{"id":4615,"date":"2023-07-07T14:02:50","date_gmt":"2023-07-07T18:02:50","guid":{"rendered":"https:\/\/www.med.unc.edu\/compmed\/?p=4615"},"modified":"2023-07-07T14:32:01","modified_gmt":"2023-07-07T18:32:01","slug":"elizabeth-brunk","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/","title":{"rendered":"Featured Faculty: Elizabeth Brunk, PhD"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-4604\" src=\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg\" alt=\"Elizabeth Clair Brunk\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg 300w, https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-150x150.jpg 150w, https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk.jpg 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>A grand challenge in the genome sciences is identifying functionally relevant variants and interpreting their biological impacts on cellular systems. A growing body of work in the biomedical sciences generates and analyzes omics data; our work contributes to these efforts by focusing on the integration of different omics data types to bring mechanistic insights to the multi-scale nature of cellular processes influenced by genetic and molecular variation. My lab develops methods that accelerate the clarity and utility of omics data in biomedical science to link genetic and molecular variation to phenotype in cellular systems. The models we develop shine light on which genomic variants are most relevant to cell functioning and how they impact cellular processes like transcription, translation, and drug response.\u00a0\u00a0Molecular variants we study range from single nucleotide polymorphisms to focal oncogene amplifications. We integrate a wide array of experimental techniques, including cytogenetics, fluorescence microscopy, long-read sequencing, and single-cell transcriptomics, with computational methodologies, such as machine learning, data reduction and clustering, computational biology, and bioinformatics. Our overarching goal is to identify functionally relevant variants to advance precision medicine and targeted therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A grand challenge in the genome sciences is identifying functionally relevant variants and interpreting their biological impacts on cellular systems. A growing body of work in the biomedical sciences generates and analyzes omics data; our work contributes to these efforts by focusing on the integration of different omics data types to bring mechanistic insights to &hellip; <a href=\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\" aria-label=\"Read more about Featured Faculty: Elizabeth Brunk, PhD\">Read more<\/a><\/p>\n","protected":false},"author":89430,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[10],"tags":[],"class_list":["post-4615","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Featured Faculty: Elizabeth Brunk, PhD | Computational Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Featured Faculty: Elizabeth Brunk, PhD | Computational Medicine\" \/>\n<meta property=\"og:description\" content=\"A grand challenge in the genome sciences is identifying functionally relevant variants and interpreting their biological impacts on cellular systems. A growing body of work in the biomedical sciences generates and analyzes omics data; our work contributes to these efforts by focusing on the integration of different omics data types to bring mechanistic insights to &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\" \/>\n<meta property=\"og:site_name\" content=\"Computational Medicine\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-07T18:02:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-07T18:32:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg\" \/>\n<meta name=\"author\" content=\"vdoyle\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"vdoyle\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\"},\"author\":{\"name\":\"vdoyle\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/person\/2b90baa9d7d2f3c8f713c58b019c7c1a\"},\"headline\":\"Featured Faculty: Elizabeth Brunk, PhD\",\"datePublished\":\"2023-07-07T18:02:50+00:00\",\"dateModified\":\"2023-07-07T18:32:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\"},\"wordCount\":188,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\",\"url\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\",\"name\":\"Featured Faculty: Elizabeth Brunk, PhD | Computational Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg\",\"datePublished\":\"2023-07-07T18:02:50+00:00\",\"dateModified\":\"2023-07-07T18:32:01+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk.jpg\",\"width\":400,\"height\":400,\"caption\":\"Elizabeth Clair Brunk\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/compmed\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Featured Faculty: Elizabeth Brunk, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/compmed\/\",\"name\":\"Computational Medicine\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/compmed\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#organization\",\"name\":\"UNC Computational Medicine Program\",\"url\":\"https:\/\/www.med.unc.edu\/compmed\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2018\/02\/COMPMEDlogoSMALLSWITCH.