CompMed Research in Progress
2023-05-05 10:00 - 11:00 (America/New_York) | Mary Ellen Jones 3112, 116 Manning Drive, Chapel Hill, NC, 27514
Presenter: Keith Alexander Breau, Elston Lab
Talk Title: Modeling the Wnt planar cell polarity complex: coordinating cell polarity during collective migration

UNC Spring Fling
2023-05-05 11:30 - 12:00 | UNC Student Recreation Center
Join the UNC Campus Recreation staff for the annual SPRING FLING. The Spring Fling is a 2.5 mile fun run or 1.25 mile walk open to all UNC-Chapel Hill faculty and staff. In previous years, over 300 participants have completed the course individually or as part of a departmental team. The event promotes physical activity, health and well-being and provides employees with the opportunity to contribute to the local food bank by making a canned food donation. In addition, pet donations will be given to the Orange County Animal Shelter. Free refreshments will be provided for participants after the event. This event is rain or shine!
Date: Friday, May 5, 2023
Check in 11:30AM- noon
Run/Walk Time: 12:15PM
Location: in front of the Student Recreation Center
Prizes: Awards will be given to the team with the most creative costumes celebrating the SPRING season and the most spirited team.
Donations: Collections will be made for two charities this season: Non-perishable food items will be donated to a local food bank. Non-perishable pet items will be donated to the local animal shelters (food, old blankets, leashes, bowls, collars, etc. are all welcome). Those making a donation to either cause will be eligible for a special drawing.

CompMed Research in Progress
2023-05-12 10:00 - 11:00 | Mary Ellen Jones 3112, 116 Manning Drive, Chapel Hill, NC, 27514
Presenter: Elizabeth Claire Brunk, PhD
Talk Title: Extrachromosomal DNA create new gene neighborhoods to increase cell population fitness

Computational Medicine Seminar
2023-05-18 14:00 - 15:00 | NC
Presenter: Dr. Sara Mostafavi
Assistant Professor, Paul Allen School of Computer Science and Engineering
University of Washington, Seattle
Department of Statistics and Medical Genetics
Talk Title: “Deep Learning of Immune Cell Differentiation”

CompMed Research in Progress
2023-05-19 10:00 - 11:00 | Mary Ellen Jones 3112, 116 Manning Drive, Chapel Hill, NC, 27514
Presenter: Alec Plotkin
Talk Title: Trajectory Inference to Identify Drivers of CD8 T-cell Responses to Acute Infection

CompMed Research in Progress
2023-09-01 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter Dhuvi Kartikeyan (Rubinsteyn Lab)
Talk Title: Conditional Generation of Diverse TCR:pMHC Sequence Pairs Using Deep Neural Networks

CompMed Research in Progress
2023-09-08 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Emma Crawford (Stanley Lab)
Talk Title: Learning How to Modulate and Tune the Immune System

CompMed Research in Progress
2023-09-15 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Jamie Madrigal
Talk Title: Modeling Enzyme Kinetics in the Presence of Lipids

CompMed Seminar
2023-09-28 14:00 - 15:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Pratip Chattopadhyay, Ph.D.
CEO and Founder of Talon Biomarkers
Talk Title: ” From Full Spectrum Flow Cytometry to Fully Interpretable Biology”

CompMed Research in Progress
2023-10-06 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Sarah Patterson
Talk title: “Curative Chemotherapy Regimens in Germ Cell Tumors”

CompMed Research in Progress
2023-10-13 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Jinan Wang, PhD
Talk Title: “Ligand Gaussian Accelerated Molecular Dynamics 3 (LiGaMD3): Improved Calculations of Ligand and Peptide Binding Kinetics”

CompMed Research in Progress
2023-11-03 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Yixiang Qu (Di Wu Lab)
Talk Title: BGOB: A new deep learning method for microbiome time series analysis

CompMed Research in Progress
2023-11-10 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Garrett Sessions (Purvis Lab)
Talk Title: Tracing the Temporal Dynamics of Senescence Induction

CompMed Research in Progress
2023-11-17 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Sana Akhter (Miao Lab)
Talk Title: “Mechanism of ligand binding to theophylline RNA aptamer”

CompMed Research in Progress
2023-12-01 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Tarek Zikry (Purvis Lab)
Talk Title: Mechanism of ligand binding to theophylline RNA aptamer

CompMed Research in Progress
2023-12-08 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Brian Gural (Rau Lab)
Talk Title: “Defining Cardiac Cellular Compositional Changes by Deconvolution in a Mouse Model of Heart Failure”

CompMed Research in Progress
2023-12-15 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Victor Adediwura (Miao Lab)
Talk Title: “Mechanistic insights into peptide binding and deactivation of an adhesion G Protein-coupled receptor”

No CompMed Research in Progress
2024-01-05 10:00 - 11:00 | NC
No meeting today

CompMed Research in Progress
2024-01-12 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Tim Daugrid (Legant Lab)
Talk Title: Navigating the nuclear microenvironment: Single-molecule imaging and modeling approaches to studying transcription factor search kinetics

