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X-ORIGINAL-URL:https://www.med.unc.edu/compmed
X-WR-CALDESC:Events for Computational Medicine
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DTSTART;TZID=America/New_York:20210205T100000
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CREATED:20201110T192553Z
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SUMMARY:Comp Med Research in Progress
DESCRIPTION:Presenter: Hannah Janine Perrin / Karen Mohlke Lab \nTalk Title: “Chromatin accessibility during adipocyte differentiation identifies context-dependent effects for cardiometabolic traits”
URL:https://www.med.unc.edu/compmed/event/comp-med-research-in-progress-26/
LOCATION:NC
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2020/11/Hannah-Janine-Perrin.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210212T100000
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CREATED:20201110T192943Z
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UID:10000223-1613124000-1613127600@www.med.unc.edu
SUMMARY:Comp Med Research in Progress
DESCRIPTION:Presenter: Wancen Wu / Michael Love Lab \nTalk Title: “Differential allelic imbalance across groups of cells”
URL:https://www.med.unc.edu/compmed/event/comp-med-research-in-progress-28/
LOCATION:NC
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2020/11/Wancen-Mu.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
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DTSTART;TZID=America/New_York:20210218T140000
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UID:10000277-1613656800-1613660400@www.med.unc.edu
SUMMARY:Computational Medicine Seminar
DESCRIPTION:Presenter: Kevin Janes\, PhD \nTalk Title: “Complete kinetic modeling of an RNA pathogen” \nComplete kinetic models are pervasive in chemistry but lacking in biological systems. We encoded the complete kinetics of infection for coxsackievirus B3 (CVB3)\, a compact and fast-acting RNA virus. The kinetics are built from detailed modules for viral binding–delivery\, translation–replication\, and encapsidation. Specific module activities are dampened by the type I interferon response to viral double-stranded RNAs (dsRNAs)\, which is itself disrupted by viral proteinases. The validated kinetics uncovered that cleavability of the dsRNA transducer mitochondrial antiviral signaling protein (MAVS) becomes a stronger determinant of viral outcomes when cells receive supplemental interferon after infection. Cleavability is naturally altered in humans by a common MAVS polymorphism\, which removes a proteinase-targeted site but paradoxically elevates CVB3 infectivity. These observations are reconciled with a simple nonlinear model of MAVS regulation. Modeling complete kinetics is an attainable goal for small\, rapidly infecting viruses and perhaps viral pathogens more broadly. \n\nJanes\, Kevin A.
URL:https://www.med.unc.edu/compmed/event/computational-medicine-seminar-10/
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CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2020/11/KevinJanes_headshot.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
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DTSTART;TZID=America/New_York:20210219T100000
DTEND;TZID=America/New_York:20210219T110000
DTSTAMP:20260419T062825
CREATED:20201110T192655Z
LAST-MODIFIED:20210121T190038Z
UID:10000221-1613728800-1613732400@www.med.unc.edu
SUMMARY:Comp Med Research in Progress
DESCRIPTION:Presenter: Hillary Heiling / Naim Rashid Lab \nTalk Title: “Estimating Cell Type Composition using Isoform Expression One Gene at a Time”
URL:https://www.med.unc.edu/compmed/event/comp-med-research-in-progress-27/
LOCATION:NC
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2020/11/Hillary-Heiling-1.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
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