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2018\/02\/COMPMEDlogoSMALLSWITCH.png\",\"width\":300,\"height\":165,\"caption\":\"UNC Computational Medicine Program\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/person\/2b90baa9d7d2f3c8f713c58b019c7c1a\",\"name\":\"vdoyle\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/a2acd2ee7f4994d32f91fbdcced8a38277a63002af65efdc1031c5652d0769ec?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/a2acd2ee7f4994d32f91fbdcced8a38277a63002af65efdc1031c5652d0769ec?s=96&d=mm&r=g\",\"caption\":\"vdoyle\"},\"url\":\"https:\/\/www.med.unc.edu\/compmed\/author\/vdoyle\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Featured Faculty: Elizabeth Brunk, PhD | Computational Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/","og_locale":"en_US","og_type":"article","og_title":"Featured Faculty: Elizabeth Brunk, PhD | Computational Medicine","og_description":"A grand challenge in the genome sciences is identifying functionally relevant variants and interpreting their biological impacts on cellular systems. A growing body of work in the biomedical sciences generates and analyzes omics data; our work contributes to these efforts by focusing on the integration of different omics data types to bring mechanistic insights to &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/","og_site_name":"Computational Medicine","article_published_time":"2023-07-07T18:02:50+00:00","article_modified_time":"2023-07-07T18:32:01+00:00","og_image":[{"url":"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg","type":"","width":"","height":""}],"author":"vdoyle","twitter_card":"summary_large_image","twitter_misc":{"Written by":"vdoyle","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/"},"author":{"name":"vdoyle","@id":"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/person\/2b90baa9d7d2f3c8f713c58b019c7c1a"},"headline":"Featured Faculty: Elizabeth Brunk, PhD","datePublished":"2023-07-07T18:02:50+00:00","dateModified":"2023-07-07T18:32:01+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/"},"wordCount":188,"publisher":{"@id":"https:\/\/www.med.unc.edu\/compmed\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/","url":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/","name":"Featured Faculty: Elizabeth Brunk, PhD | Computational Medicine","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/compmed\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk-300x300.jpg","datePublished":"2023-07-07T18:02:50+00:00","dateModified":"2023-07-07T18:32:01+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#primaryimage","url":"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk.jpg","contentUrl":"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2023\/05\/Elizabeth-Clair-Brunk.jpg","width":400,"height":400,"caption":"Elizabeth Clair Brunk"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/compmed\/2023\/07\/elizabeth-brunk\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/compmed\/"},{"@type":"ListItem","position":2,"name":"Featured Faculty: Elizabeth Brunk, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/compmed\/#website","url":"https:\/\/www.med.unc.edu\/compmed\/","name":"Computational Medicine","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/compmed\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/compmed\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/compmed\/#organization","name":"UNC Computational Medicine Program","url":"https:\/\/www.med.unc.edu\/compmed\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2018\/02\/COMPMEDlogoSMALLSWITCH.png","contentUrl":"https:\/\/www.med.unc.edu\/compmed\/wp-content\/uploads\/sites\/852\/2018\/02\/COMPMEDlogoSMALLSWITCH.png","width":300,"height":165,"caption":"UNC Computational Medicine Program"},"image":{"@id":"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/person\/2b90baa9d7d2f3c8f713c58b019c7c1a","name":"vdoyle","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/compmed\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a2acd2ee7f4994d32f91fbdcced8a38277a63002af65efdc1031c5652d0769ec?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a2acd2ee7f4994d32f91fbdcced8a38277a63002af65efdc1031c5652d0769ec?s=96&d=mm&r=g","caption":"vdoyle"},"url":"https:\/\/www.med.unc.edu\/compmed\/author\/vdoyle\/"}]}},"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":false,"category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/compmed\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/posts\/4615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/users\/89430"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/comments?post=4615"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/posts\/4615\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/media?parent=4615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/categories?post=4615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/compmed\/wp-json\/wp\/v2\/tags?post=4615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}