CompMed Research in Progress
2023-09-08 10:00 - 11:00 (America/New_York) | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Emma Crawford (Stanley Lab)
Talk Title: Learning How to Modulate and Tune the Immune System

CompMed Research in Progress
2023-09-15 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Jamie Madrigal
Talk Title: Modeling Enzyme Kinetics in the Presence of Lipids

CompMed Seminar
2023-09-28 14:00 - 15:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Pratip Chattopadhyay, Ph.D.
CEO and Founder of Talon Biomarkers
Talk Title: ” From Full Spectrum Flow Cytometry to Fully Interpretable Biology”

CompMed Research in Progress
2023-10-06 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Sarah Patterson
Talk title: “Curative Chemotherapy Regimens in Germ Cell Tumors”

CompMed Research in Progress
2023-10-13 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Jinan Wang, PhD
Talk Title: “Ligand Gaussian Accelerated Molecular Dynamics 3 (LiGaMD3): Improved Calculations of Ligand and Peptide Binding Kinetics”

CompMed Research in Progress
2023-11-03 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Yixiang Qu (Di Wu Lab)
Talk Title: BGOB: A new deep learning method for microbiome time series analysis

CompMed Research in Progress
2023-11-10 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Garrett Sessions (Purvis Lab)
Talk Title: Tracing the Temporal Dynamics of Senescence Induction

CompMed Research in Progress
2023-11-17 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Sana Akhter (Miao Lab)
Talk Title: “Mechanism of ligand binding to theophylline RNA aptamer”

CompMed Research in Progress
2023-12-01 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Tarek Zikry (Purvis Lab)
Talk Title: Mechanism of ligand binding to theophylline RNA aptamer

CompMed Research in Progress
2023-12-08 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Brian Gural (Rau Lab)
Talk Title: “Defining Cardiac Cellular Compositional Changes by Deconvolution in a Mouse Model of Heart Failure”

CompMed Research in Progress
2023-12-15 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Victor Adediwura (Miao Lab)
Talk Title: “Mechanistic insights into peptide binding and deactivation of an adhesion G Protein-coupled receptor”

No CompMed Research in Progress
2024-01-05 10:00 - 11:00 | NC
No meeting today

CompMed Research in Progress
2024-01-12 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Tim Daugrid (Legant Lab)
Talk Title: Navigating the nuclear microenvironment: Single-molecule imaging and modeling approaches to studying transcription factor search kinetics

Seminar
2024-01-18 14:00 - 15:00 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
Presenter: Hui Shen, Ph.D.
Professor, Van Andel Institute
Hosted by Katherine Hoadley, Ph.D.
Title: Ovarian cancer ‘epigenetics’ through the lens of novel single cell technologies

CompMed Research in Progress
2024-01-19 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Caroline Moosmueller
Talk Title: Optimal transport as a tool for single-cell data analysis

CompMed Research in Progress
2024-02-02 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Yash Agrawal (Perou Lab)
Talk Title: Analysis of gene expression features correlating with survival from the GEICAM/2013-02 PEARL trial with Cox regression and high-dimensional modeling

CompMed Research in Progress
2024-02-09 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Harlin Lee, Ph.D., Assistant Professor, School of Data Science and Society
Talk Title: ” Self-supervised learning in multimodal pediatric sleep signals”

Seminar
2024-02-15 14:00 - 15:00 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
Presenter: Michael K. Gilson, Ph.D.
Distinguished Professor
Skaggs School of Pharmacy and Pharmaceutical Sciences,
University of California San Diego, LaJolla, CA
Hosted by: Yinglong Miao, Ph.D.
Talk Title: “Mining Minimal Affinity Calculations and the BindingDB Database, Tools for Drug Discovery”
About the speaker:

Grew up in New York City.
A.B. Bioengineering at Harvard College, 1981
MD-PHD program at Columbia College of Physicians and Surgeons in New York City, 1981-1989. PhD in Biochemistry and Molecular Biophysics.
Part 1 (inpatient) of internal medicine residency (Clinical Investigator Pathway) at Stanford University Hospital, Palo Alto, CA, 1989-1991
Part 2 (outpatient and research) of Internal medicine residence at Baylor College of Medicine, Houston, TX 1991-1993.
Postdoctoral fellowship as Howard Hughes Physician Medical Fellow at the University of Houston, with Prof. J Andrew McCammon, 1991-1994
CARB Fellow and Assistant Professor to Professor, Center for Advanced Research in Biotechnology (CARB), Rockville, MD, 1994-2010.
Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, 2010-present.

