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X-ORIGINAL-URL:https://www.med.unc.edu/compmed
X-WR-CALDESC:Events for Computational Medicine
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DTSTART:20210314T070000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20221227
DTEND;VALUE=DATE:20230103
DTSTAMP:20260617T161632
CREATED:20221128T173725Z
LAST-MODIFIED:20221128T173725Z
UID:10000346-1672099200-1672703999@www.med.unc.edu
SUMMARY:Holiday
DESCRIPTION:
URL:https://www.med.unc.edu/compmed/event/holiday/
LOCATION:NC
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230105T140000
DTEND;TZID=America/New_York:20230105T150000
DTSTAMP:20260617T161632
CREATED:20230102T175924Z
LAST-MODIFIED:20230102T175924Z
UID:10000349-1672927200-1672930800@www.med.unc.edu
SUMMARY:Faculty Candidate Seminar
DESCRIPTION:Presenter: Arjun Bhattacharya\, PhD \nDepartment of Pathology and Laboratory Medicine \nDavid Geffen School of Medicine \nUniversity of California\, Los Angeles \nTalk Title: The breadth and depth of transcriptomics to understand the genetic etiology of diseases \n  \nArjun Bhattacharya\, PhD is a Postdoctoral Fellow in the Department of Pathology and Laboratory Medicine and in Computational Medicine at the David Geffen School of Medicine at UCLA and a Fellow of the Institute for Quantitative and Computational Biosciences. He earned my PhD in Biostatistics at the University of North Carolina at Chapel Hill\, where he focused on statistical genetics\, computational genomics\, and molecular epidemiology. He develops and applies novel computational methods that integrate genetic and functional genomic data to understand complex diseases\, specifically cancer progression\, childhood neurodevelopment\, and other developmental traits.
URL:https://www.med.unc.edu/compmed/event/faculty-candidate-seminar-9/
LOCATION:Lineberger Pagano Conference Room\, 450 West Drive\, Chapel Hill\, 27599\, United States
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/Arjun-headshot.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230106T100000
DTEND;TZID=America/New_York:20230106T110000
DTSTAMP:20260617T161632
CREATED:20230102T174545Z
LAST-MODIFIED:20230102T174545Z
UID:10000348-1672999200-1673002800@www.med.unc.edu
SUMMARY:CompMed Research in Progress
DESCRIPTION:Presenter: Timothy Qi \nTalk Title: Apex predators in anti-tumor immunity
URL:https://www.med.unc.edu/compmed/event/compmed-research-in-progress-33/
LOCATION:NC
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/Timothy-Qi.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230110T160000
DTEND;TZID=America/New_York:20230110T170000
DTSTAMP:20260617T161632
CREATED:20230102T193028Z
LAST-MODIFIED:20230102T193028Z
UID:10000351-1673366400-1673370000@www.med.unc.edu
SUMMARY:Faculty Candidate Seminar
DESCRIPTION:Presenter: Haibo Ni\, PhD \nDepartment of Pharmacology\, School of Medicine \nUniversity of California\, Davis \nTalk Title: Quantitative systems physiology and pharmacology for cardiac arrhythmias \n  \nDr. Haibo Ni is an Assistant Project Scientist at the Department of Pharmacology\, University of California Davis. He obtained his Ph.D. degree in Biological Physics from the University of Manchester\, U.K.\, in 2017\, and completed postdoctoral training with Prof. Eleonora Grandi’s lab at Davis. Dr. Ni received a prestigious American Heart Association (AHA) Postdoctoral Fellowship and is a grant reviewer for AHA Fellowship programs. He has 28 peer-reviewed journal publications and one book chapter in press.\nDr. Ni’s research advances quantitative systems investigation of cardiac physiology\, pathophysiology\, and pharmacology by developing multiscale and multiphysics computational frameworks of the heart. Dr. Ni’s work focuses on applying these frameworks to dissect complex mechanisms of heart diseases and define and optimize new therapeutic strategies through in-silico drug screening and virtual clinical trials using personalized simulations\, with an emphasis on heart rhythm disorders.