Seminar
2024-01-18 14:00 - 15:00 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
Presenter: Hui Shen, Ph.D.
Professor, Van Andel Institute
Hosted by Katherine Hoadley, Ph.D.
Title: Ovarian cancer ‘epigenetics’ through the lens of novel single cell technologies

CompMed Research in Progress
2024-01-19 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Caroline Moosmueller
Talk Title: Optimal transport as a tool for single-cell data analysis

CompMed Research in Progress
2024-02-02 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Yash Agrawal (Perou Lab)
Talk Title: Analysis of gene expression features correlating with survival from the GEICAM/2013-02 PEARL trial with Cox regression and high-dimensional modeling

CompMed Research in Progress
2024-02-09 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Harlin Lee, Ph.D., Assistant Professor, School of Data Science and Society
Talk Title: ” Self-supervised learning in multimodal pediatric sleep signals”

Seminar
2024-02-15 14:00 - 15:00 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
Presenter: Michael K. Gilson, Ph.D.
Distinguished Professor
Skaggs School of Pharmacy and Pharmaceutical Sciences,
University of California San Diego, LaJolla, CA
Hosted by: Yinglong Miao, Ph.D.
Talk Title: “Mining Minimal Affinity Calculations and the BindingDB Database, Tools for Drug Discovery”
About the speaker:

Grew up in New York City.
A.B. Bioengineering at Harvard College, 1981
MD-PHD program at Columbia College of Physicians and Surgeons in New York City, 1981-1989. PhD in Biochemistry and Molecular Biophysics.
Part 1 (inpatient) of internal medicine residency (Clinical Investigator Pathway) at Stanford University Hospital, Palo Alto, CA, 1989-1991
Part 2 (outpatient and research) of Internal medicine residence at Baylor College of Medicine, Houston, TX 1991-1993.
Postdoctoral fellowship as Howard Hughes Physician Medical Fellow at the University of Houston, with Prof. J Andrew McCammon, 1991-1994
CARB Fellow and Assistant Professor to Professor, Center for Advanced Research in Biotechnology (CARB), Rockville, MD, 1994-2010.
Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, 2010-present.

“My lab has focused on the development of the physical chemistry theory of non-covalent binding and methods and software for computer-aided drug design. We also originated and continue to run BindingDB, a large database of measured protein-small molecule binding data used by researchers worldwide. Recently, we have worked to improve the potential functions used in molecular simulations, have done theoretical work on the mechanisms of molecular motors, and have worked on the use of artificial intelligence in drug discovery”

CompMed Research in Progress
2024-02-16 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Guorong Wu (PI)
Talk title: Understand novel mechanism using machine learning techniques

Research in Progress
2024-03-01 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Stephanie Ting (Hoadley Lab)
Talk title: Computational Analysis of Cancer-Adjacent Normal Breast Tissue

Research in Progress
2024-03-08 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
Presenter: Yifan Dai( Di Wu Lab)
Talk Title: Interpretable prediction using machine learning methods in longitudinal microbiome data

2nd Computational Medicine Symposium
2024-03-13 10:00 - 16:30 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
“From Single Cells to Microenvironments: Computational Medicine at Multiple Scales”
Itai Yanai, Ph.D. New York University “Cellular plasticity and developmental constraints in cancer”
Alexander Anderson, Ph.D. Moffit Cancer Center ” Evolutionary Therapy”
Amanda Randles, Ph.D. Duke University “Developing circulatory digital twins for improved healthcare”
Jeff Hasty, Ph.D. The University of California San Diego “Engineered bacteria for cancer therapeutics and diagnostics”
Stacey Finley, Ph.D. The University of Southern California “Tumor-immune ecosystem: quantitative insights from modeling across scales”

No Research in Progress
2024-03-15 10:00 - 11:00 | Mary Ellen Jones 3116, 116 Manning Drive, Chapel Hill, NC, 27599, United States
There is no meeting today. Enjoy your weekend!

CompMed Seminar
2024-03-21 14:00 - 15:00 | Bioinformatics Building, Room 1131, 130 Mason Farm Rd, Chapel Hill, NC, 27514, United States
Presenter: Dr. Benjamin Izar, MD, PhD
Assistant Professor, Columbia University Irving Medical Center/New York Presbyterian
Talk title: “From Sequence to Mechanisms and Therapies”
Dr. Benjamin Izar is the Vivian and Seymour Milstein Family assistant professor at Columbia University Vagelos College of Physicians and Surgeons, Department of Medicine, Division of Hematology and Oncology. His research program leverages large-scale single-cell genomics studies and functional screens to dissect and overcome mechanisms of cancer immune evasion. Recent work has investigated the intersection of cancer genomics, metastatic progression, and immunobiology in melanoma and non-small cell lung cancer. These studies informed novel drug targets to disrupt immunosuppressive cues and enable a new generation of cellular immunotherapies.
