three peer-reviewed journals (Disease Models and Mechanisms, Molecular Cancer Research, and Annals of Oncology) and is Editor-in-Chief of Molecular Case Studies, published by Cold Spring Harbor Press. Dr. Mardis has given lectures at scientific meetings worldwide, and was awarded the Morton K Schwartz award from the American Association for Clinical Chemistry in 2016. She has been listed since 2013 as one of the most highly cited researchers in the world by Thompson Reuters. Dr. Mardis has been a member of the American Association for Cancer Research (AACR) since 2007, was the program committee chair for the 2018 AACR Annual Meeting, and is the AACR President-elect.

 

Trey Ideker, PhD

University of California San Diego

Dr. Ideker is a Professor of Medicine at UC San Diego. He is the Director of the National Resource for Network Biology, the San Diego Center for Systems Biology, and the Cancer Cell Map Initiative. He is a pioneer in using genome-scale measurements to construct network models of cellular processes and disease. The Ideker Lab is working to create artificially intelligent models of cancer and other diseases for translation of patient data to precision diagnosis and treatment.

 

Michael Yaffe, MD, PhD

Massachusetts Institute of Technology

Professor Yaffe is the David H. Koch Professor of Science and Professor of Biology and Biological Engineering at MIT, where he has been a faculty member since 2000; he is also an attending trauma surgeon at the Beth Israel Deaconess Medical Center. Yaffe earned his doctoral degree in biophysical chemistry and his medical degree from Case Western Reserve University. He completed residencies in both general surgery and surgical oncology, at University Hospitals of Cleveland and New England Deaconess Hospital, respectively, and a fellowship in surgical critical care at Harvard Medical School’s Harvard-Longwood Critical Care Program. He was a postdoctoral fellow with Lewis Cantley in the Department of Cell Biology at Harvard Medical School. In recognition of his accomplishments, he received the Howard Hughes Physician Scientist Award, the Burroughs Wellcome Career Development Award, and the MIT Science Teaching Prize. A founder of Consensus Pharmaceuticals, the DNA Repair Company, and Merrimack Pharmaceuticals, Professor Yaffe is also the Chief Scientific Editor of Science Signaling. He serves as a Colonel in the U.S. Army Reserve Medical Corps and in 2015 received the Bronze Star Medal from the U.S. Army for his service as a trauma surgeon on active duty in Afghanistan. In 2017, Yaffe became the inaugural scientific director of the MIT Center for Precision Cancer Medicine.

 

 

Anne-Lisa Borresen-Dale, PhD

Oslo University Hospital

Anne-Lise Børresen-Dale is Professor Emerita at University of Oslo and previous head of Department of Cancer Genetics, Oslo University Hospital Radiumhospitalet. She is among the leading geneticists in research on molecular biology of breast cancer, and her group was among the pioneers in expression profiling of breast carcinomas in collabora¬tion with groups at Stanford, demonstrating that breast cancer can be divided into distinct sub-groups with differences in molecular profiles and in overall and relapse-free survival. Her achievements are seminal for understanding breast cancer evolution, and have had an enormous impact on our view of the complexity of breast cancer. She is author of more than 600 published scientific papers, books chapters and invited reviews.

 

 

Andrea Califano

Andrea Califano, Dr.

Columbia University Medical Center

Andrea Califano is the Clyde and Helen Wu Professor of Chemical and Systems Biology at Columbia University Medical Center. He is the Founding Chair of the Department of Systems Biology, Director of the JP Sulzberger Columbia Genome Center, and Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center, and also holds appointments in the Department of Biochemistry & Molecular Biophysics and Department of Biomedical Informatics. He is a member of the National Academy of Medicine and a fellow of the ISCB, AAAS, and IEEE. The Califano Lab uses a combination of computational and experimental methodologies to reconstruct the regulatory logic of human cells in genome-wide fashion to identify master regulator proteins responsible for human disease, including cancer and neurodegenerative syndromes.

 

 

Peter Sorger, PhD

Harvard Medical School

Peter received his AB from Harvard College, PhD from Trinity College, Cambridge University U.K., under the supervision of Hugh Pelham and trained as a postdoctoral fellow at the University of California, San Francisco with Harold Varmus and Andrew Murray. Prior to coming to HMS Peter served as a Professor of Biology and Biological Engineering at MIT.

Peter’s research focuses on the systems biology of signal transduction networks controlling cell proliferation and death, the dysregulation of these networks in cancer and inflammatory diseases and the mechanisms of action of therapeutic drugs targeting signaling proteins. His group uses mathematical and experimental approaches to construct and test computational models of signaling in human and murine cells as a means to understand and eventually predict the responses of cells and tumors to drugs applied individually and in combination. The Sorger group also develops open-source software for analyzing biological networks and it participates in multiple collaborative programs working to improve data reproducibility.

As founding head of the Harvard Program in Therapeutic Sciences (HiTS), Peter leads a university-wide effort to advance the basic and translational science used to develop new medicines, identify responsive patients and evaluate new drugs via precision clinical trials. He also directs the primary research program in HiTS, the Laboratory of Systems Pharmacology, which joins together faculty members from six institutions in a multi-disciplinary effort to develop and apply new concepts in drug discovery. Peter was a co-founder of Merrimack Pharmaceuticals and Glencoe Software and is an adviser to multiple public and private companies and research institutes in the US, Europe, and Japan.

 

Jeremy Purvis

Jeremy Purvis, PhD

University of North Carolina

Jeremy Purvis is an Associate Professor of Genetics at the University of North Carolina at Chapel Hill, where he serves as a member of the Lineberger Comprehensive Cancer Center, the Curriculum for Bioinformatics and Computational Biology, and the Computational Medicine Program. He received a Ph.D. in Genomics and Computational Biology at the University of Pennsylvania under the mentorship of Scott Diamond and Ravi Radhakrishnan. He then trained under Galit Lahav at Harvard Medical School, where he studied the functional role of p53 dynamics by blending computational modeling and single-cell imaging. In 2013, he established his independent research group at UNC, which focuses on building computational models of cell cycle progression and early cell fate decisions during human development. Dr. Purvis is the recipient of a CAREER Award from the National Science Foundation, the NIH Director’s New Innovator Award, and a Medical Research Award from the W. M. Keck Foundation.

Thank you to our symposium sponsors

10X Genomics                       illumina Inc             VWR

Parking

Dogwood Dek and Bioinformatics Building

Please be aware there is road construction on West Drive and visitors parking is available at Dogwood Deck at an hourly rate.

Road Construction Map

Details

Date:
September 19, 2019
Time:
9:00 am - 4:30 pm
Event Category:

Venue

Bioinformatics Building, Room 1131
130 Mason Farm Rd
Chapel Hill, NC 27514 United States
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