{"id":3648,"date":"2020-11-10T14:03:19","date_gmt":"2020-11-10T19:03:19","guid":{"rendered":"https:\/\/www.med.unc.edu\/compmed\/?post_type=tribe_events&#038;p=3648"},"modified":"2021-02-05T11:13:24","modified_gmt":"2021-02-05T16:13:24","slug":"computational-medicine-seminar-10","status":"publish","type":"tribe_events","link":"https:\/\/www.med.unc.edu\/compmed\/event\/computational-medicine-seminar-10\/","title":{"rendered":"Computational Medicine Seminar"},"content":{"rendered":"<p>Presenter: Kevin Janes, PhD<\/p>\n<p>Talk Title: &#8220;<strong>Complete kinetic modeling of an RNA pathogen&#8221;<\/strong><\/p>\n<p>Complete kinetic models are pervasive in chemistry but lacking in biological systems.\u00a0We encoded the complete kinetics of infection for coxsackievirus B3 (CVB3), a compact and fast-acting RNA virus.\u00a0The kinetics are built from detailed modules for viral binding\u2013delivery, translation\u2013replication, and encapsidation.\u00a0Specific module activities are dampened by the type I interferon response to viral double-stranded RNAs (dsRNAs), which is itself disrupted by viral proteinases.\u00a0The validated kinetics uncovered that cleavability of the dsRNA transducer mitochondrial antiviral signaling protein (MAVS) becomes a stronger determinant of viral outcomes when cells receive supplemental interferon after infection.\u00a0Cleavability is naturally altered in humans by a common MAVS polymorphism, which removes a proteinase-targeted site but paradoxically elevates CVB3 infectivity.\u00a0These observations are reconciled with a simple nonlinear model of MAVS regulation.\u00a0Modeling complete kinetics is an attainable goal for small, rapidly infecting viruses and perhaps viral pathogens more broadly.<\/p>\n<div class=\"entry-content-asset\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"lLHNBC4rfe\"><p><a href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/kaj5f\/\">Janes, Kevin A.<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Janes, Kevin A.&#8221; &#8212; Research Faculty Directory\" src=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/kaj5f\/embed\/#?secret=lLHNBC4rfe\" data-secret=\"lLHNBC4rfe\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Presenter: Kevin Janes, PhD Talk Title: &#8220;Complete kinetic modeling of an RNA pathogen&#8221; Complete kinetic models are pervasive in chemistry but lacking in biological systems.\u00a0We encoded the complete kinetics of infection for coxsackievirus B3 (CVB3), a compact and fast-acting RNA virus.\u00a0The kinetics are built from detailed modules for viral binding\u2013delivery, translation\u2013replication, and encapsidation.\u00a0Specific module activities &hellip; <a href=\"https:\/\/www.med.unc.edu\/compmed\/event\/computational-medicine-seminar-10\/\" aria-label=\"Read more about Computational Medicine Seminar\">Read more<\/a><\/p>\n","protected":false},"author":89430,"featured_media":3753,"template":"","meta":{"_acf_changed":false,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"tribe_events_cat":[9],"class_list":["post-3648","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-seminar","cat_seminar","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Computational 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