“My lab has focused on the development of the physical chemistry theory of non-covalent binding and methods and software for computer-aided drug design. We also originated and continue to run BindingDB, a large database of measured protein-small molecule binding data used by researchers worldwide. Recently, we have worked to improve the potential functions used in molecular simulations, have done theoretical work on the mechanisms of molecular motors, and have worked on the use of artificial intelligence in drug discovery”

CompMed Research in Progress
2024-02-16 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Guorong Wu (PI)
Talk title: Understand novel mechanism using machine learning techniques

Research in Progress
2024-03-01 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Stephanie Ting (Hoadley Lab)
Talk title: Computational Analysis of Cancer-Adjacent Normal Breast Tissue

Research in Progress
2024-03-08 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Yifan Dai( Di Wu Lab)
Talk Title: Interpretable prediction using machine learning methods in longitudinal microbiome data

2nd Computational Medicine Symposium
2024-03-13 10:00 - 16:30 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
“From Single Cells to Microenvironments: Computational Medicine at Multiple Scales”
Itai Yanai, Ph.D. New York University “Cellular plasticity and developmental constraints in cancer”
Alexander Anderson, Ph.D. Moffit Cancer Center ” Evolutionary Therapy”
Amanda Randles, Ph.D. Duke University “Developing circulatory digital twins for improved healthcare”
Jeff Hasty, Ph.D. The University of California San Diego “Engineered bacteria for cancer therapeutics and diagnostics”
Stacey Finley, Ph.D. The University of Southern California “Tumor-immune ecosystem: quantitative insights from modeling across scales”

No Research in Progress
2024-03-15 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
There is no meeting today. Enjoy your weekend!

CompMed Seminar
2024-03-21 14:00 - 15:00 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
Presenter: Dr. Benjamin Izar, MD, PhD
Assistant Professor, Columbia University Irving Medical Center/New York Presbyterian
Talk title: “From Sequence to Mechanisms and Therapies”
Dr. Benjamin Izar is the Vivian and Seymour Milstein Family assistant professor at Columbia University Vagelos College of Physicians and Surgeons, Department of Medicine, Division of Hematology and Oncology. His research program leverages large-scale single-cell genomics studies and functional screens to dissect and overcome mechanisms of cancer immune evasion. Recent work has investigated the intersection of cancer genomics, metastatic progression, and immunobiology in melanoma and non-small cell lung cancer. These studies informed novel drug targets to disrupt immunosuppressive cues and enable a new generation of cellular immunotherapies.

BioTech Day
2024-04-03 13:00 - 18:00 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
Half Day Symposium

1:30 – 1:55: Joel Parker, LifeEdit Therapeutics: BCB at LifeEdit Therapeutics
1:55 – 2:20: Anupama Reddy, Vindhya Data Science: Biomarker Development to Enhance Precision Medicine, Translating ‘Omics Signatures to the Clinic
2:20 – 2:45: Victor Weigman, Bioskryb Genomics: Understanding Molecular Impacts of Gene Therapies Through Multi-Omic Profiling of Individual Cells
Coffee Break
2:55 – 3:20: Marshall Thompson, Rare Cancer Research Foundation: Direct Patient Participation in Oncology Research as a Catalyst for Innovation
3:20 – 3:45: Sara Selitsky, Tempus AI: Development of a Prognostic Signature Through Molecular Subtyping of a Rare Squamous Cancer
3:45 – 4:10: Nicholas Dietrich, Kriya Therapeutics: Next Generation Sequencing and Gene Therapy Product Development
4:10 – 4:35: Mariano Alvarez, Avalo: Interpretable Machine Learning for Discovery and Prediction Tasks in Commerical Breeding Programs
Coffee Break
4:45 – 5:10: Mark Lovern, InSilicoTrials: Introduction to Model-Informed Drug Development
5:10 – 5:35: Umut Eser, Weave: Challenges and Opportunities of Modernizing the Drug Development Process with AI
5:35 – 6:00: Marcel Frenkel, Ten63: Molecular Voxel Theory, Exploring Vast Chemical and Conformational Space to Drug the Undruggable

RSVP HERE →

Research in Progress
2024-04-05 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Sam Wolff, Assistant Professor
Talk Title: Understanding Fractional Resistance in ER+/HER2- Breast Cancer: A Team Approach

Research in Progress
2024-04-12 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Natalie Stanley
Talk Title: Microglia Clocks of Aging

Seminar - No Meeting
2024-04-18 14:00 - 15:00 | NC
No scheduled meeting today

Research in Progress
2024-04-19 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Fariha Rahman (Legant Lab)
Talk Title: Multiplexed super-resolution fluorescence microscopy of the human nuclear

Research in Progress
2024-05-03 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Mikayla Feldbauer, Hoadley Lab
Talk Title: Spatial transcriptomic determinants of clinical-molecular congruence and subtype switching in metastatic breast cancer