URL:https://www.med.unc.edu/compmed/event/faculty-candidate-seminar-10/
LOCATION:Bioinformatics Building\, Room 1131\, 130 Mason Farm Rd\, Chapel Hill\, NC\, 27514\, United States
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/Haibo_Ni_Photo-scaled.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230112T140000
DTEND;TZID=America/New_York:20230112T150000
DTSTAMP:20260617T161632
CREATED:20230102T193740Z
LAST-MODIFIED:20230102T193740Z
UID:10000352-1673532000-1673535600@www.med.unc.edu
SUMMARY:Faculty Candidate Seminar
DESCRIPTION:Presenter: Abigail Lind\, PhD \nGladstone Institutes\, UCSF\, San Francisco\, CA \nTalk Title: From pathogens to commensals: human-associated microbial eukaryotes through the lens of genomics and evolution \n  \nHumans coexist with myriad microbes that live within and on us\, impacting our health in beneficial and detrimental ways. These microbes come from all domains of life and include bacteria\, archaea\, and eukaryotes. Eukaryotic microbes\, including protists and fungi\, are emerging as key members of the microbiome that influence other microbiota and host health in multifaceted ways. The factors that differentiate negative and positive interactions with a human host\, and mechanistically how eukaryotic microbes accomplish these impacts\, are unknown. \nI have developed methods to routinely and accurately identify eukaryotic microbes in microbiomes\, and discovered that multiple commensal protists are common members of a healthy gut. I have found that Blastocystis\, a diverse species complex of stramenopile protists\, are the most prevalent commensal gut eukaryotes worldwide and can be found in the guts of animals from insects to humans. Interestingly\, Blastocystis is closely associated with gut health\, correlating with decreased inflammation and high bacterial diversity. However\, we understand very little about the biology of this common organism\, which in the past has even been viewed as a parasite. Using comparative and functional genomics approaches in combination with mechanistic experiments on defined anaerobic cultures I investigate the function of Blastocystis and other commensal gut protists in the microbiome. These approaches have identified key biological principles of Blastocystis and in the future will determine how these common commensal gut protists interact with bacterial gut microbiota and the human host to impact health.
URL:https://www.med.unc.edu/compmed/event/faculty-candidate-seminar-11/
LOCATION:Bioinformatics Building\, Room 1131\, 130 Mason Farm Rd\, Chapel Hill\, NC\, 27514\, United States
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/Abigail-Lind-Headshot-scaled.jpeg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230113T100000
DTEND;TZID=America/New_York:20230113T110000
DTSTAMP:20260617T161632
CREATED:20230102T180718Z
LAST-MODIFIED:20230102T180848Z
UID:10000350-1673604000-1673607600@www.med.unc.edu
SUMMARY:No Meeting - Research in Progress
DESCRIPTION:In honor of Martin Luther King Jr. Day on Monday\, no meeting today.
URL:https://www.med.unc.edu/compmed/event/no-meeting-research-in-progress/
LOCATION:NC
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230117T160000
DTEND;TZID=America/New_York:20230117T170000
DTSTAMP:20260617T161632
CREATED:20220921T201121Z
LAST-MODIFIED:20230110T142312Z
UID:10000336-1673971200-1673974800@www.med.unc.edu
SUMMARY:Faculty Candidate Seminar
DESCRIPTION:Presenter: Christopher Park \nSimons Foundation\, Flatiron Institute\, New York \nCenter for Computational Biology \nTalk Title: The impact of RNA-binding protein dysregulation on psychiatric disorder risk \n  \nChristopher Park is a Flatiron Research Scientist at the Flatiron Institute\, a research division of the Simons Foundation. Christopher’s background is at the intersection of computational biology\, human genetics and RNA neurobiology\, focusing on elucidating the pathogenic mechanisms that connect genetic risk to psychiatric disorders. Christopher also holds a research interest in health conditions that intersect with the endocrine system. \nPrior to joining the Simons Foundation\, Christopher was a postdoctoral researcher in the laboratory of Dr. Robert Darnell at Rockefeller University and the New York Genome Center. He completed his Ph.D. training at Princeton University with Dr. Olga Troyanskaya. In addition to his Ph.D.\, Christopher holds a B.S. in Biochemistry and Computer Science from the University of Washington\, Seattle\, where he also worked with Dr. William Stafford Noble tackling problems related to proteomics.
URL:https://www.med.unc.edu/compmed/event/compmed-seminar-8/
LOCATION:NC
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2022/09/Christopher_Park-scaled.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230119T140000
DTEND;TZID=America/New_York:20230119T150000
DTSTAMP:20260617T161632
CREATED:20230102T194740Z
LAST-MODIFIED:20230102T194856Z
UID:10000353-1674136800-1674140400@www.med.unc.edu
SUMMARY:Faculty Candidate Seminar
DESCRIPTION:Presenter: Peng He\, PhD \nEuropean Bioinformatics Institute \nWellcome Sanger Institute \nTalk Title: Deciphering human organogenesis principles with single-cell and spatial technologies \n  \nDr. Peng He had his Bachelor’s in Statistics and Biochemistry at the University of Hong Kong\, after which he earned his PhD in genetics at California Institute of Technology. He now holds a joint postdoctoral research position between European Bioinformatics Institute (EMBL-EBI) and Wellcome Trust Sanger Institute
URL:https://www.med.unc.edu/compmed/event/faculty-candidate-seminar-12/
LOCATION:Bioinformatics Building\, Room 1131\, 130 Mason Farm Rd\, Chapel Hill\, NC\, 27514\, United States
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/HeP17Copy.jpeg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230120T100000
DTEND;TZID=America/New_York:20230120T110000
DTSTAMP:20260617T161632
CREATED:20230110T145019Z
LAST-MODIFIED:20230110T145019Z
UID:10000356-1674208800-1674212400@www.med.unc.edu
SUMMARY:CompMed Research in Progress
DESCRIPTION:Presenter: Xiaoqi Li (Yun Li Lab) \nTalk Title: “VAE-PRS: A deep learning based approach to compute polygenic risk score”
URL:https://www.med.unc.edu/compmed/event/compmed-research-in-progress-34/
LOCATION:Mary Ellen Jones 3112\, 116 Manning Drive\, Chapel Hill\, NC\, 27514
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/Xiaoqi.jpeg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230124T160000
DTEND;TZID=America/New_York:20230124T170000
DTSTAMP:20260617T161632
CREATED:20230110T143338Z
LAST-MODIFIED:20230110T144240Z
UID:10000354-1674576000-1674579600@www.med.unc.edu
SUMMARY:Faculty Candidate Seminar
DESCRIPTION:Presenter Christian Cuba-Samaniego\, PhD \nUniversity of California Los Angeles \nTalk Title: Adapting feedback control and pattern recognition paradigms for biotechnological applications \nEngineering synthetic networks with desired behavior for robust adaptation or complex decision-making is challenging. Current approaches rely on different negative regulation techniques or logic-based operators\, which suffer from suboptimal performance. To address this limitation\, we introduce two design principles: (1) ultrasensitive input-output behavior and (2) tunable thresholds. Here\, we engineer ultrasensitive-based networks to both achieve adaptive behavior through feedback control and build synthetic programs for molecular pattern recognition by implementing neural computing networks in living cells.
URL:https://www.med.unc.edu/compmed/event/faculty-candidate-seminar-13/
LOCATION:Bioinformatics Building\, Room 1131\, 130 Mason Farm Rd\, Chapel Hill\, NC\, 27514\, United States
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/Christian-Cuba-Samaniego.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230126T140000
DTEND;TZID=America/New_York:20230126T150000
DTSTAMP:20260617T161632
CREATED:20230110T143907Z
LAST-MODIFIED:20230110T143907Z
UID:10000355-1674741600-1674745200@www.med.unc.edu
SUMMARY:Faculty Candidate Seminar
DESCRIPTION:Presenter: Irene Kaplow\, PhD \nCarnegie Mellon University \nTalk Title: Relating enhancer genetic variation across mammals to complex phenotypes using machine learning \nLecture abstract: Advances in the genome sequencing have provided a comprehensive view of cross-species conservation across small segments of nucleotides.  These conservation measures have proven invaluable for associating phenotypic variation\, both within and across species\, to variation in genotype at protein-coding genes or highly conserved enhancers.  However\, these approaches cannot be applied to the vast majority of enhancers\, where the conservation levels of individual nucleotides are often low even when enhancer function is conserved and where activity is tissue- or cell type-specific.  To overcome these limitations\, we developed the Tissue-Aware Conservation Inference Toolkit (TACIT)\, in which convolutional neural network models learn the regulatory code connecting genome sequence to open chromatin in a tissue of interest\, allowing us to accurately predict cases where differences in genotype are associated with differences in open chromatin in that tissue at candidate enhancer regions.  We established a new set of evaluation criteria for machine learning models developed for this task and used these criteria to compare our models to models trained using different negative sets and to conservation scores.  We then developed a framework for connecting these predictions to phenotypes in a way that accounts for the phylogenetic tree.  When applying our framework to motor cortex\, we identified dozens of new candidate enhancers associated with the evolution of brain size and vocal learning. \nBio.: Irene Kaplow received her B.S. in Mathematics with a minor in Biology from the Massachusetts Institute of Technology in 2010. There\, she began her career as a computational biologist while doing research with Bonnie Berger. She then went to graduate school at Stanford University\, where she received her Ph.D. in Computer Science in 2017. At Stanford\, she worked in the Hunter Fraser and Anshul Kundaje’s labs to develop methods to analyze novel high-throughput sequencing datasets to better understand the roles of DNA methylation and Cys2-His2 zinc finger transcription factor binding in gene expression regulation. Irene is now a Lane Postdoctoral Fellow in Andreas Pfenning’s lab in the Computational Biology Department at Carnegie Mellon University\, where she is developing methods to identify enhancers involved in the evolution of neurological characteristics that have evolved through gene expression.
URL:https://www.med.unc.edu/compmed/event/faculty-candidate-seminar-14/
LOCATION:Bioinformatics Building\, Room 1131\, 130 Mason Farm Rd\, Chapel Hill\, NC\, 27514\, United States
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/compmed/wp-content/uploads/sites/852/2023/01/95Cropped.jpg
ORGANIZER;CN="Victoria Doyle":MAILTO:vdoyle@email.unc.edu
END:VEVENT
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